product summary
request information :
company name :
LifeSpan Biosciences
product type :
antibody
product name :
Anti-DLL4 Antibody (Internal) LS-C42584
catalog :
LS-C42584
clonality :
polyclonal
host :
rabbit
reactivity :
human
application :
western blot, ELISA, immunohistochemistry - paraffin section
more info or order :
LifeSpan Biosciences product webpage
product information
?AntibodyID :
42322
AntibodyName :
LS-C42584
TargetSpecies :
Human
Host Species :
Rabbit
Product Name :
Anti-DLL4 Antibody (Internal) LS-C42584
Specificity :
Detects human Delta-like ligand 4 (DLL4), also known as Delta-4. DLL4 is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the Notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn led to a decrease in tumor growth, with no apparent toxicity
ClonalityDesc :
Polyclonal
AntigenModification :
Internal
PresentationDesc :
PBS, pH 7.2, 0.09% sodium azide
ImmunogenType :
Synthetic peptide
ImmunogenDesc :
Synthetic peptide corresponding to the internal region of human DLL4.
PurificationDesc :
Affinity purified
RecommendedStorageDesc :
Long term: -20°C; Short term: +4°C. Avoid repeat freeze-thaw cycles.
IsotypeName :
IgG
Gene :
DLL4
StandardGeneSymbol :
DLL4
Reactivity :
Human
Usage :
ELISA (1:3000 - 1:15000), IHC-P (5 - 15 µg/ml), WB (1:300 - 1:1500)
UsageText :
Western Blot: LS-C42584 detects a band of approximately 74kD in pancreatic cell lysates.
Synonyms :
DLL4, Delta-like 4 protein, Delta like 4, Delta-like 4 (Drosophila), Delta-like 4 homolog, Drosophila Delta homolog 4, Notch ligand DLL4, Delta 4, Delta ligand 4, Delta-like protein 4, Delta4, Hdelta2, Notch ligand delta-2
more info or order :
LifeSpan Biosciences product webpage
company information
LifeSpan Biosciences
2401 Fourth Avenue, Suite 900
Seattle, WA 98121
antibodies@lsbio.com
www.lsbio.com
1-206-464-1554
headquarters: USA
Since 1995, LifeSpan has been the industry leader in molecular pathology, specializing in the localization of proteins in normal and diseased tissues, both human and non-human. We offer more than 74,000 antibodies, custom designed immunohistochemistry (IHC) studies, immediately available human tissue IHC profiles for more than 500 proteins, and histology and pathology services. Our bank of 2 million specimens is available to support our customers' contract research studies and contains frozen and formalin-fixed (FFPE) normal and diseased tissues. Our contract services are comprehensive; they include study design, antibody sourcing and characterization, tissue sourcing and validation, immunolabeling, trouble shooting, and interpretation of the results by a LifeSpan pathologist.