product summary
request information :
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
ERalpha (F-10)
catalog :
sc-8002
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
immunohistochemistry - paraffin section, western blot, ELISA, immunoprecipitation, immunohistochemistry, immunocytochemistry
publications citing this reagent :
total: 78
- Akman B, Can T, Erson-Bensan A. Estrogen-induced upregulation and 3'-UTR shortening of CDC6. Nucleic Acids Res. 2012;40:10679-88 PMID 22977174
- Guido C, Panza S, Santoro M, Avena P, Panno M, Perrotta I, et al. Estrogen receptor beta (ERβ) produces autophagy and necroptosis in human seminoma cell line through the binding of the Sp1 on the phosphatase and tensin homolog deleted from chromosome 10 (PTEN) promoter gene. Cell Cycle. 2012;11:2911-21 PMID 22810004
- O'Hara J, Varešlija D, McBryan J, Bane F, Tibbitts P, Byrne C, et al. AIB1:ERα transcriptional activity is selectively enhanced in aromatase inhibitor-resistant breast cancer cells. Clin Cancer Res. 2012;18:3305-15 PMID 22550166
- Burger R, Reith P, Kijanka G, Akujobi V, Abgrall P, Ducree J. Array-based capture, distribution, counting and multiplexed assaying of beads on a centrifugal microfluidic platform. Lab Chip. 2012;12:1289-95 PMID 22334354
- González-Arenas A, Hansberg-Pastor V, Hernández-Hernández O, González-García T, Henderson-Villalpando J, Lemus-Hernández D, et al. Estradiol increases cell growth in human astrocytoma cell lines through ERα activation and its interaction with SRC-1 and SRC-3 coactivators. Biochim Biophys Acta. 2012;1823:379-86 PMID 22142990
- McBryan J, Theissen S, Byrne C, Hughes E, Cocchiglia S, Sande S, et al. Metastatic progression with resistance to aromatase inhibitors is driven by the steroid receptor coactivator SRC-1. Cancer Res. 2012;72:548-59 PMID 22108824
- Svotelis A, Bianco S, Madore J, Huppé G, Nordell-Markovits A, Mes-Masson A, et al. H3K27 demethylation by JMJD3 at a poised enhancer of anti-apoptotic gene BCL2 determines ERα ligand dependency. EMBO J. 2011;30:3947-61 PMID 21841772
- Ranjit S, Khair L, Linehan E, Ucher A, Chakrabarti M, Schrader C, et al. AID binds cooperatively with UNG and Msh2-Msh6 to Ig switch regions dependent upon the AID C terminus. J Immunol. 2011;187:2464-75 PMID 21804017
- Faratian D, Zweemer A, Nagumo Y, Sims A, Muir M, Dodds M, et al. Trastuzumab and pertuzumab produce changes in morphology and estrogen receptor signaling in ovarian cancer xenografts revealing new treatment strategies. Clin Cancer Res. 2011;17:4451-61 PMID 21571868
- Vo T, Jung E, Choi K, Yu F, Jeung E. Estrogen receptor α is involved in the induction of Calbindin-D(9k) and progesterone receptor by parabens in GH3 cells: a biomarker gene for screening xenoestrogens. Steroids. 2011;76:675-81 PMID 21473877
more info or order :
product information
product name :
ERalpha (F-10)
Gene Name :
ESR1
Size :
200 µg/ml
price :
279 USD
catalog number :
sc-8002
type :
monoclonal
host :
mouse monoclonal
Antigen :
ERalpha
reactive species :
human
application :
WB, IP, IF, IHC(P), ELISA
Epitope :
C-terminus (h)
Delivery Time :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
publications citing this reagent :
- Aubé M, Larochelle C, Ayotte P. Differential effects of a complex organochlorine mixture on the proliferation of breast cancer cell lines. Environ Res. 2011;111:337-47 PMID 21295777
- Hernández-Hernández O, Rodríguez-Dorantes M, González-Arenas A, Camacho-Arroyo I. Progesterone and estradiol effects on SRC-1 and SRC-3 expression in human astrocytoma cell lines. Endocrine. 2010;37:194-200 PMID 20963570
