Estrogen Receptor alpha Monoclonal Antibody | Invitrogen 49-1002 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Estrogen Receptor alpha Monoclonal Antibody

catalog :

49-1002

quantity :

50µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:3000	Peña C, Champagne F. Neonatal overexpression of estrogen receptor-? alters midbrain dopamine neuron development and reverses the effects of low maternal care in female offspring. Dev Neurobiol. 2015;75:1114-24 pubmed publisher
immunohistochemistry - paraffin section; human	Yang B, Ma C, Chen Z, Yi W, McNutt M, Wang Y, et al. Correlation of immunoglobulin G expression and histological subtype and stage in breast cancer. PLoS ONE. 2013;8:e58706 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Estrogen Receptor alpha Monoclonal Antibody

Catalog # :

49-1002

Quantity :

50µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

ChIP assay: 5 µg, Immunohistochemistry: Assay Dependent, Western Blot: 7 µg/mL

Species :

Human

Isotype :

IgG3

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

Immunogen :

NH2 terminus of the human estrogen receptor alpha using a peptide antigen (Q19-K32) conjugated to KLH

Format :

Liquid

Applications w/Dilutions :

ChIP assay: 5 µg, Immunohistochemistry: Assay Dependent, Western Blot: 7 µg/mL

Aliases :

ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1

more info or order :

Invitrogen product webpage