phospho-B-Raf (Ser445) Antibody | EMD Millipore 07-1343 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-B-Raf (Ser445) Antibody

catalog :

07-1343

quantity :

100 μg

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dog, chicken

application :

western blot

product information

Catalog Number :

07-1343

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-phospho-B-Raf (Ser445) Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

P15056

Host Name :

Rabbit

Antigen :

phospho-B-Raf (Ser445)

Conjugate :

Affinity Purified

Product Description :

Anti-phospho-B-Raf (Ser445) Antibody

Cross Reactivity :

Mouse;Rat;Human;Xenopus;Chicken;Canine;Horse

Background :

The Raf proteins (Raf-1, A-Raf, B-Raf) are Ser/Thr kinases with homology to the PKC family, containing an N-terminal regulatory domain and a C-terminal catalytic domain. Members of the Raf family bind to activated Ras GTPase, which results in Raf translocation to the plasma membrane and activation. Activated Raf proteins phosphorylate MEKs, and are therefore the principle transducers of signals from Ras to MAP kinase. B-Raf acts as a signal transducer from membrane-associated receptors to nuclear transcription factors. B-Raf is important for the regulation of cell proliferation and determination of cell fate during embryogenesis. B-Raf acts downstream of Ras and upstream of MEK in the Ras-Raf-MEK-ERK signal transduction pathway, which is a conserved RAS-activated protein kinase cascade that regulates cell growth, proliferation, and differentiation in response to growth factors, cytokines, and hormones.

ALT Names :

B-RAF;B-Raf;BRAF1;p94;Raf;RAF

Immunogen :

KLH-conjugated linear peptide corresponding to human B-Raf phosphorylated at and around Ser445.

Specificity :

Antibody recognizes B-Raf phosphorylated at and around Ser445.

Package Size :

100 μg

Uses :

Western Blotting;Enzyme Assay

Storage :

Stable for 1 year at 2-8°C from date of receipt