Rabbit Anti-Human c-Met Polyclonal Antibody | MyBioSource MBS300056 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Anti-Human c-Met Polyclonal Antibody

catalog :

MBS300056

quantity :

7 ml

price :

280 USD

clonality :

polyclonal

host :

rabbit

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS300056

products type :

Antibody

products full name :

Rabbit Anti-Human c-Met Polyclonal Antibody

products short name :

c-Met

other names :

hepatocyte growth factor receptor isoform b; Hepatocyte growth factor receptor; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; met proto-oncogene tyrosine kinase; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; MET proto-oncogene, receptor tyrosine kinase; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met

products gene name :

c-Met

other gene names :

MET; MET; HGFR; AUTS9; RCCP2; c-Met; HGF receptor; SF receptor

uniprot entry name :

MET_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

1390

form :

7.0 ml pre-diluted immunogen affinity purified rabbit polyclonal antibody in TBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

storage stability :

Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.

tested application :

Immunohistochemistry (IHC) Paraffin

app notes :

Immunohistochemistry Procedure . Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:50. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min. Primary Antibody Incubation: Incubate for 10 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system. Immunohistochemistry Dilution: Ready To Use. IHC Positive Control: Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma

other info2 :

Immunogen: Synthetic peptide from C-terminus of human c-Met protein. Control Tissue: Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma. Cellular Localization: Cytoplasm, Membrane. Entrez Gene Code: 4233. Pathway: Oncogenesis

products description :

The c-Met oncogene was originally isolated from a chemical carcinogen-treated human osteogenic sarcoma cell line by transfection analysis in NIH/3T3 cells. The Met proto-oncogene product was identified as a trans-membrane receptor-like protein with tyrosine kinase activity that is expressed in many tissues. The c-Met gene product has been identified as the cell surface receptor for hepatocyte growth factor, a plasminogen-like protein thought to be a humoral mediator of liver regeneration.

ncbi gi num :

42741655

ncbi acc num :

NP_000236.2

ncbi gb acc num :

NM_000245.2

ncbi mol weight :

145 kDa

ncbi pathways :

Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Arf6 Signaling Events Pathway 138034!!Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!Axon Guidance Pathway 105688!!Bacterial Invasion Of Epithelial Cells Pathway 149807!!Bacterial Invasion Of Epithelial Cells Pathway 148661!!Central Carbon Metabolism In Cancer Pathway 1059538

ncbi summary :

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

size :

7 ml

price :

280 USD