DISC1 Antibody | EMD Millipore ABN308 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

DISC1 Antibody

catalog :

ABN308

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

ABN308

Subcategory :

Neuroscience

Product Name :

Anti-DISC1 Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q9NRI5

Host Name :

Rabbit

Antigen :

DISC1

Conjugate :

Affinity Purified

Product Description :

Anti-DISC1 Antibody

Cross Reactivity :

Human;Rat;Mouse

Background :

Disrupted in schizophrenia 1 (DISC1) is a candidate gene for susceptibility to schizophrenia. It was discovered through chromosomal analysis of a large Scottish family whose members exhibited schizophrenia and related psychiatric disorders. Through yeast two-hybrid screening, it was discovered that DISC1 interacts with many members of the centrosome and cytoskeletal system including MAP1A and Nudel. More recently, DISC1 has been found to regulate the transport of a complex containing Nudel, the lissencephaly-1 (LIS1) protein, and 14-3-3epsilon from neuronal cell bodies to the axons by the action of the microtubule-dependent directed motor protein kinesin-1, also known as KIF5A. Decreased expression of DISC1 in neurons caused an accelerated rate of neuronal integration, resulting in aberrant morphological development, suggesting that DISC1 plays a role in dendritic development and synapse formation. DISC1 has at least four known isoforms.

ALT Names :

Disrupted in schizophrenia 1

Immunogen :

KLH-conjugated linear peptide corresponding to human DISC1.

Package Size :

100 μg

Uses :

Immunohistochemistry;Immunocytochemistry;Western Blotting

Storage :

Stable for 1 year at 2-8°C from date of receipt