product summary
request information :
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Anti-Active-β-Catenin (Anti-ABC) Antibody, clone 8E7
catalog :
05-665
quantity :
100 μg
clonality :
monoclonal
host :
mouse
reactivity :
human, mouse, zebrafish , Rhesus monkey
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 85
Published Application/Species/DilutionReference
  • immunohistochemistry - paraffin section; mouse; fig 4
  • western blot; human; fig 5
Cheng Y, Phoon Y, Jin X, Chong S, Ip J, Wong B, et al. Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget. 2015;6:14428-39 pubmed
  • immunoprecipitation; human
  • immunohistochemistry; human
Burkhalter R, Westfall S, Liu Y, Stack M. Lysophosphatidic Acid Initiates Epithelial to Mesenchymal Transition and Induces β-Catenin-mediated Transcription in Epithelial Ovarian Carcinoma. J Biol Chem. 2015;290:22143-54 pubmed publisher
  • western blot; mouse
Bisson J, Mills B, Paul Helt J, Zwaka T, Cohen E. Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT. Dev Biol. 2015;398:80-96 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500
Sakamaki A, Katsuragi Y, Otsuka K, Tomita M, Obata M, Iwasaki T, et al. Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after γ-irradiation through Wnt/β-catenin pathway. Carcinogenesis. 2015;36:622-31 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50
McBryan J, Fagan A, McCartan D, Bane F, Varešlija D, Cocchiglia S, et al. Transcriptomic Profiling of Sequential Tumors from Breast Cancer Patients Provides a Global View of Metastatic Expression Changes Following Endocrine Therapy. Clin Cancer Res. 2015;21:5371-9 pubmed publisher
  • western blot; human
Jia D, Yang W, Li L, Liu H, Tan Y, Ooi S, et al. β-Catenin and NF-κB co-activation triggered by TLR3 stimulation facilitates stem cell-like phenotypes in breast cancer. Cell Death Differ. 2015;22:298-310 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:200; fig 4i
Yuan G, Yang G, Zheng Y, Zhu X, Chen Z, Zhang Z, et al. The non-canonical BMP and Wnt/β-catenin signaling pathways orchestrate early tooth development. Development. 2015;142:128-39 pubmed publisher
  • western blot; human
Kim K, Ossipova O, Sokol S. Neural crest specification by inhibition of the ROCK/Myosin II pathway. Stem Cells. 2015;33:674-85 pubmed publisher
  • immunocytochemistry; human; 1:100
  • western blot; human; 1:1000
Joseph J, Conroy S, Tomar T, Eggens-Meijer E, Bhat K, Copray S, et al. TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion. Cell Death Dis. 2014;5:e1443 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Isobe T, Hisamori S, Hogan D, Zabala M, Hendrickson D, Dalerba P, et al. miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway. elife. 2014;3: pubmed publisher
  • western blot; mouse; 1:2500
Forsdahl S, Kiselev Y, Hogseth R, Mjelle J, Mikkola I. Pax6 regulates the expression of Dkk3 in murine and human cell lines, and altered responses to Wnt signaling are shown in FlpIn-3T3 cells stably expressing either the Pax6 or the Pax6(5a) isoform. PLoS ONE. 2014;9:e102559 pubmed publisher
  • western blot; mouse
Etnyre D, Stone A, Fong J, Jacobs R, Uppada S, Botting G, et al. Targeting c-Met in melanoma: mechanism of resistance and efficacy of novel combinatorial inhibitor therapy. Cancer Biol Ther. 2014;15:1129-41 pubmed publisher
  • western blot; human
Thu K, Radulovich N, Becker-Santos D, Pikor L, Pusic A, Lockwood W, et al. SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signaling. Oncogene. 2014;33:279-88 pubmed publisher
  • flow cytometry; human; fig 7g
Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, et al. REST and stress resistance in ageing and Alzheimer's disease. Nature. 2014;507:448-54 pubmed publisher
  • western blot; human
Svedlund J, Barazeghi E, Stalberg P, Hellman P, Akerstrom G, Björklund P, et al. The histone methyltransferase EZH2, an oncogene common to benign and malignant parathyroid tumors. Endocr Relat Cancer. 2014;21:231-9 pubmed publisher
