product summary
request information :
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
Akt1 (B-1) Antibody
catalog :
sc-5298
quantity :
200 µg/ml
price :
279 USD
clonality :
monoclonal
host :
mouse
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation, flow cytometry
publications citing this reagent :
total: 46
  1. rat (western blot(1:500))
    Salvatierra C, Reis S, Pessoa A, Souza L, Stoppiglia L, Veloso R, et al. Short-term low-protein diet during pregnancy alters islet area and protein content of phosphatidylinositol 3-kinase pathway in rats. An Acad Bras Cienc. 2015;87:1007-1018 pubmed
  2. mouse (western blot(1:1000))
    Marathe S, Liu S, Brai E, Kaczarowski M, Alberi L. Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry. Cell Death Differ. 2015;: pubmed publisher
  3. human (western blot)
    Shen Y, Gao M, Ma Y, Yu H, Cui F, Gregersen H, et al. Effect of surface chemistry on the integrin induced pathway in regulating vascular endothelial cells migration. Colloids Surf B Biointerfaces. 2015;126:188-97 pubmed publisher
  4. human (western blot(1:1000))
    Chavali P, Saini R, Zhai Q, Vizlin-Hodzic D, Venkatabalasubramanian S, Hayashi A, et al. TLX activates MMP-2, promotes self-renewal of tumor spheres in neuroblastoma and correlates with poor patient survival. Cell Death Dis. 2014;5:e1502 pubmed publisher
  5. human (western blot)
    Bailon E, Ugarte-Berzal E, Amigo-Jiménez I, Van den Steen P, Opdenakker G, García-Marco J, et al. Overexpression of progelatinase B/proMMP-9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen. J Leukoc Biol. 2014;96:185-99 pubmed publisher
  6. human (western blot : immunoprecipitation)
    Choi Y, Kim Y, Jeong H, Jin Y, Yeo C, Lee K. Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation. FEBS J. 2014;281:3656-66 pubmed publisher
  7. human (western blot(1:1000))
    Tanaka T, Iino M. Sec6 regulated cytoplasmic translocation and degradation of p27 via interactions with Jab1 and Siah1. Cell Signal. 2014;26:2071-85 pubmed publisher
  8. human (western blot)
    Subramani R, Lopez-Valdez R, Arumugam A, Nandy S, Boopalan T, Lakshmanaswamy R. Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis. PLoS ONE. 2014;9:e97016 pubmed publisher
  9. human (western blot)
    Liu X, Chen L, Feng B, Liu G. Reversing effect of sorcin in the drug resistance of human nasopharyngeal carcinoma. Anat Rec (Hoboken). 2014;297:215-21 pubmed publisher
  10. human (western blot(1:1000))
    Tanaka T, Iino M. Knockdown of Sec8 promotes cell-cycle arrest at G1/S phase by inducing p21 via control of FOXO proteins. FEBS J. 2014;281:1068-84 pubmed publisher
product information
product name :
Akt1 (B-1) Antibody
gene name :
AKT1, AKT2, AKT3
size :
200 µg/ml
price :
279 USD
catalog number :
sc-5298
type :
Monoclonal
host :
mouse monoclonal
antigen :
Akt1
reactive species  :
m, r, h
applications :
WB, IP, IF, FCM, ELISA
epitope :
345-480 (h)
delivery :
Next day delivery in US for orders placed by 3:00 PM; Two day delivery for orders shipped internationally from our US office; Next day delivery to European customers placing orders from our European office
publications citing this reagent :
  1. human (western blot(1:500))
    Qi L, Zhang Y. Truncation of inhibitor of growth family protein 5 effectively induces senescence, but not apoptosis in human tongue squamous cell carcinoma cell line. Tumour Biol. 2014;35:3139-44 pubmed publisher
  2. Liu N, Xi Y, Callaghan M, Fribley A, Moore-Smith L, Zimmerman J, et al. SMAD4 is a potential prognostic marker in human breast carcinomas. Tumour Biol. 2014;35:641-50 pubmed publisher
