SynGAP Antibody | EMD Millipore 06-900 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

SynGAP Antibody

catalog :

06-900

quantity :

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

mouse

application :

western blot, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:2000; loading ...; fig 4c	Tanabe Y, Naito Y, Vasuta C, Lee A, Soumounou Y, Linhoff M, et al. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2?. Nat Commun. 2017;8:408 pubmed publisher

product information

Catalog Number :

06-900

Subcategory :

Neuroscience

Product Name :

Anti-SynGAP Antibody

Product Type :

Antibodies

Clonality :

Polyclonal Antibody

Gene ID :

Q96PV0

Host Name :

Rabbit

Antigen :

SynGAP

Conjugate :

Purified

Product Description :

Anti-SynGAP Antibody

Cross Reactivity :

Rat

Background :

Silent synapses, or excitatory synapses that lack functional -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs), are thought to be critical for regulation of neuronal circuits and synaptic plasticity. SynGAP, an excitatory synapse-specific RasGAP, regulates AMPAR trafficking, silent synapse number, and excitatory synaptic transmission in hippocampal and cortical cultured neurons. Over expression of SynGAP in neurons results in a remarkable depression of AMPAR-mediated miniature excitatory postsynaptic currents, a significant reduction in synaptic AMPAR surface expression, and a decrease in the insertion of AMPARs into the plasma membrane. Synaptic transmission is increased in neurons from SynGAP knockout mice as well as in neuronal cultures treated with SynGAP small interfering RNA.

Immunogen :

peptide (KRLLDAQRGSFPPWVQQTRV) corresponding to amino acids 1274-1293 of rat SynGAP-a

Specificity :

SynGAP

Package Size :

Uses :

Immunocytochemistry;Western Blotting

Storage :

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.