  • immunocytochemistry; mouse
  • western blot; mouse
Wang H, Sun W, Ma J, Pan Y, Wang L, Zhang W. Polycystin-1 mediates mechanical strain-induced osteoblastic mechanoresponses via potentiation of intracellular calcium and Akt/β-catenin pathway. PLoS ONE. 2014;9:e91730 pubmed publisher
  • western blot; human
Guezguez A, Paré F, Benoit Y, Basora N, Beaulieu J. Modulation of stemness in a human normal intestinal epithelial crypt cell line by activation of the WNT signaling pathway. Exp Cell Res. 2014;322:355-64 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50
Yukata K, Xie C, Li T, Takahata M, Hoak D, Kondabolu S, et al. Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment. Bone. 2014;62:79-89 pubmed publisher
  • immunocytochemistry; human; 1:150
  • western blot; human; 1:1000
Skalka N, Caspi M, Caspi E, Loh Y, Rosin-Arbesfeld R. Carboxypeptidase E: a negative regulator of the canonical Wnt signaling pathway. Oncogene. 2013;32:2836-47 pubmed publisher
  • chromatin immunoprecipitation; human
  • immunoprecipitation; human
  • immunocytochemistry; human
  • western blot; human
Yu Y, Qi L, Wu J, Wang Y, Fang W, Zhang H. Kindlin 2 regulates myogenic related factor myogenin via a canonical Wnt signaling in myogenic differentiation. PLoS ONE. 2013;8:e63490 pubmed publisher
  • western blot; human; 1:400
Luijten M, Basten S, Claessens T, Vernooij M, Scott C, Janssen R, et al. Birt-Hogg-Dube syndrome is a novel ciliopathy. Hum Mol Genet. 2013;22:4383-97 pubmed publisher
  • western blot; human
Han J, Soletti R, Sadarangani A, Sridevi P, Ramirez M, Eckmann L, et al. Nuclear expression of β-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res. 2013;11:207-18 pubmed publisher
  • western blot; human; 1:2000
Li Y, Zheng Y, Izumi K, Ishiguro H, Ye B, Li F, et al. Androgen activates β-catenin signaling in bladder cancer cells. Endocr Relat Cancer. 2013;20:293-304 pubmed publisher
  • immunocytochemistry; mouse; 1:200
  • western blot; mouse; 1:2000
Naito M, Mikami Y, Takagi M, Takahashi T. Up-regulation of Axin2 by dexamethasone promotes adipocyte differentiation in ROB-C26 mesenchymal progenitor cells. Cell Tissue Res. 2013;354:761-70 pubmed publisher
  • immunohistochemistry - paraffin section; human
Urdinguio R, Fernandez A, Moncada-Pazos A, Huidobro C, Rodriguez R, Ferrero C, et al. Immune-dependent and independent antitumor activity of GM-CSF aberrantly expressed by mouse and human colorectal tumors. Cancer Res. 2013;73:395-405 pubmed publisher
  • western blot; mouse
Styner M, Meyer M, Galior K, Case N, Xie Z, Sen B, et al. Mechanical strain downregulates C/EBPβ in MSC and decreases endoplasmic reticulum stress. PLoS ONE. 2012;7:e51613 pubmed publisher
  • western blot; human; 2 ug/ml
McClain C, Sim F, Goldman S. Pleiotrophin suppression of receptor protein tyrosine phosphatase-β/ζ maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells. J Neurosci. 2012;32:15066-75 pubmed publisher
  • western blot; mouse; 1:1000; fig 4
MARCIANO D, BRAKEMAN P, Lee C, Spivak N, Eastburn D, Bryant D, et al. p120 catenin is required for normal renal tubulogenesis and glomerulogenesis. Development. 2011;138:2099-109 pubmed publisher
  • ELISA; Rhesus monkey; 1:300; fig 2
Cheng X, Huber T, Chen V, Gadue P, Keller G. Numb mediates the interaction between Wnt and Notch to modulate primitive erythropoietic specification from the hemangioblast. Development. 2008;135:3447-58 pubmed publisher
Jansen S, Holman R, Hedemann I, Frankes E, Elzinga C, Timens W, et al. Prostaglandin E2 promotes MYCN non-amplified neuroblastoma cell survival via β-catenin stabilization. J Cell Mol Med. 2015;19:210-26 pubmed publisher
Xie Q, Chen L, Shan X, Shan X, Tang J, Zhou F, et al. Epigenetic silencing of SFRP1 and SFRP5 by hepatitis B virus X protein enhances hepatoma cell tumorigenicity through Wnt signaling pathway. Int J Cancer. 2014;135:635-46 pubmed publisher
