This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Anti-PELP1 Antibody (aa1000-1050) LS-C56964
catalog :
LS-C56964
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunoprecipitation
product information
AntibodyID :
57434
AntibodyName :
LS-C56964
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
Anti-PELP1 Antibody (aa1000-1050) LS-C56964
Specificity :
Recognizes MNAR (modulator of non-genomic activity of estrogen receptor), otherwise known as PELP1 (proline-, glutamic acid-, and leucine-rich protein-1), a phosphoprotein and novel steroid co-activator of the estrogen receptor (ER), which plays a role in E2-mediated cell cycle progression through interaction with the pRb pathway. MNAR acts as a transcriptional corepressor for nuclear receptors and can interact with chromatin-modifying complex components CBP (CRE-binding protein), histone deacetylase 2 and MTA (metastasis-associated protein)1. MNAR is a src SH2-binding protein which modulates the interaction of the ER to c-Src, leading to MAPK activation. Other properties of MNAR include interaction with PI3K, STAT3, and EGF, and studies have shown the deregulation of MNAR in breast tumors and endometrial cancers.
ClonalityDesc :
Polyclonal
AntibodyModification :
Unconjugated
AntigenModification :
aa1000-1050
PresentationDesc :
Tris-citrate/Phosphate buffered saline, 0.09% sodium azide.
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to an epitope within amino acid residues 1000-1050 of human MNAR (AAN41255.1).
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Gene :
PELP1
StandardGeneSymbol :
PELP1
Reactivity :
Mouse, Human
Usage :
IP, WB (1:2500 - 1:10000)
UsageText :
Western Blot: LS-C56964 detects a band of approximately 160-170kD in HeLa whole cell lysates.
Synonyms :
PELP1, MNAR, Transcription factor HMX3, p160
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
https://www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.