product summary
request information :
company name :
Santa Cruz Biotechnology
product type :
product name :
ERalpha (D-12) Antibody
catalog :
quantity :
200 µg/ml
price :
279 USD
clonality :
host :
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
publications citing this reagent :
total: 41
  1. mouse (western blot(1:300))
    Bacallao K, Plaza-Parrochia F, Cerda A, Gabler F, Romero C, Vantman D, et al. Levels of Regulatory Proteins Associated With Cell Proliferation in Endometria From Untreated Patients Having Polycystic Ovarian Syndrome With and Without Endometrial Hyperplasia. Reprod Sci. 2015;: pubmed
  2. human (western blot)
    Teng Y, Radde B, Litchfield L, Ivanova M, Prough R, Clark B, et al. Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015;290:15799-811 pubmed publisher
  3. human (western blot)
    Papanikolaou V, Stefanou N, Dubos S, Papathanasiou I, Palianopoulou M, Valiakou V, et al. Synergy of leptin/STAT3 with HER2 receptor induces tamoxifen resistance in breast cancer cells through regulation of apoptosis-related genes. Cell Oncol (Dordr). 2015;38:155-64 pubmed publisher
  4. human (immunohistochemistry - paraffin section(1:75))
    Bouchekioua-Bouzaghou K, Poulard C, Rambaud J, Lavergne E, Hussein N, Billaud M, et al. LKB1 when associated with methylatedERα is a marker of bad prognosis in breast cancer. Int J Cancer. 2014;135:1307-18 pubmed publisher
  5. Kobelt L, Klammt J, Tefs K, Schuster V. Estrogen modulates plasminogen promoter activity. Biochem Biophys Res Commun. 2013;438:110-5 pubmed publisher
  6. Kharbanda A, Rajabi H, Jin C, Raina D, Kufe D. Oncogenic MUC1-C promotes tamoxifen resistance in human breast cancer. Mol Cancer Res. 2013;11:714-23 pubmed publisher
  7. Wardell S, Nelson E, Chao C, McDonnell D. Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. Clin Cancer Res. 2013;19:2420-31 pubmed publisher
  8. Inaba T, Kobayashi T, Tsutsui T, Ogawa M, Uchida M, Tsutsui T. Expression status of mRNA for sex hormone receptors in human dental pulp cells and the response to sex hormones in the cells. Arch Oral Biol. 2013;58:943-50 pubmed publisher
  9. Simmons M, Serra R, Hermance N, Kelliher M. NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere forming activity in vitro. Breast Cancer Res. 2012;14:R126 pubmed
  10. Marconett C, Singhal A, Sundar S, Firestone G. Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells. Mol Cell Endocrinol. 2012;363:74-84 pubmed publisher
product information
product name :
ERalpha (D-12) Antibody
gene name :
size :
200 µg/ml
price :
279 USD
catalog number :
type :
host :
mouse monoclonal
antigen :
reactive species  :
applications :
epitope :
N-terminal (h)
delivery :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
publications citing this reagent :
  1. Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed publisher
  2. Liu W, Swetzig W, Medisetty R, Das G. Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells. PLoS ONE. 2011;6:e29466 pubmed publisher
  3. Piastowska-Ciesielska A, Płuciennik E, Wójcik-Krowiranda K, Bienkiewicz A, Bednarek A, Ochedalski T. Analysis of the expression of angiotensin II type 1 receptor and VEGF in endometrial adenocarcinoma with different clinicopathological characteristics. Tumour Biol. 2012;33:767-74 pubmed publisher
  4. Papanikolaou V, Athanassiou E, Dubos S, Dimou I, Papathanasiou I, Kitsiou-Tzeli S, et al. hTERT regulation by NF-κB and c-myc in irradiated HER2-positive breast cancer cells. Int J Radiat Biol. 2011;87:609-21 pubmed publisher
  5. Wardell S, Marks J, McDonnell D. The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacy. Biochem Pharmacol. 2011;82:122-30 pubmed publisher
  6. Alimirah F, Peng X, Murillo G, Mehta R. Functional significance of vitamin D receptor FokI polymorphism in human breast cancer cells. PLoS ONE. 2011;6:e16024 pubmed publisher
  7. Sharma G, Mirza S, Parshad R, Srivastava A, Gupta S, Pandya P, et al. Clinical significance of promoter hypermethylation of DNA repair genes in tumor and serum DNA in invasive ductal breast carcinoma patients. Life Sci. 2010;87:83-91 pubmed publisher
  8. Lee S, Lee S, Ha N, Park B. Estrogen prevents senescence through induction of WRN, Werner syndrome protein. Horm Res Paediatr. 2010;74:33-40 pubmed publisher
  9. Peidis P, Giannakouros T, Burow M, Williams R, Scott R. Systems genetics analyses predict a transcription role for P2P-R: molecular confirmation that P2P-R is a transcriptional co-repressor. BMC Syst Biol. 2010;4:14 pubmed publisher
  10. Marconett C, Sundar S, Poindexter K, Stueve T, Bjeldanes L, Firestone G. Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop. Mol Biol Cell. 2010;21:1166-77 pubmed publisher
