Rabbit Polyclonal to Human LAMP2 / CD107b | MyBioSource MBS240338 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human LAMP2 / CD107b

catalog :

MBS240338

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry

product information

catalog number :

MBS240338

products type :

Antibody

products full name :

Rabbit Polyclonal to Human LAMP2 / CD107b

products short name :

LAMP2 / CD107b

products name syn :

Anti-LAMP2 / CD107b Antibody (Internal) IHC-plus; LAMP2; CD107b; CD107b antigen; LAMPB; LGP110; LAMP-2; Human LAMP2; CD107b

other names :

lysosome-associated membrane glycoprotein 2 isoform B; Lysosome-associated membrane glycoprotein 2; lysosome-associated membrane glycoprotein 2; CD107 antigen-like family member B; lysosomal-associated membrane protein 2; CD107 antigen-like family member B; CD_antigen: CD107b

products gene name :

LAMP2

products gene name syn :

CD107b

other gene names :

LAMP2; LAMP2; LAMPB; CD107b; LAMP-2; LGP110; LAMP-2; Lysosome-associated membrane protein 2

uniprot entry name :

LAMP2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

410

specificity :

17 amino acid peptide from near the center of human LAMP-2

purity :

Immunoaffinity Purified

form :

PBS, 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

tested application :

Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)

app notes :

ICC (7.5 - 10 ug/ml), IHC-P (5 ug/ml), WB (1 - 2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human LAMP2.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: LAMP2 / CD107b antibody was raised against synthetic peptide from human LAMP2. Antigen Modification: Internal

products categories :

Family: Cancer

products description :

Lysosomal-Associated Membrane Protein 2 (LAMP2) is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. LAMP2 may play a role in tumor cell metastasis. LAMP2 may also function in the protection, maintenance, and adhesion of the lysosome.

ncbi gi num :

7669503

ncbi acc num :

NP_054701.1

ncbi gb acc num :

NM_013995.2

uniprot acc num :

P13473

ncbi mol weight :

45,170 Da

ncbi pathways :

Hemostasis Pathway (106028); Lysosome Pathway (99052); Lysosome Pathway (96865); Phagosome Pathway (153910); Phagosome Pathway (153859); Platelet Activation, Signaling And Aggregation Pathway (106034); Platelet Degranulation Pathway (106050); Response To Elevated Platelet Cytosolic Ca2+ Pathway (106048); Senescence And Autophagy Pathway (198780); Tuberculosis Pathway (213780)

ncbi summary :

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008]

uniprot summary :

LAMP2: Implicated in tumor cell metastasis. May function in protection of the lysosomal membrane from autodigestion, maintenance of the acidic environment of the lysosome, adhesion when expressed on the cell surface (plasma membrane), and inter- and intracellular signal transduction. Protects cells from the toxic effects of methylating mutagens. Defects in LAMP2 are the cause of Danon disease (DAND); also known as glycogen storage disease type 2B (GSD2B). DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes. Belongs to the LAMP family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: Xq24. Cellular Component: phagocytic vesicle membrane; membrane; lysosomal membrane; late endosome membrane; lysosome; late endosome; integral to membrane; plasma membrane; platelet dense granule membrane. Molecular Function: protein domain specific binding; enzyme binding. Biological Process: platelet activation; platelet degranulation; protein stabilization; blood coagulation. Disease: Danon Disease

size1 :

0.05 mg

price1 :

495 USD