Phospho-SHC (Ser36) Monoclonal Antibody (6E10) | Invitrogen 44828M product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-SHC (Ser36) Monoclonal Antibody (6E10)

catalog :

44828M

quantity :

50µL

price :

US 304.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

antigen modification :

phosphorylated

clone name :

6E10

reactivity :

human, mouse, dog

application :

western blot

product information

Product Type :

Antibody

Product Name :

Phospho-SHC (Ser36) Monoclonal Antibody (6E10)

Catalog # :

44828M

Quantity :

50µL

Price :

US 304.00

Clonality :

Monoclonal

Purity :

Size-exclusion chromatography

Host :

Mouse

Reactivity :

Canine, Human, Mouse

Applications :

Western Blot: 1µg/ml

Species :

Canine, Human, Mouse

Clone :

6E10

Isotype :

IgG1

Storage :

-20° C, Avoid Freeze/Thaw Cycles

Description :

Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span . Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis.

Immunogen :

Phosphopeptide containing amino acid sequence ELP[pS]PSA, conjugated to KLH.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1µg/ml

Aliases :

p66Shc, Shcp66, SH2 domain protein C1, SHC, SHC-transforming protein 1, SHCA, Src homology 2 domain-containing-transforming protein C1