product summary
request information :
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
ERalpha (F-10) Antibody
catalog :
sc-8002
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 79
  • western blot; human
Samaan S, Tranchevent L, Dardenne E, Polay Espinoza M, Zonta E, Germann S, et al. The Ddx5 and Ddx17 RNA helicases are cornerstones in the complex regulatory array of steroid hormone-signaling pathways. Nucleic Acids Res. 2014;42:2197-207 pubmed publisher
  • western blot; human; 1:200
Oguz Erdogan A, Ozdemirler N, Oyken M, Alper M, Erson-Bensan A. ARID3B expression in primary breast cancers and breast cancer-derived cell lines. Cell Oncol (Dordr). 2014;37:289-96 pubmed publisher
  • western blot; human; 1:400; fig 6
Jones L, Li M, Halama E, Ma Y, Lubet R, Grubbs C, et al. Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene. 2005;24:3554-62 pubmed
Shishido S, Faulkner E, Beck A, Nguyen T. The effect of antineoplastic drugs in a male spontaneous mammary tumor model. PLoS ONE. 2014;8:e64866 pubmed publisher
López-Romero R, Garrido-Guerrero E, Rangel-López A, Manuel-Apolinar L, Pina-Sanchez P, Lazos-Ochoa M, et al. The cervical malignant cells display a down regulation of ER-α but retain the ER-β expression. Int J Clin Exp Pathol. 2013;6:1594-602 pubmed
Wang L, Qiu X, Hao Q, Li D. Anti-inflammatory effects of a Chinese herbal medicine in atherosclerosis via estrogen receptor β mediating nitric oxide production and NF-κB suppression in endothelial cells. Cell Death Dis. 2013;4:e551 pubmed publisher
Guo W, Shiina I, Wang Y, Umeda E, Watanabe C, Uetake S, et al. Ridaifen-SB8, a novel tamoxifen derivative, induces apoptosis via reactive oxygen species-dependent signaling pathway. Biochem Pharmacol. 2013;86:1272-84 pubmed publisher
Caligiuri I, Toffoli G, Giordano A, Rizzolio F. pRb controls estrogen receptor alpha protein stability and activity. Oncotarget. 2013;4:875-83 pubmed
Lucchetti C, Caligiuri I, Toffoli G, Giordano A, Rizzolio F. The prolyl isomerase Pin1 acts synergistically with CDK2 to regulate the basal activity of estrogen receptor α in breast cancer. PLoS ONE. 2013;8:e55355 pubmed publisher
Akman B, Can T, Erson-Bensan A. Estrogen-induced upregulation and 3'-UTR shortening of CDC6. Nucleic Acids Res. 2012;40:10679-88 pubmed publisher
Burger R, Reith P, Kijanka G, Akujobi V, Abgrall P, Ducree J. Array-based capture, distribution, counting and multiplexed assaying of beads on a centrifugal microfluidic platform. Lab Chip. 2012;12:1289-95 pubmed publisher
O'Hara J, Varešlija D, McBryan J, Bane F, Tibbitts P, Byrne C, et al. AIB1:ERα transcriptional activity is selectively enhanced in aromatase inhibitor-resistant breast cancer cells. Clin Cancer Res. 2012;18:3305-15 pubmed publisher
Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 pubmed publisher
González-Arenas A, Hansberg-Pastor V, Hernández-Hernández O, González-García T, Henderson-Villalpando J, Lemus-Hernández D, et al. Estradiol increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators. Biochim Biophys Acta. 2012;1823:379-86 pubmed publisher
McBryan J, Theissen S, Byrne C, Hughes E, Cocchiglia S, Sande S, et al. Metastatic progression with resistance to aromatase inhibitors is driven by the steroid receptor coactivator SRC-1. Cancer Res. 2012;72:548-59 pubmed publisher
