Mouse monoclonal antibody Anti-Human PCGF4 | MyBioSource MBS120256 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse monoclonal antibody Anti-Human PCGF4

catalog :

MBS120256

quantity :

0.1 mg

price :

345 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2704C2a

reactivity :

human

application :

western blot, dot blot

product information

catalog number :

MBS120256

products type :

Antibody

products full name :

Mouse monoclonal antibody Anti-Human PCGF4

products short name :

PCGF4

products name syn :

Homo sapiens BMI1 polycomb ring finger oncogene (BMI1); BMI1;RNF51; MGC12685

other names :

Homo sapiens BMI1 proto-oncogene, polycomb ring finger (BMI1), mRNA; Polycomb complex protein BMI-1; polycomb complex protein BMI-1; B lymphoma Mo-MLV insertion region 1 homolog; BMI1 polycomb ring finger oncogene; BMI1 polycomb ring finger proto-oncogene; flvi-2/bmi-1; murine leukemia viral (bmi-1) oncogene homolog; polycomb group RING finger protein 4; polycomb group protein Bmi1; ring finger protein 51; BMI1 proto-oncogene, polycomb ring finger; Polycomb group RING finger protein 4; RING finger protein 51

products gene name :

PCGF4

other gene names :

BMI1; BMI1; PCGF4; RNF51; FLVI2/BMI1

uniprot entry name :

BMI1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

2704C2a

host :

Mouse

reactivity :

Human

sequence length :

3435

concentration :

100 ug/ml (1.0 ml)

tested application :

Dot Blot (DB)

other info1 :

Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.

other info2 :

Sterility: Filtered through a 0.22 um membrane.

products description :

Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. [UniProtKB Function]

ncbi gi num :

323462179

ncbi acc num :

NP_005171.4

ncbi gb acc num :

NM_005180

ncbi mol weight :

36,949 Da

ncbi pathways :

Cellular Senescence Pathway (905991); Cellular Responses To Stress Pathway (645258); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928); Oxidative Stress Induced Senescence Pathway (905993); Senescence And Autophagy Pathway (198780); Signaling Pathways Regulating Pluripotency Of Stem Cells (1026136); Signaling Pathways Regulating Pluripotency Of Stem Cells (1033502); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]

uniprot summary :

BMI1: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119 , rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. Component of a PRC1-like complex. Interacts with RING1 and RING2. Interacts vwith CBX7 and CBX8. Interacts with SPOP. Part of a complex consisting of BMI1, CUL3 and SPOP. Interacts with E4F1. Protein type: Oncoprotein; EC 6.3.2.-; Ubiquitin conjugating system; Ligase; Motility/polarity/chemotaxis; Ubiquitin ligase. Chromosomal Location of Human Ortholog: 10p11.23. Cellular Component: nucleoplasm; nuclear body; heterochromatin; cytoplasm; PcG protein complex; nucleus; ubiquitin ligase complex. Molecular Function: protein binding; zinc ion binding; sequence-specific DNA binding; ubiquitin-protein ligase activity; chromatin binding. Biological Process: transcription, DNA-dependent; in utero embryonic development; positive regulation of immature T cell proliferation in the thymus; negative regulation of transcription from RNA polymerase II promoter; humoral immune response; embryonic skeletal morphogenesis; segment specification; rostrocaudal neural tube patterning; positive regulation of fibroblast proliferation; regulation of gene expression; positive regulation of ubiquitin-protein ligase activity; histone ubiquitination; positive regulation of B cell proliferation; DNA methylation; somatic stem cell division; hemopoiesis; histone acetylation; brain development

size1 :

0.1 mg

price1 :

345 USD