BACE (487-501) Rabbit pAb | EMD Millipore 195102-100UL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

BACE (487-501) Rabbit pAb

catalog :

195102-100UL

quantity :

100 uL

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

product information

Catalog Number :

195102-100UL

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-BACE (487-501) Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

23621 (Hu), 23821 (Ms), 29392 (Rt)

Host Name :

Conjugate :

Undiluted Serum

Isotype :

IgG

Product Description :

Anti-BACE (487-501) Rabbit pAb

Cross Reactivity :

Hamster, Human

Background :

BACE (beta-secretase, beta-site APP-cleaving enzyme) is a 70 kDa membrane associated aspartyl protease that is involved in the two step cleavage of amyloid beta-peptide in the development of Alzheimer's disease. Once synthesized as a proteolytically inactive precursor form, the BACE protein undergoes post-translational modification in the ER, losing the pro-peptide and becomes glycosylated. The modified, mature protein is transported to the Golgi and then continues its migration to the membrane. Once in the membrane, BACE functions as the major source of beta-secretase activity. BACE2, a homolog of BACE, has also been identified. BACE2 differs from BACE in that it is highly expressed in multiple tissues including colon, pancreas, and prostate rather than being restricted to the brain.

ALT Names :

ASP2, BACE, BETA SECRETASE, C76936, FLJ90568, HSPC104, KIAA1149, MEMAPSIN 2, beta-site APP-cleaving enzyme 1

Immunogen :

a synthetic peptide [(C)RQQHDDFADDISLLK] corresponding to amino acids 487-501 of human BACE

Specificity :

Recognizes the ~65 kDa and ~75 kDa glycosylated forms of the BACE protein.

Package Size :

100 uL

Uses :

WB, IP

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.