PhosphoDetect™ Anti-NBS1 (pSer343) Rabbit pAb | EMD Millipore PC635-50UL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PhosphoDetect™ Anti-NBS1 (pSer343) Rabbit pAb

catalog :

PC635-50UL

quantity :

50 uL

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunoprecipitation

product information

Catalog Number :

PC635-50UL

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

PhosphoDetect™ Anti-NBS1 (pSer343) Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

4683 (Hu), 27354 (Ms), 85482 (Rt)

Host Name :

Conjugate :

Diluted Serum

Isotype :

IgG

Product Description :

PhosphoDetect™ Anti-NBS1 (pSer343) Rabbit pAb

Cross Reactivity :

Human

Background :

Nibrin, a ~95 kDa double stranded DNA repair protein, is mutated in Nijmegen breakage syndrome (NBS). Patients with NBS exhibit chromosomal instability, resulting in hypersensitivity to irradiation and cancer predisposition. Nibrin forms a manganese-sensitive complex with hMre11 and hRAD50 that has single strand DNA endonuclease and exonuclease activities and is likely to be important for DNA excision, repair, and stability. This nibrin/Mre11/RAD50 complex is inhibited by BRCA1. The ATM (ataxia telangiectasia mutated) kinase has been shown to phosphorylate nibrin in an S-phase checkpoint pathway. Nibrin levels are elevated in testis tissue, suggesting a possible role in meiotic recombination. Nibrin may also be involved in telomere length maintenance.

ALT Names :

AT-V1, AT-V2, ATV, FLJ10155, MGC87362, MGC93174, NBS, NBS1, NIBRIN, P95, p95/nibrin, nibrin

Immunogen :

a synthetic phosphopeptide [TPGPSLpSQGVSVD(C)] corresponding to amino acids 337-349 surrounding the Ser 343 phosphorylation site of human nibrin, conjugated to diphtheria toxoid

Specificity :

Recognizes the ~95 kDa nibrin (NBS1) protein phosphorylated at Ser 343 .

Package Size :

50 uL

Uses :

ELISA, WB, IP

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.