product summary
request information :
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
ERalpha (D-12) Antibody
catalog :
sc-8005
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
immunohistochemistry - paraffin section, western blot, ELISA, immunoprecipitation, immunohistochemistry, immunocytochemistry
publications citing this reagent :
total: 45
  1. Kobelt L, Klammt J, Tefs K, Schuster V. Estrogen modulates plasminogen promoter activity. Biochem Biophys Res Commun. 2013;438:110-5 pubmed publisher
  2. Kharbanda A, Rajabi H, Jin C, Raina D, Kufe D. Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer. Mol Cancer Res. 2013;11:714-23 pubmed publisher
  3. Wardell S, Nelson E, Chao C, McDonnell D. Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. Clin Cancer Res. 2013;19:2420-31 pubmed publisher
  4. Inaba T, Kobayashi T, Tsutsui T, Ogawa M, Uchida M, Tsutsui T. Expression status of mRNA for sex hormone receptors in human dental pulp cells and the response to sex hormones in the cells. Arch Oral Biol. 2013;58:943-50 pubmed publisher
  5. Simmons M, Serra R, Hermance N, Kelliher M. NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere forming activity in vitro. Breast Cancer Res. 2012;14:R126 pubmed
  6. Marconett C, Singhal A, Sundar S, Firestone G. Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells. Mol Cell Endocrinol. 2012;363:74-84 pubmed publisher
  7. Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed publisher
  8. Liu W, Swetzig W, Medisetty R, Das G. Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells. PLoS ONE. 2011;6:e29466 pubmed publisher
  9. Piastowska-Ciesielska A, Płuciennik E, Wójcik-Krowiranda K, Bienkiewicz A, Bednarek A, Ochedalski T. Analysis of the expression of angiotensin II type 1 receptor and VEGF in endometrial adenocarcinoma with different clinicopathological characteristics. Tumour Biol. 2012;33:767-74 pubmed publisher
  10. Papanikolaou V, Athanassiou E, Dubos S, Dimou I, Papathanasiou I, Kitsiou-Tzeli S, et al. hTERT regulation by NF-κB and c-myc in irradiated HER2-positive breast cancer cells. Int J Radiat Biol. 2011;87:609-21 pubmed publisher
product information
product name :
ERalpha (D-12) Antibody
gene name :
ESR1
size :
200 µg/ml
price :
279 USD
catalog number :
sc-8005
type :
Monoclonal
host :
mouse monoclonal
antigen :
ERalpha
reactive species :
human
applications :
WB, IP, PAR, ELISA
epitope :
N-terminal (h)
delivery :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
publications citing this reagent :
  1. Wardell S, Marks J, McDonnell D. The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. Biochem Pharmacol. 2011;82:122-30 pubmed publisher
  2. Alimirah F, Peng X, Murillo G, Mehta R. Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells. PLoS ONE. 2011;6:e16024 pubmed publisher
  3. Sharma G, Mirza S, Parshad R, Srivastava A, Gupta S, Pandya P, et al. Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients. Life Sci. 2010;87:83-91 pubmed publisher
  4. Lee S, Lee S, Ha N, Park B. Estrogen prevents senescence through induction of WRN, Werner syndrome protein. Horm Res Paediatr. 2010;74:33-40 pubmed publisher
  5. Peidis P, Giannakouros T, Burow M, Williams R, Scott R. Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-repressor. BMC Syst Biol. 2010;4:14 pubmed publisher
  6. Marconett C, Sundar S, Poindexter K, Stueve T, Bjeldanes L, Firestone G. Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop. Mol Biol Cell. 2010;21:1166-77 pubmed publisher
  7. Mirza S, Sharma G, Parshad R, Srivastava A, Gupta S, Ralhan R. Clinical significance of Stratifin, ERalpha and PR promoter methylation in tumor and serum DNA in Indian breast cancer patients. Clin Biochem. 2010;43:380-6 pubmed publisher
  8. Prasad C, Rath G, Mathur S, Bhatnagar D, Ralhan R. Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines. Chem Biol Interact. 2010;183:455-61 pubmed publisher
  9. Sharma G, Mirza S, Yang Y, Parshad R, Hazrah P, Datta Gupta S, et al. Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients. Cell Oncol. 2009;31:487-500 pubmed publisher
  10. Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, et al. Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell. 2009;36:340-7 pubmed publisher
  11. Taslim C, Wu J, Yan P, Singer G, Parvin J, Huang T, et al. Comparative study on ChIP-seq data: normalization and binding pattern characterization. Bioinformatics. 2009;25:2334-40 pubmed publisher
  12. Wong J, Weickert C. Transcriptional interaction of an estrogen receptor splice variant and ErbB4 suggests convergence in gene susceptibility pathways in schizophrenia. J Biol Chem. 2009;284:18824-32 pubmed publisher
