This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Santa Cruz Biotechnology
product type :
antibody
product name :
p16 (C-20)
catalog :
sc-468
conjugate :
nonconjugated
reactivity :
human, mouse, dog
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other, western blot knockout validation
citations: 28
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:500; loading ...; fig s1a
Nakagawa N, Li J, Yabuno Nakagawa K, Eom T, Cowles M, Mapp T, et al. APC sets the Wnt tone necessary for cerebral cortical progenitor development. Genes Dev. 2017;31:1679-1692 pubmed publisher
  • immunocytochemistry; human; fig 1a
Rahman M, Hazan A, Selway J, Herath D, Harwood C, Pirzado M, et al. A Novel Mechanism for Activation of GLI1 by Nuclear SMO That Escapes Anti-SMO Inhibitors. Cancer Res. 2018;78:2577-2588 pubmed publisher
  • immunoprecipitation; mouse; 1:500-1:1000; fig 2e
  • western blot; mouse; 1:500-1:1000; fig 2e
  • immunoprecipitation; human; 1:500-1:1000; loading ...; fig 2c
  • western blot; human; 1:500-1:1000; loading ...; fig 2c
Chen Z, Donnelly C, Dominguez B, Harada Y, Lin W, Halim A, et al. p75 Is Required for the Establishment of Postnatal Sensory Neuron Diversity by Potentiating Ret Signaling. Cell Rep. 2017;21:707-720 pubmed publisher
  • western blot; human; loading ...; fig 5b
Al Khalaf H, Amir M, Al Mohanna F, Tulbah A, Al Sayed A, Aboussekhra A. Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity. Mol Cell Biol. 2017;37: pubmed publisher
  • immunohistochemistry; human; loading ...; fig 10
Garcia Hernandez M, Uribe Uribe N, Espinosa González R, Kast W, Khader S, Rangel Moreno J. A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression. Front Immunol. 2017;8:563 pubmed publisher
  • immunoprecipitation; human; loading ...; fig EV2a
Lafont E, Kantari Mimoun C, Dráber P, De Miguel D, Hartwig T, Reichert M, et al. The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death. EMBO J. 2017;36:1147-1166 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 5h
Iurlaro R, Püschel F, León Annicchiarico C, O Connor H, Martin S, Palou Gramón D, et al. Glucose Deprivation Induces ATF4-Mediated Apoptosis through TRAIL Death Receptors. Mol Cell Biol. 2017;37: pubmed publisher
  • western blot; human; loading ...; fig 2b
Gribling Burrer A, Leichter M, Wurth L, Huttin A, Schlotter F, Troffer Charlier N, et al. SECIS-binding protein 2 interacts with the SMN complex and the methylosome for selenoprotein mRNP assembly and translation. Nucleic Acids Res. 2017;45:5399-5413 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 2
Bizzarro V, Belvedere R, Migliaro V, Romano E, Parente L, Petrella A. Hypoxia regulates ANXA1 expression to support prostate cancer cell invasion and aggressiveness. Cell Adh Migr. 2017;11:247-260 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 6b
Pamarthy S, Mao L, Katara G, Fleetwood S, Kulshreshta A, Gilman Sachs A, et al. The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling. Cell Death Dis. 2016;7:e2443 pubmed publisher
  • flow cytometry; human; loading ...; fig s2a
Chen D, Ireland S, Remington G, Alvarez E, Racke M, Greenberg B, et al. CD40-Mediated NF-?B Activation in B Cells Is Increased in Multiple Sclerosis and Modulated by Therapeutics. J Immunol. 2016;197:4257-4265 pubmed
  • immunohistochemistry; human; loading ...; fig 5b
  • western blot; human; loading ...; fig 5a
Wu S, Pan S, Zhang L, Baines J, Roller R, Ames J, et al. Herpes Simplex Virus 1 Induces Phosphorylation and Reorganization of Lamin A/C through the ?134.5 Protein That Facilitates Nuclear Egress. J Virol. 2016;90:10414-10422 pubmed
  • immunocytochemistry; mouse; 1:2000; loading ...; fig 2h
  • western blot; human; 1:2000; fig 7d