  3. Fekete A, B Gel G, Pesti S, Péterfi Z, Geiszt M, Buday L. EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5. J Mol Signal. 2013;8:8 pubmed
  4. Bogazzi F, Raggi F, Russo D, Bohlooly-Y M, Sardella C, Urbani C, et al. Growth hormone is necessary for the p53-mediated, obesity-induced insulin resistance in male C57BL/6J x CBA mice. Endocrinology. 2013;154:4226-36 pubmed publisher
  5. Yang Y, Li X, Wang L, Han S, Zhang Y, Pratheeshkumar P, et al. Anti-apoptotic proteins and catalase-dependent apoptosis resistance in nickel chloride-transformed human lung epithelial cells. Int J Oncol. 2013;43:936-46 pubmed publisher
  6. Son Y, Pratheeshkumar P, Wang L, Wang X, Fan J, Kim D, et al. Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling. Toxicol Appl Pharmacol. 2013;271:239-48 pubmed publisher
  7. Murugan A, Alzahrani A, Xing M. Mutations in critical domains confer the human mTOR gene strong tumorigenicity. J Biol Chem. 2013;288:6511-21 pubmed publisher
  8. Cai N, Wang Y, Zheng P. The microRNA-302-367 cluster suppresses the proliferation of cervical carcinoma cells through the novel target AKT1. RNA. 2013;19:85-95 pubmed publisher
  9. Blich M, Golan A, Arvatz G, Sebbag A, Shafat I, Sabo E, et al. Macrophage activation by heparanase is mediated by TLR-2 and TLR-4 and associates with plaque progression. Arterioscler Thromb Vasc Biol. 2013;33:e56-65 pubmed publisher
  10. Booher K, Lin D, Borrego S, Kaiser P. Downregulation of Cdc6 and pre-replication complexes in response to methionine stress in breast cancer cells. Cell Cycle. 2012;11:4414-23 pubmed publisher
  11. Son Y, Wang L, Poyil P, Budhraja A, Hitron J, Zhang Z, et al. Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling. Toxicol Appl Pharmacol. 2012;264:153-60 pubmed publisher
  12. Song S, Lee M, Lee J, Jeong H, Kim H, Kim W, et al. Genetic modification of human adipose-derived stem cells for promoting wound healing. J Dermatol Sci. 2012;66:98-107 pubmed publisher
  13. Hung S, Chiang H, Wu C, Hsu M, Chen Y. Effects of herpes simplex virus type 1 infection on immune functions of human neutrophils. J Periodontal Res. 2012;47:635-44 pubmed publisher
  14. Ali I, Damdimopoulou P, Stenius U, Adamsson A, Mäkelä S, Akesson A, et al. Cadmium-induced effects on cellular signaling pathways in the liver of transgenic estrogen reporter mice. Toxicol Sci. 2012;127:66-75 pubmed publisher
  15. Cohen-Kaplan V, Jrbashyan J, Yanir Y, Naroditsky I, Ben-Izhak O, Ilan N, et al. Heparanase induces signal transducer and activator of transcription (STAT) protein phosphorylation: preclinical and clinical significance in head and neck cancer. J Biol Chem. 2012;287:6668-78 pubmed publisher
  16. Nagel J, Brinkoetter M, Magkos F, Liu X, Chamberland J, Shah S, et al. Dietary walnuts inhibit colorectal cancer growth in mice by suppressing angiogenesis. Nutrition. 2012;28:67-75 pubmed publisher
  17. Lin W, Rahman N, Lin J, Zhang H, Gou K, Yu W, et al. Molecular mechanisms of bladder outlet obstruction in transgenic male mice overexpressing aromatase (Cyp19a1). Am J Pathol. 2011;178:1233-44 pubmed publisher
  18. Zhang L, Sun S, Zhou J, Liu J, Lv J, Yu X, et al. Knockdown of Akt1 promotes Akt2 upregulation and resistance to oxidative-stress-induced apoptosis through control of multiple signaling pathways. Antioxid Redox Signal. 2011;15:1-17 pubmed publisher
  19. Mukherjee A, Badal Y, Nguyen X, Miller J, Chenna A, Tahir H, et al. Profiling the HER3/PI3K pathway in breast tumors using proximity-directed assays identifies correlations between protein complexes and phosphoproteins. PLoS ONE. 2011;6:e16443 pubmed publisher
