Anti-Integrin alpha V antibody | MyBioSource MBS175441 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Integrin alpha V antibody

catalog :

MBS175441

quantity :

0.1 mg

price :

245 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS175441

products type :

Antibody

products full name :

Anti-Integrin alpha V antibody

products short name :

Integrin alpha V

products name syn :

Integrin alpha-V; integrin, alpha V; antigen identified by monoclonal antibody L230 antibody; CD 51 antibody; CD51 antibody; CD51 antigen antibody; DKFZp686A08142 antibody; HGNC antibody; integrin alpha V beta 3 antibody; integrin alpha-V antibody; Integrin alpha-V light chain antibody; integrin alphaVbeta3 antibody; integrin, alpha V(vitronectin receptor, alpha polypeptide, antigen CD51) antibody; ITAV_HUMAN antibody; ITGA V antibody; ITGAV antibody; Msk 8 antibody; Msk8 antibody; Vitronectin receptor alpha polypeptide antibody; Vitronectin receptor alpha polypeptide antigen CD51 antibody; Vitronectin receptor subunit alpha antibody; VNRA antibody; VTNR antibody

other names :

Integrin alpha-V; Integrin alpha-V; integrin alpha-V; integrin alphaVbeta3; vitronectin receptor subunit alpha; antigen identified by monoclonal antibody L230; integrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51); integrin, alpha V; Vitronectin receptor subunit alpha; CD_antigen: CD51Cleaved into the following 2 chains:Integrin alpha-V heavy chain; Integrin alpha-V light chain

products gene name :

ITGAV

other gene names :

ITGAV; ITGAV; CD51; MSK8; VNRA; VTNR; MSK8; VNRA

uniprot entry name :

ITAV_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

1048

purity :

Immunogen affinity purified.

form :

Lyophilized

storage stability :

At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.

tested application :

Western Blot (WB), Immunohistochemistry (IHC) Paraffin, Immunocytochemistry (ICC)

other info1 :

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha V (1028-1048aa QEEQEREQLQPHENGEGNSET), identical to the related mouse and rat sequences.

other info2 :

Contents: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

products description :

Description: Rabbit IgG polyclonal antibody for Integrin alpha-V(ITGAV) detection. Tested with WB, IHC-P, ICC in Human, Mouse, Rat. Background: Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene. It is a member of the beta 3 integrin subfamily(cytoadhesins). The human locus for the av gene(VNRA) was previously mapped to the long arm of chromosome 2. Sims et al.(2000) localized the VNRA gene to 2q31. The gene contains 30 exons and spans over 93 kb of genomic DNA. It functions as a receptor for a group of proteins that includes vitronectin, fibrinogen, thrombospondin, and von Willebrand factor.

ncbi gi num :

143811408

ncbi acc num :

P06756.2

uniprot acc num :

P06756

ncbi mol weight :

111,132 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Antigen Processing-Cross Presentation Pathway (477122); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); Cell Adhesion Molecules (CAMs) Pathway (83069); Cell Adhesion Molecules (CAMs) Pathway (480); Cell Surface Interactions At The Vascular Wall Pathway (106062); Class I MHC Mediated Antigen Processing Presentation Pathway (366161)

ncbi summary :

This gene encodes a protein that is a member of the integrin superfamily. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein undergoes post-translational cleavage to yield disulfide-linked heavy and light chains that combine with multiple integrin beta chains to form different integrins. This protein has been shown to heterodimerize with beta 1, beta 3, beta 5, beta 6, and beta 8; the heterodimer of alpha v and beta 3 is the Vitronectin receptor. This protein interacts with several extracellular matrix proteins to mediate cell adhesion and may play a role in cell migration. It is proposed that this protein may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, May 2013]

uniprot summary :

ITGAV: The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi s sarcoma lesions. Belongs to the integrin alpha chain family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion. Chromosomal Location of Human Ortholog: 2q31-q32. Cellular Component: filopodium membrane; focal adhesion; cell surface; membrane; microvillus membrane; integral to plasma membrane; plasma membrane; phagocytic vesicle; integrin complex; external side of plasma membrane. Molecular Function: viral receptor activity; voltage-gated calcium channel activity; opsonin binding; protein binding; insulin-like growth factor I binding; protein kinase C binding; protease binding; extracellular matrix binding; transforming growth factor beta binding; fibronectin binding; metal ion binding. Biological Process: negative regulation of lipid transport; axon guidance; entry of virus into host cell; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; cell-matrix adhesion; negative chemotaxis; entry of symbiont into host cell by promotion of host phagocytosis; regulation of phagocytosis; antigen processing and presentation of peptide antigen via MHC class I; positive regulation of cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; angiogenesis; cell growth; cell adhesion; integrin-mediated signaling pathway; cell migration; negative regulation of lipoprotein metabolic process; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell-substrate adhesion; heterotypic cell-cell adhesion; negative regulation of low-density lipoprotein receptor biosynthetic process; positive regulation of osteoblast proliferation; vascular endothelial growth factor receptor signaling pathway; blood coagulation; leukocyte migration; apoptotic cell clearance; positive regulation of cell migration

size1 :

0.1 mg

price1 :

245 USD