product summary
request information :
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
ERalpha (D-12) Antibody
catalog :
sc-8005
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 41
Published Application/Species/DilutionReference
  • western blot; mouse; 1:300
Bacallao K, Plaza-Parrochia F, Cerda A, Gabler F, Romero C, Vantman D, et al. Levels of Regulatory Proteins Associated With Cell Proliferation in Endometria From Untreated Patients Having Polycystic Ovarian Syndrome With and Without Endometrial Hyperplasia. Reprod Sci. 2016;23:211-8 pubmed publisher
  • western blot; human
Papanikolaou V, Stefanou N, Dubos S, Papathanasiou I, Palianopoulou M, Valiakou V, et al. Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes. Cell Oncol (Dordr). 2015;38:155-64 pubmed publisher
  • western blot; human
Teng Y, Radde B, Litchfield L, Ivanova M, Prough R, Clark B, et al. Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015;290:15799-811 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:75
Bouchekioua-Bouzaghou K, Poulard C, Rambaud J, Lavergne E, Hussein N, Billaud M, et al. LKB1 when associated with methylatedERα is a marker of bad prognosis in breast cancer. Int J Cancer. 2014;135:1307-18 pubmed publisher
  • immunoprecipitation; mouse; fig 1
Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, et al. Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell. 2009;36:340-7 pubmed publisher
Wardell S, Nelson E, Chao C, McDonnell D. Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. Clin Cancer Res. 2013;19:2420-31 pubmed publisher
Kharbanda A, Rajabi H, Jin C, Raina D, Kufe D. Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer. Mol Cancer Res. 2013;11:714-23 pubmed publisher
Inaba T, Kobayashi T, Tsutsui T, Ogawa M, Uchida M, Tsutsui T. Expression status of mRNA for sex hormone receptors in human dental pulp cells and the response to sex hormones in the cells. Arch Oral Biol. 2013;58:943-50 pubmed publisher
Kobelt L, Klammt J, Tefs K, Schuster V. Estrogen modulates plasminogen promoter activity. Biochem Biophys Res Commun. 2013;438:110-5 pubmed publisher
Marconett C, Sundar S, Poindexter K, Stueve T, Bjeldanes L, Firestone G. Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop. Mol Biol Cell. 2010;21:1166-77 pubmed publisher
Piastowska-Ciesielska A, Płuciennik E, Wójcik-Krowiranda K, Bienkiewicz A, Bednarek A, Ochedalski T. Analysis of the expression of angiotensin II type 1 receptor and VEGF in endometrial adenocarcinoma with different clinicopathological characteristics. Tumour Biol. 2012;33:767-74 pubmed publisher
Taslim C, Wu J, Yan P, Singer G, Parvin J, Huang T, et al. Comparative study on ChIP-seq data: normalization and binding pattern characterization. Bioinformatics. 2009;25:2334-40 pubmed publisher
Marconett C, Singhal A, Sundar S, Firestone G. Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells. Mol Cell Endocrinol. 2012;363:74-84 pubmed publisher
Liu W, Swetzig W, Medisetty R, Das G. Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells. PLoS ONE. 2011;6:e29466 pubmed publisher
Papanikolaou V, Athanassiou E, Dubos S, Dimou I, Papathanasiou I, Kitsiou-Tzeli S, et al. hTERT regulation by NF-κB and c-myc in irradiated HER2-positive breast cancer cells. Int J Radiat Biol. 2011;87:609-21 pubmed publisher
Peidis P, Giannakouros T, Burow M, Williams R, Scott R. Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-repressor. BMC Syst Biol. 2010;4:14 pubmed publisher
Schultz-Norton J, Ziegler Y, Likhite V, Yates J, Nardulli A. Isolation of novel coregulatory protein networks associated with DNA-bound estrogen receptor alpha. BMC Mol Biol. 2008;9:97 pubmed publisher
Scoles D, Pavelka J, Cass I, Tran H, Baldwin R, Armstrong K, et al. Characterization of CSOC 882, a novel immortalized ovarian cancer cell line expressing EGFR, HER2, and activated AKT. Gynecol Oncol. 2007;104:120-8 pubmed
Thasni K, Rakesh S, Rojini G, Ratheeshkumar T, Srinivas G, Priya S. Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents. Ann Oncol. 2008;19:696-705 pubmed publisher
Niklaus A, Aubuchon M, Zapantis G, Li P, Qian H, Isaac B, et al. Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition women. Hum Reprod. 2007;22:1778-88 pubmed
