antibody

NCAM-L1 (L1CAM) Antibody

MBS857663

0.1 ml

290 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, enzyme immunoassay

Antibody

NCAM-L1 (L1CAM) Antibody

NCAM-L1

neural cell adhesion molecule L1 isoform 1; Neural cell adhesion molecule L1; neural cell adhesion molecule L1; antigen identified by monoclonal antibody R1; L1 cell adhesion molecule; CD_antigen: CD171

NCAM-L1

L1CAM; L1CAM; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1; CAML1; MIC5; N-CAM-L1; NCAM-L1

L1CAM_HUMAN

Polyclonal

IgG

Rabbit

Human, Mouse, Rat

1257

This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of CD-10.

Affinity purified

1*TBS (pH7.4), 0.5%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.

Store at 4 degree C after thawing. Aliquot store at -20 degree C or -80 degree C. Avoid repeated freeze / thaw cycles.

Western Blot (WB), ELISA (EIA)

WB: 1:500

Cellular Localization: Cell membrane

Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells; Autophagy antibody

Background: Neprilysin(CD10) is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide. peptides. Neprilysin is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, immature B cells with in adult bone marrow and on cells from patients with chronic myelocytic leukemia (CML). In neurons, neprilysin is regulated by the protein nicastrin, a component of the gamma secretase complex that performs a necessary step in processing amyloid precursor protein to amyloid.

1.Malfroy B., Kuang W.-J., Seeburg P.H., Mason A.J., Schofield P.R.; "Molecular cloning and amino acid sequence of human enkephalinase (neutral endopeptidase)."; FEBS Lett. 229:206-210(1988). 2.Turner AJ, Isaac RE, Coates D, et al. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function [J]. Bioessays, 2001,23:261-269. 3.Oefner C, D'Arcy A, Hennig M, et al. Structure of Human Neutral Endopeptidase (Neprilysin) Complexed with Phosphoramidon [J]. J Mol Biol, 2000, 296:341-349.

4557707

NP_000416.1

NM_000425.4

P32004

~220kDa

Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!Axon Guidance Pathway 105688!!Basigin Interactions Pathway 106065!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480!!Cell Surface Interactions At The Vascular Wall Pathway 106062!!Developmental Biology Pathway 477129!!Hemostasis Pathway 106028!!Interaction Between L1 And Ankyrins Pathway 161005

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]

0.1 ml

290 USD