product summary
request information :
company name :
GeneTex
product type :
antibody
product name :
p21 Cip1 antibody [EPR3993]
catalog :
GTX62525
quantity :
100.00μl
price :
329 USD
clonality :
monoclonal
host :
rabbit
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 1
Patrushev N, Seidel-Rogol B, Salazar G. Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells. PLoS ONE. 2012;7:e33211 pubmed publisher
image
image 1 :
GeneTex GTX62525 image 1
Immunohistochemical staining of paraffin-embedded human colon tissue using anti-p21 RabMAb (cat. #GTX62525).
image 2 :
GeneTex GTX62525 image 2
Immunohistochemical staining of paraffin-embedded human stomach adenocarcinoma tissue using anti-p21 RabMAb (cat. #GTX62525).
image 3 :
GeneTex GTX62525 image 3
Western blot analysis on (A) HUVEC (B) U87-MG and (C) C6 cell lysates using anti-p21 RabMAb (cat. # GTX62525).
product information
Catalog No :
GTX62525
Product Name :
p21 Cip1 antibody [EPR3993]
Host Species :
Rabbit
Clonality :
Monoclonal
Product Type :
Primary antibody
Size :
100.00μl
List Price :
329 USD
list of Pubmed id :
22427991
Clone :
EPR3993
Isotype :
IgG
Product Description :
Rabbit monoclonal antibody [EPR3993] to p21 Cip1
CrossReactivity :
Hu, Ms, Rat
Background :
Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1, p21, CDKN1A, WAF1) plays a critical role in the cellular response to DNA damage, and its overexpression results in cell cycle arrest . p21 binds to and inhibits CDK activity, preventing phosphorylation of critical CDK substrates and blocking cell cycle progression. p21 is suggested to possibly be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage . Endogenous cellular p21 is shown to be completely acetylated at its amino terminus and is therefore not a substrate for N-ubiquitylation .
Immunogen :
A synthetic peptide corresponding to residues in human p21 was used as an immunogen.
Buffer :
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
Uses :
ICC/IF, IHC-P, IP, WB
General References :
Store at -20 °C. Stable for 12 months from date of receipt.
more info or order :
company information
GeneTex
2456 Alton Pkwy
Irvine, CA92606
info@genetex.com
www.genetex.com
1-877-436-3839
headquarters: USA