CD45 / PTPRC Monoclonal Antibody (CC1) | Invitrogen MA1-80051 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon

product type :

antibody

product name :

CD45 / PTPRC Monoclonal Antibody (CC1)

catalog :

MA1-80051

quantity :

2 ml

price :

US 349

clonality :

monoclonal

host :

mouse

reactivity :

cow

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

product information

Product Type :

MA1-80051

Product Name :

CD45 / PTPRC Monoclonal Antibody (CC1)

Catalog # :

MA1-80051

Quantity :

2 ml

Price :

US 349

Clonality :

Monoclonal

Purity :

Unpurified

Host :

Mouse

Reactivity :

Bovine

Applications :

Flow Cytometry, Immunohistochemistry (Frozen) and Immunoprecipitation

Species :

Clone :

CC1

Gene Identification :

Entrez: 407152

Isotype :

IgG1

Storage :

4°C or -20°C if preferred

Description :

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.

Immunogen :

Proprietary Immunogen.

Format :

Liquid; tissue culture supernatant, 0.09 % sodium azide

Applications w/Dilutions :

IHC (F) Neat - 1/5, IP Assay Dependent, FACS Neat - 1/10

Aliases :

B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, CD45 antigen, T200 glycoprotein, T200 leukocyte common antigen, protein tyrosine phosphatase, receptor type, c polypeptide, receptor-type tyrosine-protein phosphatase C

PubMed References :

15294914