Svotelis A, Bianco S, Madore J, Huppé G, Nordell-Markovits A, Mes-Masson A, et al. H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERα ligand dependency. EMBO J. 2011;30:3947-61 pubmed publisher
Faratian D, Zweemer A, Nagumo Y, Sims A, Muir M, Dodds M, et al. Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies. Clin Cancer Res. 2011;17:4451-61 pubmed publisher
Wu X, Bogoni A, Yilmaz O, Nuccio S, Wang J, Willner A. Eightfold 40-320 Gbit/s phase-coherent multiplexing and 320-40 Gbit/s demultiplexing using highly nonlinear fibers. Opt Lett. 2010;35:1896-8 pubmed publisher
Lee G, Choi K, Han H, Jeung E. The classical and a non-classical pathways associated with NF-kappaB are involved in estrogen-mediated regulation of calbindin-D9k gene in rat pituitary cells. Mol Cell Endocrinol. 2007;277:42-50 pubmed
Gielen S, Hanekamp E, Hanifi-Moghaddam P, Sijbers A, van Gool A, Burger C, et al. Growth regulation and transcriptional activities of estrogen and progesterone in human endometrial cancer cells. Int J Gynecol Cancer. 2006;16:110-20 pubmed
Lee G, Kim H, Jung Y, Choi K, Jeung E. Estrogen receptor alpha pathway is involved in the regulation of Calbindin-D9k in the uterus of immature rats. Toxicol Sci. 2005;84:270-7 pubmed
Rao A, Ziegler Y, McLeod I, Yates J, Nardulli A. Effects of Cu/Zn superoxide dismutase on estrogen responsiveness and oxidative stress in human breast cancer cells. Mol Endocrinol. 2008;22:1113-24 pubmed publisher
Mc Ilroy M, Fleming F, Buggy Y, Hill A, Young L. Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence. Endocr Relat Cancer. 2006;13:1135-45 pubmed
El Marzouk S, Schultz-Norton J, Likhite V, McLeod I, Yates J, Nardulli A. Rho GDP dissociation inhibitor alpha interacts with estrogen receptor alpha and influences estrogen responsiveness. J Mol Endocrinol. 2007;39:249-59 pubmed
Creekmore A, Walt K, Schultz-Norton J, Ziegler Y, McLeod I, Yates J, et al. The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression. Mol Cell Endocrinol. 2008;291:79-86 pubmed publisher
Oviedo P, Hermenegildo C, Tarín J, Cano A. Raloxifene increases proliferation of human endothelial cells in association with increased gene expression of cyclins A and B1. Fertil Steril. 2007;88:326-32 pubmed
Curtis C, Likhite V, McLeod I, Yates J, Nardulli A. Interaction of the tumor metastasis suppressor nonmetastatic protein 23 homologue H1 and estrogen receptor alpha alters estrogen-responsive gene expression. Cancer Res. 2007;67:10600-7 pubmed
Naughton C, MacLeod K, Kuske B, Clarke R, Cameron D, Langdon S. Progressive loss of estrogen receptor alpha cofactor recruitment in endocrine resistance. Mol Endocrinol. 2007;21:2615-26 pubmed
Rokavec M, Schroth W, Amaral S, Fritz P, Antoniadou L, Glavac D, et al. A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer. Cancer Res. 2008;68:9799-808 pubmed publisher
Kalbe C, Mau M, Wollenhaupt K, Rehfeldt C. Evidence for estrogen receptor alpha and beta expression in skeletal muscle of pigs. Histochem Cell Biol. 2007;127:95-107 pubmed
Di Leva G, Gasparini P, Piovan C, Ngankeu A, Garofalo M, Taccioli C, et al. MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer. J Natl Cancer Inst. 2010;102:706-21 pubmed publisher
Colin C, Salamone S, Grillier-Vuissoz I, Boisbrun M, Kuntz S, Lecomte J, et al. New troglitazone derivatives devoid of PPARγ agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines. Breast Cancer Res Treat. 2010;124:101-10 pubmed publisher
