LRRK2 Antibody, clone N138/6 | EMD Millipore MABN40 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

LRRK2 Antibody, clone N138/6

catalog :

MABN40

quantity :

100 μg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

N138/6

The same clone is also sold as:

OriGene: 75-188, 73-188
Neuromab: 75-188, 73-188

reactivity :

human, mouse

application :

western blot, immunohistochemistry

citations: 2

Reference
Chia R, Haddock S, Beilina A, Rudenko I, Mamais A, Kaganovich A, et al. Phosphorylation of LRRK2 by casein kinase 1Î± regulates trans-Golgi clustering via differential interaction with ARHGEF7. Nat Commun. 2014;5:5827 pubmed publisher
Attwood T, Kell D, McDermott P, Marsh J, Pettifer S, Thorne D. Utopia documents: linking scholarly literature with research data. Bioinformatics. 2010;26:i568-74 pubmed publisher

product information

Catalog Number :

MABN40

Subcategory :

Cell Signaling

Product Name :

Anti-LRRK2 Antibody, clone N138/6

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

Q5S007

Host Name :

Mouse

Antigen :

LRRK2

Clone :

N138/6

Conjugate :

Purified

Isotype :

IgG1κ

Product Description :

Anti-LRRK2 Antibody, clone N138/6

Cross Reactivity :

Human;Mouse

Background :

Leucine-rich repeat kinase 2 (LRRK2) is a 2,527 amino acid protein encoded by the PARK8 gene and belonging to the ROCO family of proteins. This protein family is characterized as having a unique interaction between the Roc domain and the intrinsic GTPase activity along with a COR domain. LRKK2 consists of 5 different domains; a tyrosine kinase-like MAPKKK-related domain, WD40 propeller motif repeats, a Roc (Ras-like small GTPase family) domain, a COR (C-terminal of Roc) domain, and an LRRK. LRRK2 is mainly localized to the cytoplasm and expression within tissue is most highly observed within the brain. It is found in lower levels within the liver, heart, lung, skeletal muscles, placenta, pancreas, and kidney. The exact function of LRRK2 is unknown; however mutations to any of the five domains are the most commonly known causes of Parkinson’s disease, both familial and sporadic. Further study of this protein may lead to a better understanding of the disease’s pathogenesis, as well as potential therapeutic markers.

ALT Names :

leucine-rich repeat kinase 2;DARDARIN;augmented in rheumatoid arthritis 17;Parkinson disease (autosomal dominant) 8;Dardarin

Immunogen :

Recombinant protein corresponding to human LRRK2.

Specificity :

This antibody recognizes LRRK2.

Package Size :

100 μg

Uses :

Immunohistochemistry;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt