NFkB p65 Polyclonal Antibody | Invitrogen 51-0500 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NFkB p65 Polyclonal Antibody

catalog :

51-0500

quantity :

100µg

price :

US 309.00

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, chromatin immunoprecipitation

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:250	Yapislar H, Taşkın E, Ozdas S, Akin D, Sonmez E. Counteraction of Apoptotic and Inflammatory Effects of Adriamycin in the Liver Cell Culture by Clinopitolite. Biol Trace Elem Res. 2016;170:373-81 pubmed publisher
chromatin immunoprecipitation; human	Hawkins P, Santoso S, Adams C, Anest V, Morris K. Promoter targeted small RNAs induce long-term transcriptional gene silencing in human cells. Nucleic Acids Res. 2009;37:2984-95 pubmed publisher
	Bobrovnikova-Marjon E, Marjon P, Barbash O, Vander Jagt D, Abcouwer S. Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: role of nuclear factor-kappaB and activating protein-1. Cancer Res. 2004;64:4858-69 pubmed
	Kashani-Sabet M, Shaikh L, Miller J, Nosrati M, Ferreira C, Debs R, et al. NF-kappa B in the vascular progression of melanoma. J Clin Oncol. 2004;22:617-23 pubmed
	Savkovic S, Koutsouris A, Hecht G. PKC zeta participates in activation of inflammatory response induced by enteropathogenic E. coli. Am J Physiol Cell Physiol. 2003;285:C512-21 pubmed
	Brown R, Mark K, Egleton R, Huber J, Burroughs A, Davis T. Protection against hypoxia-induced increase in blood-brain barrier permeability: role of tight junction proteins and NFkappaB. J Cell Sci. 2003;116:693-700 pubmed
	Dokladny K, Lobb R, Wharton W, Ma T, Moseley P. LPS-induced cytokine levels are repressed by elevated expression of HSP70 in rats: possible role of NF-kappaB. Cell Stress Chaperones. 2010;15:153-63 pubmed publisher
	Nava M, Quiroz Y, Vaziri N, Rodriguez-Iturbe B. Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats. Am J Physiol Renal Physiol. 2003;284:F447-54 pubmed

product information

Product Type :

Antibody

Product Name :

NFkB p65 Polyclonal Antibody

Catalog # :

51-0500

Quantity :

100µg

Price :

US 309.00

Clonality :

Polyclonal

Purity :

Antigen affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Non-human primate

Applications :

ChIP assay: 5µg, ELISA: 0.1-1.0 ug/ml, Immunocytochemistry: 1:100-1:500, Immunofluorescence: 1:100-1:500, Immunohistochemistry: 0.5-2 ug/ml, Western Blot: 1-3 ug/ml

Species :

Human, Mouse, Non-human primate

Isotype :

IgG

Storage :

-20°C

Description :

NF-kappaB (Nuclear Factor kappa B) is a nuclear transcription factor found in all cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, and bacterial or viral antigens. NF-kappaB plays a key role in regulating the immune response to infection. Consistent with this role, incorrect regulation of NF-kappaB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection and improper immune development. There are five members in the NF-kappaB family: NF-kappaB1, NF-kappaB2, RelA (also named p65), RelB, and c-Rel. The most common form of NF-kappaB is the p50/RelA heterodimer, although other forms of NF-kappaB dimers, such as p50/p50, p52/p52, p52/RelA, p50/c-Rel, c-Rel/c-Rel, p52/RelB, and p50/RelB, have also been identified in some types of cells. The primary role of NF-kappaB is to maintain normal cellular functions that range from cell-to-cell communication to cell motility, cell cycle progression, and cell lineage development. The activity of NF-kappaB is tightly regulated by interaction with inhibitory IkappaB proteins.

Immunogen :

A recombinant protein derived from the carboxyl terminal portion of the human NF-kappa-beta protein

Format :

Liquid

Applications w/Dilutions :

ChIP assay: 5µg, ELISA: 0.1-1.0 ug/ml, Immunocytochemistry: 1:100-1:500, Immunofluorescence: 1:100-1:500, Immunohistochemistry: 0.5-2 ug/ml, Western Blot: 1-3 ug/ml

Aliases :

RelA, NFKB3, Nuclear Factor kB p65 subunit, p65, Transcription Factor p65

PubMed References :

12441307, 12538770, 12900386, 14966085, 15256456, 19304753, 19551494, 26306587

more info or order :

Invitrogen product webpage