Milli-Mark™ Anti-PLK1-FITC Antibody, clone 35-206 | EMD Millipore FCMAB405F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Milli-Mark™ Anti-PLK1-FITC Antibody, clone 35-206

catalog :

FCMAB405F

quantity :

100 tests

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

35-206

The same clone is also sold as:

Invitrogen: 37-7000
MilliporeSigma: P5998
Abcam: ab17056

reactivity :

mouse

application :

flow cytometry

citations: 4

Reference
Matthess Y, Raab M, Knecht R, Becker S, Strebhardt K. Sequential Cdk1 and Plk1 phosphorylation of caspase-8 triggers apoptotic cell death during mitosis. Mol Oncol. 2014;8:596-608 pubmed publisher
Rodriguez Acebes S, Proctor I, Loddo M, Wollenschlaeger A, Rashid M, Falzon M, et al. Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers. Am J Pathol. 2010;177:2034-45 pubmed publisher
Gilmartin A, Bleam M, Richter M, Erskine S, Kruger R, Madden L, et al. Distinct concentration-dependent effects of the polo-like kinase 1-specific inhibitor GSK461364A, including differential effect on apoptosis. Cancer Res. 2009;69:6969-77 pubmed publisher
Spyer M, Allday M. The transcriptional co-repressor C-terminal binding protein (CtBP) associates with centrosomes during mitosis. Cell Cycle. 2006;5:530-7 pubmed

product information

Catalog Number :

FCMAB405F

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Milli-Mark™ Anti-PLK1-FITC Antibody, clone 35-206

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P53350

Host Name :

Mouse

Antigen :

PLK1-FITC

Clone :

35-206

Conjugate :

FITC

Isotype :

IgG2b

Product Description :

Milli-Mark™ Anti-PLK1-FITC Antibody, clone 35-206

Cross Reactivity :

Mouse

Background :

Polo-like Kinase 1 (PLK-1) is a serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Expressed PLK-1 protein accumulates to a maximum during the G2 and M phases, declines to a nearly undetectable level following mitosis and throughout G1 phase, and then begins to accumulate again during S phase.

ALT Names :

Polo-like kinase 1;Serine/threonine-protein kinase 13;cell cycle regulated protein kinase;polo (Drosophia)-like kinase;polo like kinase

Immunogen :

6 histidine-tagged full length fusion protein corresponding to human polo-like kinase 1 (PLK1).

Specificity :

Antibody recognizes PLK1.

Package Size :

100 tests

Uses :

Flow Cytometry

Storage :

Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.