Polypyrimidine Tract Binding Protein (Ab-1) Mouse mAb (SH54) | EMD Millipore NA63-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Polypyrimidine Tract Binding Protein (Ab-1) Mouse mAb (SH54)

catalog :

NA63-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

NA63-100UG

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-Polypyrimidine Tract Binding Protein (Ab-1) Mouse mAb (SH54)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

5725 (Hu), 19205 (Ms), 29497 (Rt)

Host Name :

Clone :

SH54

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Polypyrimidine Tract Binding Protein (Ab-1) Mouse mAb (SH54)

Cross Reactivity :

Human

Background :

Polypyrimidine tract binding protein (PTB) is an abundant vertebrate hnRNP protein that functions as a splicing regulator with multiple targets. PTB exists as a 57 kDa protein that is found exclusively in the perinucleolar compartment (PNC) and regulates alternative splicing by binding to a specific pyrimidine tract sequence that is typically found near the 3' end of introns. The PNC in turn is a structure that is more prevalent in cancer cells than in normal cells. This latter observation suggests the possibility of using expression of PTB as a marker for tumor cells. In solution phase, PTB exists as a homodimer and in some cancer cells exists as two isoforms, the ratio of which appears to correlate with metastatic potential particularly in prostatic carcinoma. PTB is involved in the regulation of many different viral genomes such as that of hepatitis C virus.

ALT Names :

AA407203, AL033359, HNRNP-I, HNRPI, MGC10830, MGC8461, pPTB, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, Pybp, Pybp1, Pybp2, polypyrimidine tract binding protein 1

Immunogen :

HeLa cell nuclear extract

Specificity :

Recognizes the ~57 kDa PTB protein.

Package Size :

100 ug

Uses :

WB, IF, IH(P)

Storage :

Do not freeze