product summary
request information :
company name :
Novus Biologicals
product type :
antibody
product name :
Mouse Monoclonal VEGF Receptor 1 Antibody
catalog :
NB100-527G
quantity :
0.1 mg
price :
399.00 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, rat, mouse
application :
western blot, flow cytometry
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB100-527G
Product Name :
Mouse Monoclonal VEGF Receptor 1 Antibody
List Price :
399.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 mg
AltNames :
EC 2.7.10.1, EC 2.7.10, FLT, FLT-1, Fms-like tyrosine kinase 1, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascularpermeability factor receptor), FRT, Tyrosine-protein kinase receptor FLT, Tyrosine-protein kinase FRT, Vascular permeability factor receptor, vascular endothelial growth factor receptor 1, VEGFR1, VEGFR-1
Background :
Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Concentration :
1.0 mg/ml
Conjugate :
DyLight 488
Application Summary :
Western Blot, Flow Cytometry
Host :
Rabbit
Immunogen :
A synthetic peptide made to an internal region of the mouse VEGF Receptor 1 protein (between residues 800-900) [UniProt# P35969]. There is 87% identity between the immunogen used for this production and the VEGF Receptor 2 protein.
Localization :
Type 1 membrane protein (isoform Flt1)
Marker :
Hemangioblast Marker
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human. Immunogen sequence has 100% homology to mouse and rat.
Specificity :
This antibody targets VEGFR-1 but has significant cross-reactivity with the VEGFR-2 protein.
Storage :
Store at 4C in the dark.
Uses :
This VEGF Receptor 1 antibody is useful for Western blot, where a band is seen at ~180-230 kDa (the theoretical molecular weight of mouse VEGFR1 is ~150 kDa and human VEGFR1 is ~151 kDa). The difference in MWs is likely due to glycosylation or other post translational modifications. With CSF-1R/VEGFR2 chimera transfected lysates a doublet is seen at ~150 kDa representing VEGFR-2. An unknown band is also seen at ~50 kDa. Optimal working dilutions should be determined by the investigator.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: usa
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.