MyBioSource

antibody

ABCB5 (ATP-binding cassette, sub-family B MDR/TAP, ABCB5alpha, ABCB5beta, EST422562, ATP-binding cassette, sub-family B, member 5N: P-glycoprotein ABCB5)

MBS622538

0.1 mg

490 USD

polyclonal

goat

human

western blot, ELISA, enzyme immunoassay

MBS622538

Antibody

ABCB5 (ATP-binding cassette, sub-family B MDR/TAP, ABCB5alpha, ABCB5beta, EST422562, ATP-binding cassette, sub-family B, member 5N: P-glycoprotein ABCB5)

ABCB5

Anti -ABCB5 (ATP-binding cassette, sub-family B MDR/TAP, ABCB5alpha, ABCB5beta, EST422562, ATP-binding cassette, sub-family B, member 5N: P-glycoprotein ABCB5)

ATP-binding cassette sub-family B member 5 isoform 1; ATP-binding cassette sub-family B member 5; ATP-binding cassette sub-family B member 5; ABCB5 P-gp; OTTHUMP00000120018; OTTHUMP00000201813; OTTHUMP00000201814; OTTHUMP00000201940; P-glycoprotein ABCB5; ATP-binding cassette protein; ATP-binding cassette, sub-family B (MDR/TAP), member 5; ABCB5 P-gp; P-glycoprotein ABCB5

ABCB5; ABCB5; ABCB5beta; EST422562; ABCB5alpha; N/A

ABCB5_HUMAN

Polyclonal

Host: Goat; Source: Human

Human

Recognizes human ABCB5 at ~80kD.

Affinity Purified. Purified by affinity chromatography.

Supplied as a liquid in Tris saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA, Western Blot. Dilution: Peptide ELISA: <1:128,000. Western Blot: 0.03-0.1ug/ml. Detects a band at ~80kD in lystaes of A431.

Immunogen: Synthetic peptide corresponding to C-QTQHRNTSKKAQ, from the internal region of human ABCB5 (NP_848654.3).

Antibodies; Abs to Multi Drug Resistance (MDR)

ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. A number of distinct forms of ABCB5 have been shown to be expressed in various tissue types, including, but not limited to, melanocytes, melanoma cells, testis, mammary tissue, and retinal pigmented epithelium. ABCB5 is also indicated to be a metastatic melanoma progression marker.

255708477

NP_001157413.1

NM_001163941.1

Q2M3G0

89,832 Da

ABC Transporters Pathway 83035!!ABC Transporters Pathway 436

ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM]

Function: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Ref.1 Ref.6 Ref.7. Subcellular location: Cell membrane; Multi-pass membrane protein Ref.1. Tissue specificity: Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Also expressed in several malignant tissues. Ref.1 Ref.2. Miscellaneous: Depletion of ABCB5 by RNAi increases the sensitivity to several drugs of a subset of melanoma cells. Sequence similarities: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Contains 1 ABC transmembrane type-1 domain.Contains 2 ABC transporter domains. Caution: Was named ABCB1 by some authors. Sequence caution: The sequence AAN76500.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAQ03033.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

0.1 mg

490 USD