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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
c-Myc Monoclonal Antibody (9E10)
catalog :
13-2500
quantity :
200µg
price :
US 275.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9E10
reactivity :
Trypanosoma brucei, human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, other
more info or order :
citations: 99
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Shevchuk Z, Yurchenko M, Darekar S, Holodnuka Kholodnyuk I, Kashuba V, Kashuba E. Overexpression of MRPS18-2 in Cancer Cell Lines Results in Appearance of Multinucleated Cells. Acta Naturae. 2013;5:85-9 pubmed
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Loewen C, Young B, Tavassoli S, Levine T. Inheritance of cortical ER in yeast is required for normal septin organization. J Cell Biol. 2007;179:467-83 pubmed
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Itatsu K, Zen Y, Ohira S, Ishikawa A, Sato Y, Harada K, et al. Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis. Liver Int. 2007;27:1174-84 pubmed
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van Buul J, Allingham M, Samson T, Meller J, Boulter E, Garcia Mata R, et al. RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. J Cell Biol. 2007;178:1279-93 pubmed
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Ito K, Ikebe M, Kashiyama T, Mogami T, Kon T, Yamamoto K. Kinetic mechanism of the fastest motor protein, Chara myosin. J Biol Chem. 2007;282:19534-45 pubmed
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De Nicola F, Bruno T, Iezzi S, Di Padova M, Floridi A, Passananti C, et al. The prolyl isomerase Pin1 affects Che-1 stability in response to apoptotic DNA damage. J Biol Chem. 2007;282:19685-91 pubmed
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Brinkmann M, Spooner E, Hoebe K, Beutler B, Ploegh H, Kim Y. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling. J Cell Biol. 2007;177:265-75 pubmed
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Jones N, Hardy W, Friese M, Jorgensen C, Smith M, Woody N, et al. Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase. Mol Cell Biol. 2007;27:4759-73 pubmed
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Koo B, Longpre J, Somerville R, Alexander J, Leduc R, Apte S. Regulation of ADAMTS9 secretion and enzymatic activity by its propeptide. J Biol Chem. 2007;282:16146-54 pubmed
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Arola A, Sanchez X, Murphy R, Hasle E, Li H, Elliott P, et al. Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy. Mol Genet Metab. 2007;90:435-40 pubmed
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Wagner W, Fodor E, Ginsburg A, Hammer J. The binding of DYNLL2 to myosin Va requires alternatively spliced exon B and stabilizes a portion of the myosin's coiled-coil domain. Biochemistry. 2006;45:11564-77 pubmed
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O Donnell K, Yu D, Zeller K, Kim J, Racke F, Thomas Tikhonenko A, et al. Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis. Mol Cell Biol. 2006;26:2373-86 pubmed
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Spence H, McGarry L, Chew C, Carragher N, Scott Carragher L, Yuan Z, et al. AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins. Mol Cell Biol. 2006;26:1480-95 pubmed
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Iwata A, Riley B, Johnston J, Kopito R. HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin. J Biol Chem. 2005;280:40282-92 pubmed
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Aqeilan R, Donati V, Palamarchuk A, Trapasso F, Kaou M, Pekarsky Y, et al. WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function. Cancer Res. 2005;65:6764-72 pubmed
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Jansen S, Stefan C, Creemers J, Waelkens E, Van Eynde A, Stalmans W, et al. Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D. J Cell Sci. 2005;118:3081-9 pubmed
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Palamarchuk A, Efanov A, Maximov V, Aqeilan R, Croce C, Pekarsky Y. Akt phosphorylates Tal1 oncoprotein and inhibits its repressor activity. Cancer Res. 2005;65:4515-9 pubmed
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Liewen H, Meinhold Heerlein I, Oliveira V, Schwarzenbacher R, Luo G, Wadle A, et al. Characterization of the human GARP (Golgi associated retrograde protein) complex. Exp Cell Res. 2005;306:24-34 pubmed
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Torres V, Ivie S, McClain M, Cover T. Functional properties of the p33 and p55 domains of the Helicobacter pylori vacuolating cytotoxin. J Biol Chem. 2005;280:21107-14 pubmed
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Honda A, Al Awar O, Hay J, Donaldson J. Targeting of Arf-1 to the early Golgi by membrin, an ER-Golgi SNARE. J Cell Biol. 2005;168:1039-51 pubmed
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Goldstein A, Jan Y, Luo L. Function and regulation of Tumbleweed (RacGAP50C) in neuroblast proliferation and neuronal morphogenesis. Proc Natl Acad Sci U S A. 2005;102:3834-9 pubmed
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Mo Y, Yu Y, Theodosiou E, Ee P, Beck W. A role for Ubc9 in tumorigenesis. Oncogene. 2005;24:2677-83 pubmed
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Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, et al. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. EMBO J. 2005;24:473-86 pubmed
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Zhang J, Wang Y, Zhou Y, Cao Z, Huang P, Lu B. Yeast two-hybrid screens imply that GGNBP1, GGNBP2 and OAZ3 are potential interaction partners of testicular germ cell-specific protein GGN1. FEBS Lett. 2005;579:559-66 pubmed
