product summary
request information :
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem
product type :
antibody
product name :
Anti-Active-β-Catenin (Anti-ABC) Antibody, clone 8E7
catalog :
05-665
quantity :
100 μg
price :
clonality :
monoclonal
host :
mouse
reactivity :
zebrafish , human
application :
immunohistochemistry - paraffin section, western blot, immunohistochemistry, immunocytochemistry, flow cytometry
publications citing this reagent :
  1. WB
    Ray S, Xu F, Wang H, Das S. Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. Mol Endocrinol. 2008;22:1125-40 pubmed publisher
more info or order :
product information
Catalog Number :
05-665
Subcategory :
Epigenetics & Nuclear Function
Product Name :
Anti-Active-β-Catenin (Anti-ABC) Antibody, clone 8E7
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P35222
Host Name :
Mouse
Antigen :
Active-β-Catenin (ABC)
Clone :
8E7
Conjugate :
Purified
Isotype :
IgG1κ
Product Description :
Anti-Active-β-Catenin (Anti-ABC) Antibody, clone 8E7
Cross Reactivity :
Human;Mouse;Rat
Background :
Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. When β-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in β-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When β-catenin is not associated with cadherins and α-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that β-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy. HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.
Immunogen :
Fusion protein corresponding to residues 1-100 of human β-catenin with a c-terminal histidine tag
Specificity :
Recognizes active form of β-catenin, dephosphorylated on Ser37 or Thr41.
Package Size :
100 μg
Uses :
Flow Cytometry;Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting
Storage :
Maintain for 1 year at 2-8°C from date of shipment. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
more info or order :
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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