product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Mouse Monoclonal Insulin R/CD220 Antibody
catalog :
NB400-142R
quantity :
0.1 ml
price :
319 USD
clonality :
monoclonal
host :
mouse
reactivity :
mouse, rat, human
application :
ELISA, western blot, neutralization, immunoprecipitation
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB400-142R
Product Name :
Mouse Monoclonal Insulin R/CD220 Antibody
List Price :
319 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
CD 220, CD220, CD220 antigen, EC 2.7.10, EC 2.7.10.1, HHF5, insulin receptor, IR
Background :
The insulin receptor is functionally important for negative cooperativity, down-regulation, and beta-subunit tyrosine kinase activity. There are two recognized epitopes of the alpha-subunit. One epitope is close to the insulin-binding site and plays a role in insulin-induced negative cooperativity and down-regulation. The other site (recognized by the monoclonal MA-20 antibody) is at a distance from the insulin-binding site, where it only plays a role in down-regulation. Both epitopes appear to be independent of insulin receptor tyrosine kinase activity.
Buffer :
50mM sodium borate
Clonality :
Monoclonal
Clone :
MA-20
Concentration :
1.2 mg/ml
Conjugate :
DyLight 550
Application Summary :
Western Blot, Blocking/Neutralizing, ELISA, Immunoprecipitation
Host :
Mouse
Immunogen :
Highly purified Insulin Receptor (alpha-subunit) from human term placentas. [UniProt# P06213]
Isotype :
IgG2b
Localization :
Membrane; single pass type I membrane protein.
Preservative :
No Preservative
Purity :
Protein G purified
CrossReactivity :
Human and rat. Mouse reactivity reported in scientific literature (PMID: 24389353)
Storage :
Store at 4C in the dark.
Swissprot Human :
P06213
Uses :
This Insulin Receptor (MA-20) antibody is useful for ELISA, Immunoprecipitation, Western blot and Blocking/Neutralizing assays.
Research Area :
Diabetes Research, Lipid and Metabolism, Neuroscience, Nutrient Sensing in the Brain, Protein Kinase, Signal Transduction, Tyrosine Kinases
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.