Gielen S, Burger C, Kuhne L, Hanifi-Moghaddam P, Blok L. Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005;12:e55-67 pubmed
Hanifi-Moghaddam P, Sijmons B, Ott M, van Ijcken W, Nowzari D, Kuhne E, et al. The hormone replacement therapy drug tibolone acts very similar to medroxyprogesterone acetate in an estrogen-and progesterone-responsive endometrial cancer cell line. J Mol Endocrinol. 2006;37:405-13 pubmed
Ushmorov A, Hogarty M, Liu X, Knauss H, Debatin K, Beltinger C. N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells. Oncogene. 2008;27:3424-34 pubmed publisher
Dillon M, Stafford A, Kelly G, Redmond A, McIlroy M, Crotty T, et al. Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. Endocr Relat Cancer. 2008;15:745-53 pubmed publisher
Barone M, Scavo M, Papagni S, Piscitelli D, Guido R, Di Lena M, et al. ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis. Scand J Gastroenterol. 2010;45:1320-8 pubmed publisher
Mao C, Patterson N, Cherian M, Aninye I, Zhang C, Montoya J, et al. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. J Biol Chem. 2008;283:12819-30 pubmed publisher
He H, Zhu T, Xie Y, Fan J, Kole S, Saxena S, et al. Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes. J Biol Chem. 2006;281:31369-79 pubmed
Baquedano M, Saraco N, Berensztein E, Pepe C, Bianchini M, Levy E, et al. Identification and developmental changes of aromatase and estrogen receptor expression in prepubertal and pubertal human adrenal tissues. J Clin Endocrinol Metab. 2007;92:2215-22 pubmed
Wang C, Koay D, Edwards A, Lu Z, Mor G, Ocal I, et al. In vitro and in vivo effects of combination of Trastuzumab (Herceptin) and Tamoxifen in breast cancer. Breast Cancer Res Treat. 2005;92:251-63 pubmed
Schultz-Norton J, Ziegler Y, Likhite V, Yates J, Nardulli A. Isolation of novel coregulatory protein networks associated with DNA-bound estrogen receptor alpha. BMC Mol Biol. 2008;9:97 pubmed publisher
Vo T, Jeung E. An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model. Toxicol Sci. 2009;112:68-77 pubmed publisher
Sobrino A, Mata M, Laguna-Fernandez A, Novella S, Oviedo P, García-Pérez M, et al. Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells. PLoS ONE. 2009;4:e8242 pubmed publisher
Sobrino A, Oviedo P, Novella S, Laguna-Fernandez A, Bueno C, García-Pérez M, et al. Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}. J Mol Endocrinol. 2010;44:237-46 pubmed publisher
Schultz-Norton J, Walt K, Ziegler Y, McLeod I, Yates J, Raetzman L, et al. The deoxyribonucleic acid repair protein flap endonuclease-1 modulates estrogen-responsive gene expression. Mol Endocrinol. 2007;21:1569-80 pubmed
Kuske B, Naughton C, Moore K, MacLeod K, Miller W, Clarke R, et al. Endocrine therapy resistance can be associated with high estrogen receptor alpha (ERalpha) expression and reduced ERalpha phosphorylation in breast cancer models. Endocr Relat Cancer. 2006;13:1121-33 pubmed
Seow H, Yip W, Loh H, Ithnin H, Por P, Rohaizak M. Immunohistochemical detection of phospho-Akt, phospho-BAD, HER2 and oestrogen receptors alpha and beta in Malaysian breast cancer patients. Pathol Oncol Res. 2010;16:239-48 pubmed publisher
Creekmore A, Ziegler Y, Bonéy J, Nardulli A. Estrogen receptor alpha regulates expression of the breast cancer 1 associated ring domain 1 (BARD1) gene through intronic DNA sequence. Mol Cell Endocrinol. 2007;267:106-15 pubmed
