IASPP (CT) Antibody | EMD Millipore AB10612 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

IASPP (CT) Antibody

catalog :

AB10612

quantity :

100 µg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

AB10612

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-IASPP (CT) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q8WUF5

Host Name :

Rabbit

Antigen :

IASPP (CT)

Conjugate :

Purified

Product Description :

Anti-IASPP (CT) Antibody

Cross Reactivity :

Human

Background :

iASPP (inhibitor of apoptosis stimulating protein of p53, RelA-associated inhibitor (RAI), NFκB-interacting protein 1, protein phosphatase 1 regulatory subunit 13-like, PPP1R13L) is the third member of the ASPP family of proteins. Unlike ASPP1 and ASPP2, which interact with p53 and enhance its ability to induce apoptosis, iASPP inhibits apoptosis induced by p53 overexpression. iASPP has been identified in a yeast-two hybrid screen as an interacting protein of the p65 subunit of NFκB (RelA),3 interacts with NFκB in vivo, and acts as an efficient inhibitor of HIV-1 gene expression in which both NFκb and Sp1 play major roles. iASPP expression is upregulated in human breast carcinomas expressing wild-type p53, and gene overexpression may play an important role in the leukemogenesis and/or progression of acute leukemia.

Immunogen :

Synthetic peptide derived from the C-terminal region of the human, mouse, and bovine iASPP proteins.

Specificity :

Recognizes IASPP (C-Terminal).

Package Size :

100 µg

Uses :

Western Blotting

Storage :

Freeze -20°C.