product summary
request information :
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Akt1 (B-1) Antibody
catalog :
sc-5298
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
reactivity :
human, rat, mouse
application :
western blot, ELISA, immunoprecipitation, immunocytochemistry, flow cytometry
publications citing this reagent :
total: 39
  1. Liu N, Xi Y, Callaghan M, Fribley A, Moore-Smith L, Zimmerman J, et al. SMAD4 is a potential prognostic marker in human breast carcinomas. Tumour Biol. 2014;35:641-50 pubmed
  2. Fekete A, B Gel G, Pesti S, Péterfi Z, Geiszt M, Buday L. EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5. J Mol Signal. 2013;8:8 pubmed
  3. Bogazzi F, Raggi F, Russo D, Bohlooly-Y M, Sardella C, Urbani C, et al. Growth hormone is necessary for the p53-mediated, obesity-induced insulin resistance in male C57BL/6J x CBA mice. Endocrinology. 2013;154:4226-36 pubmed publisher
  4. Yang Y, Li X, Wang L, Han S, Zhang Y, Pratheeshkumar P, et al. Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells. Int J Oncol. 2013;43:936-46 pubmed publisher
  5. Son Y, Pratheeshkumar P, Wang L, Wang X, Fan J, Kim D, et al. Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling. Toxicol Appl Pharmacol. 2013;271:239-48 pubmed publisher
  6. Murugan A, Alzahrani A, Xing M. Mutations in critical domains confer the human mTOR gene strong tumorigenicity. J Biol Chem. 2013;288:6511-21 pubmed
  7. Cai N, Wang Y, Zheng P. The microRNA-302-367 cluster suppresses the proliferation of cervical carcinoma cells through the novel target AKT1. RNA. 2013;19:85-95 pubmed publisher
  8. Blich M, Golan A, Arvatz G, Sebbag A, Shafat I, Sabo E, et al. Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression. Arterioscler Thromb Vasc Biol. 2013;33:e56-65 pubmed publisher
  9. Booher K, Lin D, Borrego S, Kaiser P. Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells. Cell Cycle. 2012;11:4414-23 pubmed publisher
  10. Son Y, Wang L, Poyil P, Budhraja A, Hitron J, Zhang Z, et al. Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling. Toxicol Appl Pharmacol. 2012;264:153-60 pubmed
product information
product name :
Akt1 (B-1) Antibody
gene name :
AKT1, AKT2, AKT3
size :
200 µg/ml
price :
279 USD
catalog number :
sc-5298
type :
Monoclonal
host :
mouse monoclonal
antigen :
Akt1
reactive species :
m, r, h
applications :
WB, IP, IF, FCM, ELISA
epitope :
345-480 (h)
delivery :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
publications citing this reagent :
  1. Song S, Lee M, Lee J, Jeong H, Kim H, Kim W, et al. Genetic modification of human adipose-derived stem cells for promoting wound healing. J Dermatol Sci. 2012;66:98-107 pubmed
  2. Hung S, Chiang H, Wu C, Hsu M, Chen Y. Effects of herpes simplex virus type 1 infection on immune functions of human neutrophils. J Periodontal Res. 2012;47:635-44 pubmed
  3. Ali I, Damdimopoulou P, Stenius U, Adamsson A, Mäkelä S, Akesson A, et al. Cadmium-induced effects on cellular signaling pathways in the liver of transgenic estrogen reporter mice. Toxicol Sci. 2012;127:66-75 pubmed
  4. Cohen-Kaplan V, Jrbashyan J, Yanir Y, Naroditsky I, Ben-Izhak O, Ilan N, et al. Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer. J Biol Chem. 2012;287:6668-78 pubmed publisher
  5. Nagel J, Brinkoetter M, Magkos F, Liu X, Chamberland J, Shah S, et al. Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition. 2012;28:67-75 pubmed publisher
  6. Lin W, Rahman N, Lin J, Zhang H, Gou K, Yu W, et al. Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1). Am J Pathol. 2011;178:1233-44 pubmed publisher
  7. Zhang L, Sun S, Zhou J, Liu J, Lv J, Yu X, et al. Knockdown of Akt1 promotes Akt2 upregulation and resistance to oxidative-stress-induced apoptosis through control of multiple signaling pathways. Antioxid Redox Signal. 2011;15:1-17 pubmed publisher
  8. Mukherjee A, Badal Y, Nguyen X, Miller J, Chenna A, Tahir H, et al. Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteins. PLoS ONE. 2011;6:e16443 pubmed publisher