- Wu X, Bogoni A, Yilmaz O, Nuccio S, Wang J, Willner A. Eightfold 40-320 Gbit/s phase-coherent multiplexing and 320-40 Gbit/s demultiplexing using highly nonlinear fibers. Opt Lett. 2010;35:1896-8 PMID 20517454
- Barone M, Scavo M, Papagni S, Piscitelli D, Guido R, Di Lena M, et al. ERβ expression in normal, adenomatous and carcinomatous tissues of patients with familial adenomatous polyposis. Scand J Gastroenterol. 2010;45:1320-8 PMID 20446826
- Di Leva G, Gasparini P, Piovan C, Ngankeu A, Garofalo M, Taccioli C, et al. MicroRNA cluster 221-222 and estrogen receptor alpha interactions in breast cancer. J Natl Cancer Inst. 2010;102:706-21 PMID 20388878
- Li X, Mertens-Talcott S, Zhang S, Kim K, Ball J, Safe S. MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells. Endocrinology. 2010;151:2462-73 PMID 20382698
- Sobrino A, Oviedo P, Novella S, Laguna-Fernandez A, Bueno C, García-Pérez M, et al. Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}. J Mol Endocrinol. 2010;44:237-46 PMID 20110403
- Kameda C, Nakamura M, Tanaka H, Yamasaki A, Kubo M, Tanaka M, et al. Oestrogen receptor-alpha contributes to the regulation of the hedgehog signalling pathway in ERalpha-positive gastric cancer. Br J Cancer. 2010;102:738-47 PMID 20087349
- Colin C, Salamone S, Grillier-Vuissoz I, Boisbrun M, Kuntz S, Lecomte J, et al. New troglitazone derivatives devoid of PPARγ agonist activity display an increased antiproliferative effect in both hormone-dependent and hormone-independent breast cancer cell lines. Breast Cancer Res Treat. 2010;124:101-10 PMID 20054646
- Sobrino A, Mata M, Laguna-Fernandez A, Novella S, Oviedo P, García-Pérez M, et al. Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells. PLoS ONE. 2009;4:e8242 PMID 20011585
- Bonéy-Montoya J, Ziegler Y, Curtis C, Montoya J, Nardulli A. Long-range transcriptional control of progesterone receptor gene expression. Mol Endocrinol. 2010;24:346-58 PMID 19952285
- Sharma I, Dhawan V, Mahajan N, Saha S, Dhaliwal L. In vitro effects of atorvastatin on lipopolysaccharide-induced gene expression in endometriotic stromal cells. Fertil Steril. 2010;94:1639-46.e1 PMID 19944411
- Ren Y, Wu L, Frost A, Grizzle W, Cao X, Wan M. Dual effects of TGF-beta on ERalpha-mediated estrogenic transcriptional activity in breast cancer. Mol Cancer. 2009;8:111 PMID 19943940
- Seow H, Yip W, Loh H, Ithnin H, Por P, Rohaizak M. Immunohistochemical detection of phospho-Akt, phospho-BAD, HER2 and oestrogen receptors alpha and beta in Malaysian breast cancer patients. Pathol Oncol Res. 2010;16:239-48 PMID 19882362
- Penatti C, Porter D, Henderson L. Chronic exposure to anabolic androgenic steroids alters neuronal function in the mammalian forebrain via androgen receptor- and estrogen receptor-mediated mechanisms. J Neurosci. 2009;29:12484-96 PMID 19812324
- Schultz-Norton J, Ziegler Y, Likhite V, Nardulli A. Isolation of proteins associated with the DNA-bound estrogen receptor alpha. Methods Mol Biol. 2009;590:209-21 PMID 19763506
- Vo T, Jeung E. An evaluation of estrogenic activity of parabens using uterine calbindin-d9k gene in an immature rat model. Toxicol Sci. 2009;112:68-77 PMID 19654335
- Rao A, Ziegler Y, McLeod I, Yates J, Nardulli A. Thioredoxin and thioredoxin reductase influence estrogen receptor alpha-mediated gene expression in human breast cancer cells. J Mol Endocrinol. 2009;43:251-61 PMID 19620238
- Massinen S, Tammimies K, Tapia-Paez I, Matsson H, Hokkanen M, Söderberg O, et al. Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia. Hum Mol Genet. 2009;18:2802-12 PMID 19423554
- Kita K, Jin Y, Sun Z, Chen S, Sumiya Y, Hongo T, et al. Increase in the levels of chaperone proteins by exposure to beta-estradiol, bisphenol A and 4-methoxyphenol in human cells transfected with estrogen receptor alpha cDNA. Toxicol In Vitro. 2009;23:728-35 PMID 19269315
