product summary
request information :
company name :
ProMab
product type :
antibody
product name :
Mouse Monoclonal Antibody to ER
catalog :
20139
quantity :
100µl
price :
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
western blot, ELISA
more info or order :
product information
Catalog :
20139
Title :
Mouse Monoclonal Antibody to ER
Species :
Human
Clone :
5D4B1;
lsotype :
Mouse IgG2b
Size :
100µl
Storage :
4?; -20? for long term storage
Description :
ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites. Serines 104, 106, 118 and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serines plays an important role in regulating ER activity. Ser118 may be the substrate of the transcription regulatory kinase cdK7. Ser167 may be phosphorylated by p90RSK and Akt. Phosphorylation of Ser167 may confer tamoxifen resistance in breast cancer patients.
Immunogen :
Purified recombinant fragment of ER expressed in E. Coli.
Formulation :
Ascitic fluid containing 0.03% sodium azide.
Applications :
ELISA: 1/10000; WB: 1/500 - 1/2000
References :
1. ampbell, R.A. et al. 2001, J. Biol. Chem. 276, 9817-9824. ; 2. Chen, D. et al. 2000, Mol. Cell 6, 127-137. ;
Price :
$240
Type :
Monoclonal Antibody
Aliases :
ER; ESR; Era; ESRA; NR3A1; DKFZp686N23123; ESR1
EG :
2099
more info or order :
company information
ProMab
5221 Central Avenue, Suite 200
Richmond, CA 94804
info@promab.com
www.promab.com
1-866-339-0871
headquarters: USA