  9. Leksa V, Loewe R, Binder B, Schiller H, Eckerstorfer P, Forster F, et al. Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation. Circ Res. 2011;108:676-85 pubmed publisher
  10. Motegi H, Shimo Y, Akiyama T, Inoue J. TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling. Genes Cells. 2011;16:179-89 pubmed publisher
  11. Zhang W, Lee J, Kim I, Kim Y, Park J, Myung C. 7-O-methylaromadendrin stimulates glucose uptake and improves insulin resistance in vitro. Biol Pharm Bull. 2010;33:1494-9 pubmed
  12. Voutsadakis I, Patrikidou A, Tsapakidis K, Karagiannaki A, Hatzidaki E, Stathakis N, et al. Additive inhibition of colorectal cancer cell lines by aspirin and bortezomib. Int J Colorectal Dis. 2010;25:795-804 pubmed
  13. Kalous J, Kubelka M, Solc P, Susor A, Motlik J. AKT (protein kinase B) is implicated in meiotic maturation of porcine oocytes. Reproduction. 2009;138:645-54 pubmed publisher
  14. Yellaturu C, Deng X, Cagen L, Wilcox H, Mansbach C, Siddiqi S, et al. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. J Biol Chem. 2009;284:7518-32 pubmed publisher
  15. Sundstrom J, Sundstrom C, Sundstrom S, Fort P, Rauscher R, Gardner T, et al. Phosphorylation site mapping of endogenous proteins: a combined MS and bioinformatics approach. J Proteome Res. 2009;8:798-807 pubmed publisher
  16. Chu C, Tzang B, Chen L, Liu C, Tsai F, Tsai C, et al. Activation of insulin-like growth factor II receptor induces mitochondrial-dependent apoptosis through G(alpha)q and downstream calcineurin signaling in myocardial cells. Endocrinology. 2009;150:2723-31 pubmed publisher
  17. Cohen-Kaplan V, Doweck I, Naroditsky I, Vlodavsky I, Ilan N. Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res. 2008;68:10077-85 pubmed
  18. Hayata K, Sakano K, Nishinaka S. Establishment of new highly insulin-sensitive cell lines and screening of compounds to facilitate glucose consumption. J Pharmacol Sci. 2008;108:348-54 pubmed
  19. Palozza P, Sestito R, Picci N, Lanza P, Monego G, Ranelletti F. The sensitivity to beta-carotene growth-inhibitory and proapoptotic effects is regulated by caveolin-1 expression in human colon and prostate cancer cells. Carcinogenesis. 2008;29:2153-61 pubmed publisher
  20. Guo W, Zeng M, Yadav A, Song L, Guo B, Band V, et al. Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res. 2007;67:5083-9 pubmed
  21. Eidenschenk C, Jouanguy E, Alcais A, Mention J, Pasquier B, Fleckenstein I, et al. Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes. J Immunol. 2006;177:8835-43 pubmed
  22. Malmlöf M, Roudier E, Hogberg J, Stenius U. MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signaling. J Biol Chem. 2007;282:2288-96 pubmed
  23. Redondo-Muñoz J, Escobar-Díaz E, Samaniego R, Terol M, García-Marco J, Garcia-Pardo A. MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration. Blood. 2006;108:3143-51 pubmed
  24. Kim C, Vasko V, Kato Y, Kruhlak M, Saji M, Cheng S, et al. AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma. Endocrinology. 2005;146:4456-63 pubmed
  25. Kalous J, Solc P, Baran V, Kubelka M, Schultz R, Motlik J. PKB/AKT is involved in resumption of meiosis in mouse oocytes. Biol Cell. 2006;98:111-23 pubmed
  26. Gingis-Velitski S, Zetser A, Flugelman M, Vlodavsky I, Ilan N. Heparanase induces endothelial cell migration via protein kinase B/Akt activation. J Biol Chem. 2004;279:23536-41 pubmed
  27. Zetser A, Bashenko Y, Miao H, Vlodavsky I, Ilan N. Heparanase affects adhesive and tumorigenic potential of human glioma cells. Cancer Res. 2003;63:7733-41 pubmed
  28. Clark R, Miskimins W, Miskimins R. Phosphatidylinositol-3 kinase p85 enhances expression from the myelin basic protein promoter in oligodendrocytes. J Neurochem. 2002;83:565-73 pubmed
  29. Yellaturu C, Bhanoori M, Neeli I, Rao G. N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A. J Biol Chem. 2002;277:40148-55 pubmed
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
www.scbt.com
1.800.457.3801
headquarters: USA