  11. Mirza S, Sharma G, Parshad R, Srivastava A, Gupta S, Ralhan R. Clinical significance of Stratifin, ERalpha and PR promoter methylation in tumor and serum DNA in Indian breast cancer patients. Clin Biochem. 2010;43:380-6 pubmed publisher
  12. Prasad C, Rath G, Mathur S, Bhatnagar D, Ralhan R. Expression analysis of maspin in invasive ductal carcinoma of breast and modulation of its expression by curcumin in breast cancer cell lines. Chem Biol Interact. 2010;183:455-61 pubmed publisher
  13. Sharma G, Mirza S, Yang Y, Parshad R, Hazrah P, Datta Gupta S, et al. Prognostic relevance of promoter hypermethylation of multiple genes in breast cancer patients. Cell Oncol. 2009;31:487-500 pubmed publisher
  14. mouse (immunoprecipitation)
    Yamagata K, Fujiyama S, Ito S, Ueda T, Murata T, Naitou M, et al. Maturation of microRNA is hormonally regulated by a nuclear receptor. Mol Cell. 2009;36:340-7 pubmed publisher
  15. Taslim C, Wu J, Yan P, Singer G, Parvin J, Huang T, et al. Comparative study on ChIP-seq data: normalization and binding pattern characterization. Bioinformatics. 2009;25:2334-40 pubmed publisher
  16. Wong J, Weickert C. Transcriptional interaction of an estrogen receptor splice variant and ErbB4 suggests convergence in gene susceptibility pathways in schizophrenia. J Biol Chem. 2009;284:18824-32 pubmed publisher
  17. Polotsky A, Zhu L, Santoro N, Pollard J. Lithium chloride treatment induces epithelial cell proliferation in xenografted human endometrium. Hum Reprod. 2009;24:1960-7 pubmed publisher
  18. Schultz-Norton J, Ziegler Y, Likhite V, Yates J, Nardulli A. Isolation of novel coregulatory protein networks associated with DNA-bound estrogen receptor alpha. BMC Mol Biol. 2008;9:97 pubmed publisher
  19. Feng W, Liu Y, Wu J, Nephew K, Huang T, Li L. A Poisson mixture model to identify changes in RNA polymerase II binding quantity using high-throughput sequencing technology. BMC Genomics. 2008;9:S23 pubmed publisher
  20. Thasni K, Rakesh S, Rojini G, Ratheeshkumar T, Srinivas G, Priya S. Estrogen-dependent cell signaling and apoptosis in BRCA1-blocked BG1 ovarian cancer cells in response to plumbagin and other chemotherapeutic agents. Ann Oncol. 2008;19:696-705 pubmed publisher
  21. Curtis C, Likhite V, McLeod I, Yates J, Nardulli A. Interaction of the tumor metastasis suppressor nonmetastatic protein 23 homologue H1 and estrogen receptor alpha alters estrogen-responsive gene expression. Cancer Res. 2007;67:10600-7 pubmed
  22. Dhasarathy A, Kajita M, Wade P. The transcription factor snail mediates epithelial to mesenchymal transitions by repression of estrogen receptor-alpha. Mol Endocrinol. 2007;21:2907-18 pubmed
  23. Mirza S, Sharma G, Prasad C, Parshad R, Srivastava A, Gupta S, et al. Promoter hypermethylation of TMS1, BRCA1, ERalpha and PRB in serum and tumor DNA of invasive ductal breast carcinoma patients. Life Sci. 2007;81:280-7 pubmed
  24. Schultz-Norton J, Walt K, Ziegler Y, McLeod I, Yates J, Raetzman L, et al. The deoxyribonucleic acid repair protein flap endonuclease-1 modulates estrogen-responsive gene expression. Mol Endocrinol. 2007;21:1569-80 pubmed
  25. Niklaus A, Aubuchon M, Zapantis G, Li P, Qian H, Isaac B, et al. Assessment of the proliferative status of epithelial cell types in the endometrium of young and menopausal transition women. Hum Reprod. 2007;22:1778-88 pubmed
  26. Schmidt A, Nanney L, Boyd A, King L, Ellis D. Oestrogen receptor-beta expression in melanocytic lesions. Exp Dermatol. 2006;15:971-80 pubmed
  27. Scoles D, Pavelka J, Cass I, Tran H, Baldwin R, Armstrong K, et al. Characterization of CSOC 882, a novel immortalized ovarian cancer cell line expressing EGFR, HER2, and activated AKT. Gynecol Oncol. 2007;104:120-8 pubmed
  28. Al-Dhaheri M, Rowan B. Application of phosphorylation site-specific antibodies to measure nuclear receptor signaling: characterization of novel phosphoantibodies for estrogen receptor alpha. Nucl Recept Signal. 2006;4:e007 pubmed
  29. Koduri S, Goldhar A, Vonderhaar B. Activation of vascular endothelial growth factor (VEGF) by the ER-alpha variant, ERDelta3. Breast Cancer Res Treat. 2006;95:37-43 pubmed
  30. Fog C, Christensen I, Lykkesfeldt A. Characterization of a human breast cancer cell line, MCF-7/RU58R-1, resistant to the pure antiestrogen RU 58,668. Breast Cancer Res Treat. 2005;91:133-44 pubmed
  31. Ji Q, Liu P, Elshimali Y, Stolz A. Frequent loss of estrogen and progesterone receptors in human prostatic tumors determined by quantitative real-time PCR. Mol Cell Endocrinol. 2005;229:103-10 pubmed
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
headquarters: USA