- Rokavec M, Schroth W, Amaral S, Fritz P, Antoniadou L, Glavac D, et al. A polymorphism in the TC21 promoter associates with an unfavorable tamoxifen treatment outcome in breast cancer. Cancer Res. 2008;68:9799-808 PMID 19047159
- Schultz-Norton J, Ziegler Y, Likhite V, Yates J, Nardulli A. Isolation of novel coregulatory protein networks associated with DNA-bound estrogen receptor alpha. BMC Mol Biol. 2008;9:97 PMID 18973695
- Han Y, Feng H, Sandlow J, Haines C. Comparing expression of progesterone and estrogen receptors in testicular tissue from men with obstructive and nonobstructive azoospermia. J Androl. 2009;30:127-33 PMID 18835831
- Nagayama K, Sasaki S, Matsushita A, Ohba K, Iwaki H, Matsunaga H, et al. Inhibition of GATA2-dependent transactivation of the TSHbeta gene by ligand-bound estrogen receptor alpha. J Endocrinol. 2008;199:113-25 PMID 18653622
- Creekmore A, Walt K, Schultz-Norton J, Ziegler Y, McLeod I, Yates J, et al. The role of retinoblastoma-associated proteins 46 and 48 in estrogen receptor alpha mediated gene expression. Mol Cell Endocrinol. 2008;291:79-86 PMID 18577416
- Keimling M, Kaur J, Bagadi S, Kreienberg R, Wiesmuller L, Ralhan R. A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens. Int J Cancer. 2008;123:730-6 PMID 18491400
- Dillon M, Stafford A, Kelly G, Redmond A, McIlroy M, Crotty T, et al. Cyclooxygenase-2 predicts adverse effects of tamoxifen: a possible mechanism of role for nuclear HER2 in breast cancer patients. Endocr Relat Cancer. 2008;15:745-53 PMID 18469157
- Mao C, Patterson N, Cherian M, Aninye I, Zhang C, Montoya J, et al. A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells. J Biol Chem. 2008;283:12819-30 PMID 18337247
- WBRao A, Ziegler Y, McLeod I, Yates J, Nardulli A. Effects of Cu/Zn superoxide dismutase on estrogen responsiveness and oxidative stress in human breast cancer cells. Mol Endocrinol. 2008;22:1113-24 PMID 18258688
- Lecomte J, Flament S, Salamone S, Boisbrun M, Mazerbourg S, Chapleur Y, et al. Disruption of ERalpha signalling pathway by PPARgamma agonists: evidences of PPARgamma-independent events in two hormone-dependent breast cancer cell lines. Breast Cancer Res Treat. 2008;112:437-51 PMID 18204896
- Ushmorov A, Hogarty M, Liu X, Knauss H, Debatin K, Beltinger C. N-myc augments death and attenuates protective effects of Bcl-2 in trophically stressed neuroblastoma cells. Oncogene. 2008;27:3424-34 PMID 18193081
- Henning K, Heering J, Schwanbeck R, Schroeder T, Helmbold H, Schafer H, et al. Notch1 activation reduces proliferation in the multipotent hematopoietic progenitor cell line FDCP-mix through a p53-dependent pathway but Notch1 effects on myeloid and erythroid differentiation are independent of p53. Cell Death Differ. 2008;15:398-407 PMID 18049480
- Curtis C, Likhite V, McLeod I, Yates J, Nardulli A. Interaction of the tumor metastasis suppressor nonmetastatic protein 23 homologue H1 and estrogen receptor alpha alters estrogen-responsive gene expression. Cancer Res. 2007;67:10600-7 PMID 17975005
- Lim S, Nam K, Cho M, Lee M, Nam K, Chung W, et al. Expression and role of estrogen receptor alpha and beta in medullary thyroid carcinoma: different roles in cancer growth and apoptosis. J Endocrinol. 2007;195:255-63 PMID 17951536
- El Marzouk S, Schultz-Norton J, Likhite V, McLeod I, Yates J, Nardulli A. Rho GDP dissociation inhibitor alpha interacts with estrogen receptor alpha and influences estrogen responsiveness. J Mol Endocrinol. 2007;39:249-59 PMID 17909265
