product summary
request information :
company name :
ProMab
product type :
antibody
product name :
Mouse Monoclonal Antibody to ER-alpha
catalog :
20047
quantity :
100µl
price :
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
western blot, ELISA, immunohistochemistry
more info or order :
product information
Catalog :
20047
Title :
Mouse Monoclonal Antibody to ER-alpha
Species :
Human
Clone :
2B7;
lsotype :
Mouse IgG1
Size :
100µl
Storage :
4?; -20? for long term storage
Description :
The estrogen receptor (ER) is a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. Alternative splicing results in several ER mRNA transcripts, which differ primarily in their 5-prime untranslated regions. Two isoforms of the human ER, ERA and ER-beta, occur, each with distinct tissue and cell patterns of expression. Pelletier and El-Alfy (2000) studied the immunocytochemical localization of ESRA and ESRB in human reproductive tissues. In the ovary, ERB immunoreactivity was found in nuclei of granulosa cells of growing follicles at all stages from primary to mature follicles, interstitial gland, and germinal epithelium cells. Nuclear staining for ERA occurred in thecal, interstitial gland, and germinal epithelium cells. In the uterus, strong ERA immunoreactivity was detected in nuclei of epithelial, stromal, and muscle cells.
Immunogen :
Purified recombinant fragment of human ER-alpha (410-592aa) expressed in E. Coli.
Formulation :
Purified antibody in PBS containing 0.03% sodium azide.
Applications :
ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000
References :
1. Paech K. Science 1997, 277: 1508- 10. ; 2. Pertschuk LP,Cancer, 1996. 199677: 514- 9. ;
Price :
$180
Type :
Monoclonal Antibody
Aliases :
ER; ESR1; Era; ESRA
EG :
2099
more info or order :
company information
ProMab
5221 Central Avenue, Suite 200
Richmond, CA 94804
info@promab.com
www.promab.com
1-866-339-0871
headquarters: USA