Kameda C, Nakamura M, Tanaka H, Yamasaki A, Kubo M, Tanaka M, et al. Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. Br J Cancer. 2010;102:738-47 pubmed publisher
Han Y, Feng H, Sandlow J, Haines C. Comparing expression of progesterone and estrogen receptors in testicular tissue from men with obstructive and nonobstructive azoospermia. J Androl. 2009;30:127-33 pubmed publisher
Berensztein E, Baquedano M, Gonzalez C, Saraco N, Rodriguez J, Ponzio R, et al. Expression of aromatase, estrogen receptor alpha and beta, androgen receptor, and cytochrome P-450scc in the human early prepubertal testis. Pediatr Res. 2006;60:740-4 pubmed
Cho M, Lee M, Nam K, Chung W, Park C, Lee J, et al. Expression and role of estrogen receptor alpha and beta in medullary thyroid carcinoma: different roles in cancer growth and apoptosis. J Endocrinol. 2007;195:255-63 pubmed
Vo T, Jung E, Choi K, Yu F, Jeung E. Estrogen receptor α is involved in the induction of Calbindin-D(9k) and progesterone receptor by parabens in GH3 cells: a biomarker gene for screening xenoestrogens. Steroids. 2011;76:675-81 pubmed publisher
Dahm A, Iversen N, Birkenes B, Ree A, Sandset P. Estrogens, selective estrogen receptor modulators, and a selective estrogen receptor down-regulator inhibit endothelial production of tissue factor pathway inhibitor 1. BMC Cardiovasc Disord. 2006;6:40 pubmed
Nagayama K, Sasaki S, Matsushita A, Ohba K, Iwaki H, Matsunaga H, et al. Inhibition of GATA2-dependent transactivation of the TSHbeta gene by ligand-bound estrogen receptor alpha. J Endocrinol. 2008;199:113-25 pubmed publisher
Li X, Mertens-Talcott S, Zhang S, Kim K, Ball J, Safe S. MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells. Endocrinology. 2010;151:2462-73 pubmed publisher
Ranjit S, Khair L, Linehan E, Ucher A, Chakrabarti M, Schrader C, et al. AID recruits UNG and Msh2 to Ig switch regions dependent upon the AID C terminus [corrected]. J Immunol. 2011;187:2464-75 pubmed publisher
Sadikovic B, Rodenhiser D. Benzopyrene exposure disrupts DNA methylation and growth dynamics in breast cancer cells. Toxicol Appl Pharmacol. 2006;216:458-68 pubmed
Lecomte J, Flament S, Salamone S, Boisbrun M, Mazerbourg S, Chapleur Y, et al. Disruption of ERalpha signalling pathway by PPARgamma agonists: evidences of PPARgamma-independent events in two hormone-dependent breast cancer cell lines. Breast Cancer Res Treat. 2008;112:437-51 pubmed publisher
Schultz-Norton J, Ziegler Y, Likhite V, Nardulli A. Isolation of proteins associated with the DNA-bound estrogen receptor alpha. Methods Mol Biol. 2009;590:209-21 pubmed publisher
Rao A, Ziegler Y, McLeod I, Yates J, Nardulli A. Thioredoxin and thioredoxin reductase influence estrogen receptor alpha-mediated gene expression in human breast cancer cells. J Mol Endocrinol. 2009;43:251-61 pubmed publisher
Ren Y, Wu L, Frost A, Grizzle W, Cao X, Wan M. Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancer. Mol Cancer. 2009;8:111 pubmed publisher
Henning K, Heering J, Schwanbeck R, Schroeder T, Helmbold H, Schafer H, et al. Notch1 activation reduces proliferation in the multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53. Cell Death Differ. 2008;15:398-407 pubmed
Schultz-Norton J, Gabisi V, Ziegler Y, McLeod I, Yates J, Nardulli A. Interaction of estrogen receptor alpha with proliferating cell nuclear antigen. Nucleic Acids Res. 2007;35:5028-38 pubmed