  20. Leksa V, Loewe R, Binder B, Schiller H, Eckerstorfer P, Forster F, et al. Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation. Circ Res. 2011;108:676-85 pubmed publisher
  21. Motegi H, Shimo Y, Akiyama T, Inoue J. TRAF6 negatively regulates the Jak1-Erk pathway in interleukin-2 signaling. Genes Cells. 2011;16:179-89 pubmed publisher
  22. Zhang W, Lee J, Kim I, Kim Y, Park J, Myung C. 7-O-methylaromadendrin stimulates glucose uptake and improves insulin resistance in vitro. Biol Pharm Bull. 2010;33:1494-9 pubmed
  23. Voutsadakis I, Patrikidou A, Tsapakidis K, Karagiannaki A, Hatzidaki E, Stathakis N, et al. Additive inhibition of colorectal cancer cell lines by aspirin and bortezomib. Int J Colorectal Dis. 2010;25:795-804 pubmed publisher
  24. Kalous J, Kubelka M, Solc P, Susor A, Motlik J. AKT (protein kinase B) is implicated in meiotic maturation of porcine oocytes. Reproduction. 2009;138:645-54 pubmed publisher
  25. Yellaturu C, Deng X, Cagen L, Wilcox H, Mansbach C, Siddiqi S, et al. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association with COPII vesicles. J Biol Chem. 2009;284:7518-32 pubmed publisher
  26. Sundstrom J, Sundstrom C, Sundstrom S, Fort P, Rauscher R, Gardner T, et al. Phosphorylation site mapping of endogenous proteins: a combined MS and bioinformatics approach. J Proteome Res. 2009;8:798-807 pubmed publisher
  27. Chu C, Tzang B, Chen L, Liu C, Tsai F, Tsai C, et al. Activation of insulin-like growth factor II receptor induces mitochondrial-dependent apoptosis through G(alpha)q and downstream calcineurin signaling in myocardial cells. Endocrinology. 2009;150:2723-31 pubmed publisher
  28. Cohen-Kaplan V, Doweck I, Naroditsky I, Vlodavsky I, Ilan N. Heparanase augments epidermal growth factor receptor phosphorylation: correlation with head and neck tumor progression. Cancer Res. 2008;68:10077-85 pubmed publisher
  29. Hayata K, Sakano K, Nishinaka S. Establishment of new highly insulin-sensitive cell lines and screening of compounds to facilitate glucose consumption. J Pharmacol Sci. 2008;108:348-54 pubmed
  30. Palozza P, Sestito R, Picci N, Lanza P, Monego G, Ranelletti F. The sensitivity to beta-carotene growth-inhibitory and proapoptotic effects is regulated by caveolin-1 expression in human colon and prostate cancer cells. Carcinogenesis. 2008;29:2153-61 pubmed publisher
  31. Guo W, Zeng M, Yadav A, Song L, Guo B, Band V, et al. Mel-18 acts as a tumor suppressor by repressing Bmi-1 expression and down-regulating Akt activity in breast cancer cells. Cancer Res. 2007;67:5083-9 pubmed
  32. Eidenschenk C, Jouanguy E, Alcais A, Mention J, Pasquier B, Fleckenstein I, et al. Familial NK cell deficiency associated with impaired IL-2- and IL-15-dependent survival of lymphocytes. J Immunol. 2006;177:8835-43 pubmed
  33. Malmlöf M, Roudier E, Hogberg J, Stenius U. MEK-ERK-mediated phosphorylation of Mdm2 at Ser-166 in hepatocytes. Mdm2 is activated in response to inhibited Akt signaling. J Biol Chem. 2007;282:2288-96 pubmed
  34. Redondo-Muñoz J, Escobar-Díaz E, Samaniego R, Terol M, García-Marco J, Garcia-Pardo A. MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration. Blood. 2006;108:3143-51 pubmed
  35. Kim C, Vasko V, Kato Y, Kruhlak M, Saji M, Cheng S, et al. AKT activation promotes metastasis in a mouse model of follicular thyroid carcinoma. Endocrinology. 2005;146:4456-63 pubmed
  36. Kalous J, Solc P, Baran V, Kubelka M, Schultz R, Motlik J. PKB/AKT is involved in resumption of meiosis in mouse oocytes. Biol Cell. 2006;98:111-23 pubmed
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
www.scbt.com
1.800.457.3801
headquarters: USA