This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Mouse Monoclonal FACA/FANCA Antibody
catalog :
NBP1-18973
quantity :
0.1 ml
price :
299.00 USD
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
western blot, immunoprecipitation
citations: 4
Zhu B, Yan K, Li L, Lin M, Zhang S, He Q, et al. K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks. Oncogene. 2015;34:2867-78 pubmed publisher
Waisfisz Q, de Winter J, Kruyt F, de Groot J, van Der Weel L, Dijkmans L, et al. A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA. Proc Natl Acad Sci U S A. 1999;96:10320-5 pubmed
de Winter J, van Der Weel L, de Groot J, Stone S, Waisfisz Q, Arwert F, et al. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. Hum Mol Genet. 2000;9:2665-74 pubmed
Meetei A, Sechi S, Wallisch M, Yang D, Young M, Joenje H, et al. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol Cell Biol. 2003;23:3417-26 pubmed
product information
Catalog Number :
NBP1-18973
Product Name :
Mouse Monoclonal FACA/FANCA Antibody
List Price :
299.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
FA, FA1, FAAMGC75158, FACAFanconi anemia group A protein, FAH, FA-H, FANCH, Fanconi anemia, complementation group A, Fanconi anemia, complementation group H, Fanconi anemia, type 1, Protein FACA
Background :
FANCA (Faconi Anemia Group A Protein) is a DNA repair protein. It may function as a cell cycle checkpoint or in post replication repair. FANCA may be important for the maintenance of chromosome stability and reparation of interstrand DNA cross linkages. Defects in this protein result in a disease state, Fanconi anemia, an autosomal recessive disorder. Fanconi anemia results in may congenital malformations and predisposition to malignant formations.
Buffer :
PBS
Clonality :
Monoclonal
Clone :
5G9
Concentration :
2 mg/ml
Application Summary :
Western Blot, Immunoprecipitation
Host :
Mouse
Immunogen :
A synthetic peptide made to a C-terminal region of human FANCA (within amino acids 1380-1455) [Swiss-Prot #O15360].
Isotype :
IgG1
Localization :
Nucleus. Cytoplasm. Note= The major form is nuclear. The minor form is cytoplasmic.
Preservative :
No Preservative
Purity :
Protein G purified
CrossReactivity :
Human
Storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Swissprot Human :
O15360
TMW :
163 kDa
Uses :
This FANCA antibody is useful for Immunoprecipitation and Western Blot, where a band is seen ~163 kDa.
Research Area :
Cancer, DNA Repair, Genes Sensitive to DNA Damaging Agents
References Product :
Zhu B, Yan K, Li L et al. K63-linked ubiquitination of FANCG is required for its association with the Rap80-BRCA1 complex to modulate homologous recombination repair of DNA interstand crosslinks. Oncogene. 2014 Aug 18 [PMID: 25132264] Meetei, AR et al. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome. Mol Cell Biol;23(10):3417-26. 2003 May. [PMID: 12724401] (IP, WB, Human) de Winter, JP et al. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. Hum Mol Genet;9(18):2665-74. 2000 Nov 1. [PMID: 11063725] (WB, IP, Human) Waisfisz, Q et al. A physical complex of the Fanconi anemia proteins FANCG/XRCC9 and FANCA. Proc Natl Acad Sci U S A;96(18):10320-5. 1999 Aug 31. [PMID: 10468606] (IP, WB, Human)
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.