  13. Polotsky A, Zhu L, Santoro N, Pollard J. Lithium chloride treatment induces epithelial cell proliferation in xenografted human endometrium. Hum Reprod. 2009;24:1960-7 pubmed publisher
  14. Schultz-Norton J, Ziegler Y, Likhite V, Yates J, Nardulli A. Isolation of novel coregulatory protein networks associated with DNA-bound estrogen receptor alpha. BMC Mol Biol. 2008;9:97 pubmed publisher
  15. Feng W, Liu Y, Wu J, Nephew K, Huang T, Li L. A Poisson mixture model to identify changes in RNA polymerase II binding quantity using high-throughput sequencing technology. BMC Genomics. 2008;9:S23 pubmed publisher
  16. Thasni K, Rakesh S, Rojini G, Ratheeshkumar T, Srinivas G, Priya S. Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents. Ann Oncol. 2008;19:696-705 pubmed publisher
  17. Curtis C, Likhite V, McLeod I, Yates J, Nardulli A. Interaction of the tumor metastasis suppressor nonmetastatic protein 23 homologue H1 and estrogen receptor alpha alters estrogen-responsive gene expression. Cancer Res. 2007;67:10600-7 pubmed
  18. Dhasarathy A, Kajita M, Wade P. The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha. Mol Endocrinol. 2007;21:2907-18 pubmed
  19. Mirza S, Sharma G, Prasad C, Parshad R, Srivastava A, Gupta S, et al. Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients. Life Sci. 2007;81:280-7 pubmed
  20. Schultz-Norton J, Walt K, Ziegler Y, McLeod I, Yates J, Raetzman L, et al. The deoxyribonucleic acid repair protein flap endonuclease-1 modulates estrogen-responsive gene expression. Mol Endocrinol. 2007;21:1569-80 pubmed
  21. Niklaus A, Aubuchon M, Zapantis G, Li P, Qian H, Isaac B, et al. Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition women. Hum Reprod. 2007;22:1778-88 pubmed
  22. Schmidt A, Nanney L, Boyd A, King L, Ellis D. Oestrogen receptor-beta expression in melanocytic lesions. Exp Dermatol. 2006;15:971-80 pubmed
  23. Scoles D, Pavelka J, Cass I, Tran H, Baldwin R, Armstrong K, et al. Characterization of CSOC 882, a novel immortalized ovarian cancer cell line expressing EGFR, HER2, and activated AKT. Gynecol Oncol. 2007;104:120-8 pubmed
  24. Al-Dhaheri M, Rowan B. Application of phosphorylation site-specific antibodies to measure nuclear receptor signaling: characterization of novel phosphoantibodies for estrogen receptor alpha. Nucl Recept Signal. 2006;4:e007 pubmed
  25. Koduri S, Goldhar A, Vonderhaar B. Activation of vascular endothelial growth factor (VEGF) by the ER-alpha variant, ERDelta3. Breast Cancer Res Treat. 2006;95:37-43 pubmed
  26. Fog C, Christensen I, Lykkesfeldt A. Characterization of a human breast cancer cell line, MCF-7/RU58R-1, resistant to the pure antiestrogen RU 58,668. Breast Cancer Res Treat. 2005;91:133-44 pubmed
  27. Ji Q, Liu P, Elshimali Y, Stolz A. Frequent loss of estrogen and progesterone receptors in human prostatic tumors determined by quantitative real-time PCR. Mol Cell Endocrinol. 2005;229:103-10 pubmed
  28. Loven M, Davis R, Curtis C, Muster N, Yates J, Nardulli A. A novel estrogen receptor alpha-associated protein alters receptor-deoxyribonucleic acid interactions and represses receptor-mediated transcription. Mol Endocrinol. 2004;18:2649-59 pubmed
  29. Carling T, Kim K, Yang X, Gu J, Zhang X, Huang S. A histone methyltransferase is required for maximal response to female sex hormones. Mol Cell Biol. 2004;24:7032-42 pubmed
  30. Christensen G, Jepsen J, Fog C, Christensen I, Lykkesfeldt A. Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment. Breast Cancer Res Treat. 2004;85:53-63 pubmed
  31. Likhite V, Cass E, Anderson S, Yates J, Nardulli A. Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair. J Biol Chem. 2004;279:16875-82 pubmed
  32. Petz L, Ziegler Y, Schultz J, Nardulli A. Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site. Mol Endocrinol. 2004;18:521-32 pubmed
  33. Petz L, Ziegler Y, Loven M, Nardulli A. Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells. Endocrinology. 2002;143:4583-91 pubmed
  34. Pinkston J, Marapane S, Jordan G, Clair B. Characterization of low molecular weight alkoxylated polymers using long column SFC/MS and an image analysis based quantitation approach. J Am Soc Mass Spectrom. 2002;13:1195-208 pubmed
  35. Lee E, Jakacka M, Duan W, Chien P, Martinson F, Gehm B, et al. Adenovirus-directed expression of dominant negative estrogen receptor induces apoptosis in breast cancer cells and regression of tumors in nude mice. Mol Med. 2001;7:773-82 pubmed
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
www.scbt.com
1.800.457.3801
headquarters: USA