Luo W, Li S, Li C, Lian H, Yang Q, Zhong B, et al. iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING. Nat Immunol. 2016;17:1057-66 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig 7d
  • western blot; mouse; loading ...; fig 7d
Jin J, Valanejad L, Nguyen T, Lewis K, Wright M, Cast A, et al. Activation of CDK4 Triggers Development of Non-alcoholic Fatty Liver Disease. Cell Rep. 2016;16:744-56 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 2d
  • western blot; human; loading ...; fig 2d
Chakedis J, French R, Babicky M, Jaquish D, Mose E, Cheng P, et al. Characterization of RON protein isoforms in pancreatic cancer: implications for biology and therapeutics. Oncotarget. 2016;7:45959-45975 pubmed publisher
  • western blot; human; loading ...; fig 6d
  • western blot; dog; loading ...; fig 1b
Chen C, Wang S, Chan P, Shen M, Chen H. Phosphorylation of E-cadherin at threonine 790 by protein kinase C? reduces ?-catenin binding and suppresses the function of E-cadherin. Oncotarget. 2016;7:37260-37276 pubmed publisher
  • western blot; human; 1:750; loading ...; fig 1b
Coleman D, Gray A, Kridel S, Cardelli J. Palmitoylation regulates the intracellular trafficking and stability of c-Met. Oncotarget. 2016;7:32664-77 pubmed publisher
  • western blot; human; fig 3g
Muramatsu T, Kozaki K, Imoto S, Yamaguchi R, Tsuda H, Kawano T, et al. The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma. Oncogene. 2016;35:5304-5316 pubmed publisher
  • western blot; mouse; loading ...; fig 1g
Lakshmipathi J, Alvarez Perez J, Rosselot C, Casinelli G, Stamateris R, Rausell Palamos F, et al. PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2. Diabetes. 2016;65:1283-96 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 6e
  • western blot; human; loading ...; fig 6b
Keka I, Mohiuddin -, Maede Y, Rahman M, Sakuma T, Honma M, et al. Smarcal1 promotes double-strand-break repair by nonhomologous end-joining. Nucleic Acids Res. 2015;43:6359-72 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 1
Bian C, Li Z, Xu Y, Wang J, Xu L, Shen H. Clinical outcome and expression of mutant P53, P16, and Smad4 in lung adenocarcinoma: a prospective study. World J Surg Oncol. 2015;13:128 pubmed publisher
  • western blot; human; loading ...; fig 2b
Kim Y, Ahn J. Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus. PLoS Pathog. 2015;11:e1004785 pubmed publisher
  • western blot; mouse; loading ...; fig 8
Rothaug M, Stroobants S, Schweizer M, Peters J, Zunke F, Allerding M, et al. LAMP-2 deficiency leads to hippocampal dysfunction but normal clearance of neuronal substrates of chaperone-mediated autophagy in a mouse model for Danon disease. Acta Neuropathol Commun. 2015;3:6 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3c
Delgado Olguín P, Dang L, He D, Thomas S, Chi L, Sukonnik T, et al. Ezh2-mediated repression of a transcriptional pathway upstream of Mmp9 maintains integrity of the developing vasculature. Development. 2014;141:4610-7 pubmed publisher
  • western blot; human; loading ...; fig 3a
Le Saout C, Hasley R, Imamichi H, Tcheung L, Hu Z, Luckey M, et al. Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis. PLoS Pathog. 2014;10:e1003976 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig 1a
  • western blot; mouse; 1:1000; loading ...; fig 1a
Calco G, Stephens O, Donahue L, Tsui C, Pierchala B. CD2-associated protein (CD2AP) enhances casitas B lineage lymphoma-3/c (Cbl-3/c)-mediated Ret isoform-specific ubiquitination and degradation via its amino-terminal Src homology 3 domains. J Biol Chem. 2014;289:7307-19 pubmed publisher
Xiong Z, Choi J, Wang K, Zhang H, Tariq Z, Wu D, et al. Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. Aging Cell. 2016;15:279-90 pubmed publisher
company information
Santa Cruz Biotechnology
2145 Delaware Avenue
Santa Cruz, CA 95060
scbt@scbt.com
www.scbt.com
1.800.457.3801
headquarters: USA