NFkB p65 Monoclonal Antibody (2A12A7) | Invitrogen 33-9900 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NFkB p65 Monoclonal Antibody (2A12A7)

catalog :

33-9900

quantity :

100µg

price :

US 309.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2A12A7

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, immunohistochemistry - free floating section

more info or order :

Invitrogen product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - free floating section; mouse; fig 6 immunocytochemistry; mouse; fig 5 western blot; mouse; fig 1	Herkenham M, Rathore P, Brown P, Listwak S. Cautionary notes on the use of NF-κB p65 and p50 antibodies for CNS studies. J Neuroinflammation. 2011;8:141 pubmed publisher
immunocytochemistry; human; fig 1	Jagla B, Aulner N, Kelly P, Song D, Volchuk A, Zatorski A, et al. Sequence characteristics of functional siRNAs. RNA. 2005;11:864-72 pubmed
western blot; human; fig 4	Chen M, Tsai T, Lin Y, Tsai Y, Wang L, Lee M, et al. Antipsychotic drugs suppress the AKT/NF-κB pathway and regulate the differentiation of T-cell subsets. Immunol Lett. 2011;140:81-91 pubmed publisher
western blot; human	Lee Y, Wang E, Kumar N, Glickman R. Ursolic acid differentially modulates apoptosis in skin melanoma and retinal pigment epithelial cells exposed to UV-VIS broadband radiation. Apoptosis. 2014;19:816-28 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NFkB p65 Monoclonal Antibody (2A12A7)

Catalog # :

33-9900

Quantity :

100µg

Price :

US 309.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ChIP assay: 3 µg/ml, ELISA: Assay Dependent, Gel Shift: Assay Dependent, Western Blot: Assay Dependent

Species :

Human

Clone :

2A12A7

Isotype :

IgG2a

Storage :

-20°C

Description :

NF-kappaB (Nuclear Factor kappa B) is a nuclear transcription factor found in all cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, ultraviolet irradiation, and bacterial or viral antigens. NF-kappaB plays a key role in regulating the immune response to infection. Consistent with this role, incorrect regulation of NF-kappaB has been linked to cancer, inflammatory and autoimmune diseases, septic shock, viral infection and improper immune development. There are five members in the NF-kappaB family: NF-kappaB1, NF-kappaB2, RelA (also named p65), RelB, and c-Rel. The most common form of NF-kappaB is the p50/RelA heterodimer, although other forms of NF-kappaB dimers, such as p50/p50, p52/p52, p52/RelA, p50/c-Rel, c-Rel/c-Rel, p52/RelB, and p50/RelB, have also been identified in some types of cells. The primary role of NF-kappaB is to maintain normal cellular functions that range from cell-to-cell communication to cell motility, cell cycle progression, and cell lineage development. The activity of NF-kappaB is tightly regulated by interaction with inhibitory IkappaB proteins.

Immunogen :

Recombinant protein (~175 amino acids) from the C-terminal portion of human NF-kappa-B (p65).

Format :

Liquid

Applications w/Dilutions :

ChIP assay: 3 µg/ml, ELISA: Assay Dependent, Gel Shift: Assay Dependent, Western Blot: Assay Dependent

Aliases :

RelA, NFKB3, Nuclear Factor kB p65 subunit, p65, Transcription Factor p65

PubMed References :

15923373, 21763349, 21999414

more info or order :

Invitrogen product webpage