- Han H, Lee G, Choi K, Jeung E, Lee G, Choi K, et al. The classical and a non-classical pathways associated with NF-kappaB are involved in estrogen-mediated regulation of calbindin-D9k gene in rat pituitary cells. Mol Cell Endocrinol. 2007;277:42-50 PMID 17825480
- Naughton C, MacLeod K, Kuske B, Clarke R, Cameron D, Langdon S. Progressive loss of estrogen receptor alpha cofactor recruitment in endocrine resistance. Mol Endocrinol. 2007;21:2615-26 PMID 17666584
- Schultz-Norton J, Gabisi V, Ziegler Y, McLeod I, Yates J, Nardulli A. Interaction of estrogen receptor alpha with proliferating cell nuclear antigen. Nucleic Acids Res. 2007;35:5028-38 PMID 17636311
- Schultz-Norton J, Walt K, Ziegler Y, McLeod I, Yates J, Raetzman L, et al. The deoxyribonucleic acid repair protein flap endonuclease-1 modulates estrogen-responsive gene expression. Mol Endocrinol. 2007;21:1569-80 PMID 17488975
- WBBaquedano M, Saraco N, Berensztein E, Pepe C, Bianchini M, Levy E, et al. Identification and developmental changes of aromatase and estrogen receptor expression in prepubertal and pubertal human adrenal tissues. J Clin Endocrinol Metab. 2007;92:2215-22 PMID 17405842
- Creekmore A, Ziegler Y, Bonéy J, Nardulli A. Estrogen receptor alpha regulates expression of the breast cancer 1 associated ring domain 1 (BARD1) gene through intronic DNA sequence. Mol Cell Endocrinol. 2007;267:106-15 PMID 17275994
- Hanifi-Moghaddam P, Sijmons B, Ott M, van Ijcken W, Nowzari D, Kuhne E, et al. The hormone replacement therapy drug tibolone acts very similar to medroxyprogesterone acetate in an estrogen-and progesterone-responsive endometrial cancer cell line. J Mol Endocrinol. 2006;37:405-13 PMID 17170081
- Mc Ilroy M, Fleming F, Buggy Y, Hill A, Young L. Tamoxifen-induced ER-alpha-SRC-3 interaction in HER2 positive human breast cancer; a possible mechanism for ER isoform specific recurrence. Endocr Relat Cancer. 2006;13:1135-45 PMID 17158759
- Cameron D, Clarke R, Miller W, Moore K, Langdon S, Naughton C, et al. Endocrine therapy resistance can be associated with high estrogen receptor alpha (ERalpha) expression and reduced ERalpha phosphorylation in breast cancer models. Endocr Relat Cancer. 2006;13:1121-33 PMID 17158758
- Chen S, Zhou D, Ye J, Li Y, Lui K. The molecular basis of the interaction between the proline-rich SH3-binding motif of PNRC and estrogen receptor alpha. Nucleic Acids Res. 2006;34:5974-86 PMID 17068076
- Berensztein E, Baquedano M, Gonzalez C, Saraco N, Rodriguez J, Ponzio R, et al. Expression of aromatase, estrogen receptor alpha and beta, androgen receptor, and cytochrome P-450scc in the human early prepubertal testis. Pediatr Res. 2006;60:740-4 PMID 17065579
- Dahm A, Iversen N, Birkenes B, Ree A, Sandset P. Estrogens, selective estrogen receptor modulators, and a selective estrogen receptor down-regulator inhibit endothelial production of tissue factor pathway inhibitor 1. BMC Cardiovasc Disord. 2006;6:40 PMID 17029634
- He H, Zhu T, He H, Zhu T, Xie Y, Fan J, et al. Pyrrolidine dithiocarbamate inhibits interleukin-6 signaling through impaired STAT3 activation and association with transcriptional coactivators in hepatocytes. J Biol Chem. 2006;281:31369-79 PMID 16926159
- Sadikovic B, Rodenhiser D. Benzopyrene exposure disrupts DNA methylation and growth dynamics in breast cancer cells. Toxicol Appl Pharmacol. 2006;216:458-68 PMID 16926039
- Kalbe C, Mau M, Wollenhaupt K, Rehfeldt C. Evidence for estrogen receptor alpha and beta expression in skeletal muscle of pigs. Histochem Cell Biol. 2007;127:95-107 PMID 16897031
- Schultz-Norton J, McDonald W, Yates J, Nardulli A. Protein disulfide isomerase serves as a molecular chaperone to maintain estrogen receptor alpha structure and function. Mol Endocrinol. 2006;20:1982-95 PMID 16690750
