Ras antibody [Y13-259] | GeneTex GTX13056 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

GeneTex

product type :

antibody

product name :

Ras antibody [Y13-259]

catalog :

GTX13056

quantity :

50.00μg

price :

289 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

Y13-259

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

product information

Catalog No :

GTX13056

Product Name :

Ras antibody [Y13-259]

Host Species :

Rat

Clonality :

Monoclonal

Product Type :

Primary antibody

Size :

50.00μg

List Price :

289 USD

Clone :

Y13-259

Isotype :

IgG

Product Description :

Rat monoclonal antibody [Y13-259] to Ras

CrossReactivity :

Hu, Ms, Rat

Background :

This gene belongs to the Ras oncogene family, whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes function in signal transduction pathways. These proteins can bind GTP and GDP, and they have intrinsic GTPase activity. This protein undergoes a continuous cycle of de- and re-palmitoylation, which regulates its rapid exchange between the plasma membrane and the Golgi apparatus. Mutations in this gene cause Costello syndrome, a disease characterized by increased growth at the prenatal stage, growth deficiency at the postnatal stage, predisposition to tumor formation, mental retardation, skin and musculoskeletal abnormalities, distinctive facial appearance and cardiovascular abnormalities. Defects in this gene are implicated in a variety of cancers, including bladder cancer, follicular thyroid cancer, and oral squamous cell carcinoma. Multiple transcript variants, which encode different isoforms, have been identified for

Immunogen :

Recombinant full length p21 protein (Human).

Specificity :

Monoclonal Anti-vH RAS reacts with phosphorylated and non-phosphorylated forms of vH RAS and vK RAS p21's and reacts with the p21 transitional products of the H, K, and N ras human genes. It does not crossreact with Rap. This antibody neutralizes the activity of H, K, and NRas by binding to residues Glu-63, Ser-65, Ala-66, Met-67, Gln-70 and Arg-73.

Buffer :

Preservative: 0.1% Sodium Azide; Constituents: 0.2% gelatin, 0.05M Sodium Phosphate. pH 7.5

Uses :

ICC/IF, IHC-Fr, IHC-P, IP, WB

Concentration :

0.1mg/ml