Estrogen Receptor alpha Monoclonal Antibody (H4624) | Invitrogen 417000 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Estrogen Receptor alpha Monoclonal Antibody (H4624)

catalog :

417000

quantity :

100µg

price :

457 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

H4624

reactivity :

human, rat, sheep

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, flow cytometry

citations: 2

Published Application/Species/Sample/Dilution	Reference
flow cytometry; sheep; 1:10 immunohistochemistry; sheep; 1:50	Alexandre Pires G, Martins C, Galvão A, Correia M, Ramilo D, Quaresma M, et al. Morphological aspects and expression of estrogen and progesterone receptors in the interdigital sinus in cyclic ewes. Microsc Res Tech. 2014;77:313-25 pubmed
	Padilla Rodriguez M, Parker S, Adams D, Westerling T, Puleo J, Watson A, et al. The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion. Nat Commun. 2018;9:2980 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Estrogen Receptor alpha Monoclonal Antibody (H4624)

Catalog # :

417000

Quantity :

100µg

Price :

457 USD

Clonality :

Monoclonal

Purity :

Ammonium sulfate precipitation

Host :

Mouse

Reactivity :

Human, Rat

Applications :

ELISA: Assay Dependent, Immunohistochemistry: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Species :

Human, Rat

Clone :

H4624

Isotype :

IgG2a

Storage :

-20°C

Description :

Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

Immunogen :

Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human ER-alpha (2-180 aa).

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay Dependent, Immunohistochemistry: Assay Dependent, Immunoprecipitation: Assay Dependent, Western Blot: Assay Dependent

Aliases :

ER, ER-alpha, Estradiol receptor, Nuclear receptor subfamily 3 group A member 1, ESR1, ESR, NR3A1