- Villamar-Cruz O, Manjarrez-Marmolejo J, Alvarado R, Camacho-Arroyo I. Regulation of the content of progesterone and estrogen receptors, and their cofactors SRC-1 and SMRT by the 26S proteasome in the rat brain during the estrous cycle. Brain Res Bull. 2006;69:276-81 PMID 16564422
- Sijbers A, van Gool A, Hanifi-Moghaddam P, Gielen S, Burger C, Blok L, et al. Growth regulation and transcriptional activities of estrogen and progesterone in human endometrial cancer cells. Int J Gynecol Cancer. 2006;16:110-20 PMID 16445620
- Burger C, Blok L, Gielen S, Hanifi-Moghaddam P. Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005;12:e55-67 PMID 16202921
- Deng C, Jones L, Li M, Halama E, Ma Y, Lubet R, et al. Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene. 2005;24:3554-62 PMID 15750629
- Etique N, Chardard D, Chesnel A, Flament S, Grillier-Vuissoz I. Analysis of the effects of different alcohols on MCF-7 human breast cancer cells. Ann N Y Acad Sci. 2004;1030:78-85 PMID 15659783
- Lee G, Kim H, Jung Y, Choi K, Jeung E, Lee G, et al. Estrogen receptor alpha pathway is involved in the regulation of Calbindin-D9k in the uterus of immature rats. Toxicol Sci. 2005;84:270-7 PMID 15635152
- Schultz J, Petz L, Nardulli A. Cell- and ligand-specific regulation of promoters containing activator protein-1 and Sp1 sites by estrogen receptors alpha and beta. J Biol Chem. 2005;280:347-54 PMID 15509581
- Petz L, Ziegler Y, Schultz J, Kim H, Kemper J, Nardulli A. Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sites. J Steroid Biochem Mol Biol. 2004;88:113-22 PMID 15084343
- Likhite V, Cass E, Anderson S, Yates J, Nardulli A. Interaction of estrogen receptor alpha with 3-methyladenine DNA glycosylase modulates transcription and DNA repair. J Biol Chem. 2004;279:16875-82 PMID 14761960
- Petz L, Ziegler Y, Schultz J, Nardulli A. Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site. Mol Endocrinol. 2004;18:521-32 PMID 14684847
- Schultz J, Petz L, Nardulli A. Estrogen receptor alpha and Sp1 regulate progesterone receptor gene expression. Mol Cell Endocrinol. 2003;201:165-75 PMID 12706304
- Morales A, Duarte-Rojo A, Angeles-Angeles A, Mery C, Ruiz-Molina J, Díaz-Sánchez V, et al. The beta form of the estrogen receptor is predominantly expressed in the papillary cystic neoplasm of the pancreas. Pancreas. 2003;26:258-63 PMID 12657952
- Petz L, Ziegler Y, Loven M, Nardulli A. Estrogen receptor alpha and activating protein-1 mediate estrogen responsiveness of the progesterone receptor gene in MCF-7 breast cancer cells. Endocrinology. 2002;143:4583-91 PMID 12446585
- Greenberger L, Annable T, Collins K, Komm B, Lyttle C, Miller C, et al. A new antiestrogen, 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-piperidin-1-yl-ethoxy)-benzyl]-1H-indol-5-ol hydrochloride (ERA-923), inhibits the growth of tamoxifen-sensitive and -resistant tumors and is devoid of uterotropic effects in mice and rats. Clin Cancer Res. 2001;7:3166-77 PMID 11595711
- Jankowski M, Rachelska G, Donghao W, McCann S, Gutkowska J. Estrogen receptors activate atrial natriuretic peptide in the rat heart. Proc Natl Acad Sci U S A. 2001;98:11765-70 PMID 11562484
- Chiang C, Cheng K, Igarashi S, Nathwani P, Leung P. Hormonal regulation of estrogen receptor alpha and beta gene expression in human granulosa-luteal cells in vitro. J Clin Endocrinol Metab. 2000;85:3828-39 PMID 11061546
- Schroeder T, Just U. Notch signalling via RBP-J promotes myeloid differentiation. EMBO J. 2000;19:2558-68 PMID 10835354
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