Schultz-Norton J, Walt K, Ziegler Y, McLeod I, Yates J, Raetzman L, et al. The deoxyribonucleic acid repair protein flap endonuclease-1 modulates estrogen-responsive gene expression. Mol Endocrinol. 2007;21:1569-80 pubmed
Mirza S, Sharma G, Parshad R, Srivastava A, Gupta S, Ralhan R. Clinical significance of Stratifin, ERalpha and PR promoter methylation in tumor and serum DNA in Indian breast cancer patients. Clin Biochem. 2010;43:380-6 pubmed publisher
Sharma G, Mirza S, Yang Y, Parshad R, Hazrah P, Datta Gupta S, et al. Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients. Cell Oncol. 2009;31:487-500 pubmed publisher
Wong J, Weickert C. Transcriptional interaction of an estrogen receptor splice variant and ErbB4 suggests convergence in gene susceptibility pathways in schizophrenia. J Biol Chem. 2009;284:18824-32 pubmed publisher
Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed publisher
Alimirah F, Peng X, Murillo G, Mehta R. Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells. PLoS ONE. 2011;6:e16024 pubmed publisher
Simmons M, Serra R, Hermance N, Kelliher M. NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere forming activity in vitro. Breast Cancer Res. 2012;14:R126 pubmed
Curtis C, Likhite V, McLeod I, Yates J, Nardulli A. Interaction of the tumor metastasis suppressor nonmetastatic protein 23 homologue H1 and estrogen receptor alpha alters estrogen-responsive gene expression. Cancer Res. 2007;67:10600-7 pubmed
Koduri S, Goldhar A, Vonderhaar B. Activation of vascular endothelial growth factor (VEGF) by the ER-alpha variant, ERDelta3. Breast Cancer Res Treat. 2006;95:37-43 pubmed
Schmidt A, Nanney L, Boyd A, King L, Ellis D. Oestrogen receptor-beta expression in melanocytic lesions. Exp Dermatol. 2006;15:971-80 pubmed
Lee S, Lee S, Ha N, Park B. Estrogen prevents senescence through induction of WRN, Werner syndrome protein. Horm Res Paediatr. 2010;74:33-40 pubmed publisher
Mirza S, Sharma G, Prasad C, Parshad R, Srivastava A, Gupta S, et al. Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients. Life Sci. 2007;81:280-7 pubmed
Fog C, Christensen I, Lykkesfeldt A. Characterization of a human breast cancer cell line, MCF-7/RU58R-1, resistant to the pure antiestrogen RU 58,668. Breast Cancer Res Treat. 2005;91:133-44 pubmed
Feng W, Liu Y, Wu J, Nephew K, Huang T, Li L. A Poisson mixture model to identify changes in RNA polymerase II binding quantity using high-throughput sequencing technology. BMC Genomics. 2008;9:S23 pubmed publisher
Al-Dhaheri M, Rowan B. Application of phosphorylation site-specific antibodies to measure nuclear receptor signaling: characterization of novel phosphoantibodies for estrogen receptor alpha. Nucl Recept Signal. 2006;4:e007 pubmed
Dhasarathy A, Kajita M, Wade P. The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha. Mol Endocrinol. 2007;21:2907-18 pubmed
Wardell S, Marks J, McDonnell D. The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. Biochem Pharmacol. 2011;82:122-30 pubmed publisher
Ji Q, Liu P, Elshimali Y, Stolz A. Frequent loss of estrogen and progesterone receptors in human prostatic tumors determined by quantitative real-time PCR. Mol Cell Endocrinol. 2005;229:103-10 pubmed
Sharma G, Mirza S, Parshad R, Srivastava A, Gupta S, Pandya P, et al. Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients. Life Sci. 2010;87:83-91 pubmed publisher
Polotsky A, Zhu L, Santoro N, Pollard J. Lithium chloride treatment induces epithelial cell proliferation in xenografted human endometrium. Hum Reprod. 2009;24:1960-7 pubmed publisher
Prasad C, Rath G, Mathur S, Bhatnagar D, Ralhan R. Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines. Chem Biol Interact. 2010;183:455-61 pubmed publisher
product information
product name :
ERalpha (D-12) Antibody
gene name :
ESR1
size :
200 µg/ml
price :
279 USD
catalog number :
sc-8005
type :
Monoclonal
host :
mouse monoclonal
antigen :
ERalpha
reactive species  :
human
applications :
WB, IP, PAR, ELISA
epitope :
N-terminal (h)
delivery :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
www.scbt.com
1.800.457.3801
headquarters: USA