Liu J, Xie Y, Merrick B, Shen J, Ducharme D, Collins J, et al. Transplacental arsenic plus postnatal 12-O-teradecanoyl phorbol-13-acetate exposures associated with hepatocarcinogenesis induce similar aberrant gene expression patterns in male and female mouse liver. Toxicol Appl Pharmacol. 2006;213:216-23 pubmed
Hernández-Hernández O, Rodríguez-Dorantes M, González-Arenas A, Camacho-Arroyo I. Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines. Endocrine. 2010;37:194-200 pubmed publisher
Penatti C, Porter D, Henderson L. Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms. J Neurosci. 2009;29:12484-96 pubmed publisher
Aubé M, Larochelle C, Ayotte P. Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines. Environ Res. 2011;111:337-47 pubmed publisher
Keimling M, Kaur J, Bagadi S, Kreienberg R, Wiesmuller L, Ralhan R. A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens. Int J Cancer. 2008;123:730-6 pubmed publisher
Kita K, Jin Y, Sun Z, Chen S, Sumiya Y, Hongo T, et al. Increase in the levels of chaperone proteins by exposure to beta-estradiol, bisphenol A and 4-methoxyphenol in human cells transfected with estrogen receptor alpha cDNA. Toxicol In Vitro. 2009;23:728-35 pubmed publisher
Sharma I, Dhawan V, Mahajan N, Saha S, Dhaliwal L. In vitro effects of atorvastatin on lipopolysaccharide-induced gene expression in endometriotic stromal cells. Fertil Steril. 2010;94:1639-46.e1 pubmed publisher
Schultz J, Petz L, Nardulli A. Cell- and ligand-specific regulation of promoters containing activator protein-1 and Sp1 sites by estrogen receptors alpha and beta. J Biol Chem. 2005;280:347-54 pubmed
Bonéy-Montoya J, Ziegler Y, Curtis C, Montoya J, Nardulli A. Long-range transcriptional control of progesterone receptor gene expression. Mol Endocrinol. 2010;24:346-58 pubmed publisher
Villamar-Cruz O, Manjarrez-Marmolejo J, Alvarado R, Camacho-Arroyo I. Regulation of the content of progesterone and estrogen receptors, and their cofactors SRC-1 and SMRT by the 26S proteasome in the rat brain during the estrous cycle. Brain Res Bull. 2006;69:276-81 pubmed
Schultz-Norton J, McDonald W, Yates J, Nardulli A. Protein disulfide isomerase serves as a molecular chaperone to maintain estrogen receptor alpha structure and function. Mol Endocrinol. 2006;20:1982-95 pubmed
Massinen S, Tammimies K, Tapia-Paez I, Matsson H, Hokkanen M, Söderberg O, et al. Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia. Hum Mol Genet. 2009;18:2802-12 pubmed publisher
Zhou D, Ye J, Li Y, Lui K, Chen S. The molecular basis of the interaction between the proline-rich SH3-binding motif of PNRC and estrogen receptor alpha. Nucleic Acids Res. 2006;34:5974-86 pubmed
Wang A, Ji L, Shang W, Li M, Chen L, White R, et al. Expression of GPR30, ERα and ERβ in endometrium during window of implantation in patients with polycystic ovary syndrome: a pilot study. Gynecol Endocrinol. 2011;27:251-5 pubmed publisher
product information
product name :
ERalpha (F-10) Antibody
gene name :
ESR1
size :
200 µg/ml
price :
279 USD
catalog number :
sc-8002
type :
Monoclonal
host :
mouse monoclonal
antigen :
ERalpha
reactive species  :
human
applications :
WB, IP, PAR, ELISA
epitope :
C-terminal (h)
delivery :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
www.scbt.com
1.800.457.3801
headquarters: USA