14-3-3 Pan Polyclonal Antibody | Invitrogen 51-0700 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

14-3-3 Pan Polyclonal Antibody

catalog :

51-0700

quantity :

200µg

price :

US 309.00

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow, fruit fly, platanna, Caenorhabditis elegans

application :

western blot, ELISA, immunocytochemistry

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; fruit fly; 1:200; fig 5 western blot; fruit fly; 1:1000; fig 5	Le T, Vuong L, Kim A, Hsu Y, Choi K. 14-3-3 proteins regulate Tctp-Rheb interaction for organ growth in Drosophila. Nat Commun. 2016;7:11501 pubmed publisher
western blot; mouse; fig 3	Omi K, Hachiya N, Tanaka M, Tokunaga K, Kaneko K. 14-3-3zeta is indispensable for aggregate formation of polyglutamine-expanded huntingtin protein. Neurosci Lett. 2008;431:45-50 pubmed
	Nielsen M, Luo X, Biteau B, Syverson K, Jasper H. 14-3-3 Epsilon antagonizes FoxO to control growth, apoptosis and longevity in Drosophila. Aging Cell. 2008;7:688-99 pubmed publisher
	Coblitz B, Shikano S, Wu M, Gabelli S, Cockrell L, Spieker M, et al. C-terminal recognition by 14-3-3 proteins for surface expression of membrane receptors. J Biol Chem. 2005;280:36263-72 pubmed

product information

Product Type :

Antibody

Product Name :

14-3-3 Pan Polyclonal Antibody

Catalog # :

51-0700

Quantity :

200µg

Price :

US 309.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Bovine, C. elegans, Human, Mouse, Rat, Xenopus laevis

Applications :

ELISA: 0.1-1.0 ug/ml, Immunocytochemistry: 2 µg/ml, Immunofluorescence: 2 µg/ml, Western Blot: 2 µg/ml

Species :

Bovine, C. elegans, Human, Mouse, Rat, Xenopus laevis

Isotype :

IgG

Storage :

Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C

Description :

At least seven isoforms comprise the highly conserved 14-3-3 family of homo- and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and, through interaction with Bad, prevents apoptosis. Other proteins that have been shown to bind to 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, polyoma middle-T antigen, nitrate reductase, S-raf and the IGF-1 receptor. Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases.

Immunogen :

A 20 amino acid synthetic peptide derived from the N-terminus of the human 14-3-3 beta/alpha protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.1-1.0 ug/ml, Immunocytochemistry: 2 µg/ml, Immunofluorescence: 2 µg/ml, Western Blot: 2 µg/ml

Aliases :

14-3-3, 1C5, HS1, 14-3-3 protein T-cell, 14-3-3 protein tau, 14-3-3 protein theta, protein tau

PubMed References :

16123035, 18078716, 18665908, 27151460

more info or order :

Invitrogen product webpage