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Sauvonnet N, Dujeancourt A, Dautry Varsat A. Cortactin and dynamin are required for the clathrin-independent endocytosis of gammac cytokine receptor. J Cell Biol. 2005;168:155-63 pubmed
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Pyagay P, Heroult M, Wang Q, Lehnert W, Belden J, Liaw L, et al. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ Res. 2005;96:261-8 pubmed
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Sakamoto K, Chao W, Katsube K, Yamaguchi A. Distinct roles of EGF repeats for the Notch signaling system. Exp Cell Res. 2005;302:281-91 pubmed
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Cardinale A, Filesi I, Vetrugno V, Pocchiari M, Sy M, Biocca S. Trapping prion protein in the endoplasmic reticulum impairs PrPC maturation and prevents PrPSc accumulation. J Biol Chem. 2005;280:685-94 pubmed
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Gao L, Macara I. Isoforms of the polarity protein par6 have distinct functions. J Biol Chem. 2004;279:41557-62 pubmed
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Kaplan D, Meigs T, Kelly P, Casey P. Identification of a role for beta-catenin in the establishment of a bipolar mitotic spindle. J Biol Chem. 2004;279:10829-32 pubmed
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Oliveria S, Gomez L, Dell Acqua M. Imaging kinase--AKAP79--phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J Cell Biol. 2003;160:101-12 pubmed
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Selim A, El Ayat G, Wells C. Expression of c-erbB2, p53, Bcl-2, Bax, c-myc and Ki-67 in apocrine metaplasia and apocrine change within sclerosing adenosis of the breast. Virchows Arch. 2002;441:449-55 pubmed
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Komada M, Soriano P. [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J Cell Biol. 2002;156:337-48 pubmed
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Park J, Bose A, Leszyk J, Czech M. PYK2 as a mediator of endothelin-1/G alpha 11 signaling to GLUT4 glucose transporters. J Biol Chem. 2001;276:47751-4 pubmed
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Hilairet S, Belanger C, Bertrand J, Laperriere A, Foord S, Bouvier M. Agonist-promoted internalization of a ternary complex between calcitonin receptor-like receptor, receptor activity-modifying protein 1 (RAMP1), and beta-arrestin. J Biol Chem. 2001;276:42182-90 pubmed
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Banno Y, Takuwa Y, Akao Y, Okamoto H, Osawa Y, Naganawa T, et al. Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3. J Biol Chem. 2001;276:35622-8 pubmed
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Laferriere J, Houle F, Taher M, Valerie K, Huot J. Transendothelial migration of colon carcinoma cells requires expression of E-selectin by endothelial cells and activation of stress-activated protein kinase-2 (SAPK2/p38) in the tumor cells. J Biol Chem. 2001;276:33762-72 pubmed
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Yoon K, Yoon M, Moir R, Khuon S, Flitney F, Goldman R. Insights into the dynamic properties of keratin intermediate filaments in living epithelial cells. J Cell Biol. 2001;153:503-16 pubmed
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Evan G, Lewis G, Ramsay G, Bishop J. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol Cell Biol. 1985;5:3610-6 pubmed
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product information
Product Type :
Antibody
Product Name :
c-Myc Monoclonal Antibody (9E10)
Catalog # :
13-2500
Quantity :
200µg
Price :
US 275.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
ELISA: 0.1-1.0 ug/ml, Gel Shift: Assay Dependent, Immunofluorescence: 2-10 ug/ml, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2-5 ug, Western Blot: 1-2 µg/ml
Species :
Human, Mouse
Clone :
9E10
Isotype :
IgG1, kappa
Storage :
-20°C
Description :
c-Myc is involved in the control of cell proliferation and differentiation and is amplified and/or overexpressed in a variety of tumors. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.
Immunogen :
A 32 amino acid synthetic peptide (aa 408-439) derived from the C-terminus of the human c-myc protein.
Format :
Liquid
Applications w/Dilutions :
ELISA: 0.1-1.0 ug/ml, Gel Shift: Assay Dependent, Immunofluorescence: 2-10 ug/ml, Immunohistochemistry (Paraffin): 1:100, Immunoprecipitation: 2-5 ug, Western Blot: 1-2 µg/ml
Aliases :
c Myc, Cellular myelocytomatosis oncogene, Myc protein, Myc proto oncogene protein, Myc2, Niard, Nird, v myc avian myelocytomatosis viral oncogene hom
PubMed References :
11278242, 11448946, 11468290, 11535606, 11535619, 11602570, 12447674, 14744872, 15196949, 15292221, 15513919, 15561108, 15618538, 15642376, 15660133, 15735760, 15738386, 15781476, 15817461, 15878329, 15930267, 15985467, 16061658, 16192271, 16449658, 16508012, 16981716, 17254821, 17403680, 17452444, 17468107, 17488711, 17919228, 19077040, 19139276, 19509056, 19581306, 19901077, 20093484, 20194507, 20809954, 21163940, 21325289, 21807902, 22205726, 22310662, 23129763, 23531275, 23535663, 23556133, 23750012, 24040268, 24086303, 24651769, 24880126, 25672245, 25691595, 25770584, 25808593, 26113042, 26119733, 26389695, 26399325, 26414348, 26509500, 26645068, 26761346, 26822694, 26995145, 27129278, 27297360, 27303034, 27436903, 27687499, 27810336, 27991487, 28094338, 28176809, 28485388, 28827831, 3915782
more info or order :
company information

Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
800-678-5599
headquarters: USA
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