Bhushan B, Walesky C, Manley M, Gallagher T, Borude P, Edwards G, et al. Pro-regenerative signaling after acetaminophen-induced acute liver injury in mice identified using a novel incremental dose model. Am J Pathol. 2014;184:3013-25 pubmed publisher
Umazume K, Tsukahara R, Liu L, Fernandez de Castro J, McDonald K, Kaplan H, et al. Role of retinal pigment epithelial cell β-catenin signaling in experimental proliferative vitreoretinopathy. Am J Pathol. 2014;184:1419-28 pubmed publisher
Easter S, Mitchell E, Baxley S, Desmond R, Frost A, Serra R. Wnt5a suppresses tumor formation and redirects tumor phenotype in MMTV-Wnt1 tumors. PLoS ONE. 2014;9:e113247 pubmed publisher
Sun T, Co N, Wong N. PFTK1 interacts with cyclin Y to activate non-canonical Wnt signaling in hepatocellular carcinoma. Biochem Biophys Res Commun. 2014;449:163-8 pubmed publisher
Zahoor M, Cha P, Choi K. Indirubin-3'-oxime, an activator of Wnt/β-catenin signaling, enhances osteogenic commitment of ST2 cells and restores bone loss in high-fat diet-induced obese male mice. Bone. 2014;65:60-8 pubmed publisher
Antony L, van der Schoor F, Dalrymple S, Isaacs J. Androgen receptor (AR) suppresses normal human prostate epithelial cell proliferation via AR/β-catenin/TCF-4 complex inhibition of c-MYC transcription. Prostate. 2014;74:1118-31 pubmed publisher
Li L, Ying J, Tong X, Zhong L, Su X, Xiang T, et al. Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas. Cell Mol Life Sci. 2014;71:2179-92 pubmed publisher
Schlupf J, Steinbeisser H. IGF antagonizes the Wnt/β-Catenin pathway and promotes differentiation of extra-embryonic endoderm. Differentiation. 2014;87:209-19 pubmed publisher
Kang W, Tong J, Chan A, Zhao J, Dong Y, Wang S, et al. Yin Yang 1 contributes to gastric carcinogenesis and its nuclear expression correlates with shorter survival in patients with early stage gastric adenocarcinoma. J Transl Med. 2014;12:80 pubmed publisher
Li C, Zhang S, Lu Y, Zhang Y, Wang E, Cui Z. The roles of Notch3 on the cell proliferation and apoptosis induced by CHIR99021 in NSCLC cell lines: a functional link between Wnt and Notch signaling pathways. PLoS ONE. 2013;8:e84659 pubmed publisher
Li Q, Kannan A, Das A, Demayo F, Hornsby P, Young S, et al. WNT4 acts downstream of BMP2 and functions via β-catenin signaling pathway to regulate human endometrial stromal cell differentiation. Endocrinology. 2013;154:446-57 pubmed publisher
Ludwig K, Tse E, Wang J. Colon cancer cells adopt an invasive phenotype without mesenchymal transition in 3-D but not 2-D culture upon combined stimulation with EGF and crypt growth factors. BMC Cancer. 2013;13:221 pubmed publisher
Tiwari A, Schneider M, Fiorino A, Haider R, Okoniewski M, Roschitzki B, et al. Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors. PLoS ONE. 2013;8:e69473 pubmed publisher
Son Y, Pratheeshkumar P, Wang L, Wang X, Fan J, Kim D, et al. Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling. Toxicol Appl Pharmacol. 2013;271:239-48 pubmed publisher
Engert S, Burtscher I, Liao W, Dulev S, Schotta G, Lickert H. Wnt/β-catenin signalling regulates Sox17 expression and is essential for organizer and endoderm formation in the mouse. Development. 2013;140:3128-38 pubmed publisher
Shao L, Oshima S, Duong B, Advincula R, Barrera J, Malynn B, et al. A20 restricts wnt signaling in intestinal epithelial cells and suppresses colon carcinogenesis. PLoS ONE. 2013;8:e62223 pubmed publisher
Tang Z, Dong Q, Cui Q, Papavassiliou P, Wang E, Wang E. Ataxia-telangiectasia group D complementing gene (ATDC) promotes lung cancer cell proliferation by activating NF-κB pathway. PLoS ONE. 2013;8:e63676 pubmed publisher
Bilir B, Kucuk O, Moreno C. Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells. J Transl Med. 2013;11:280 pubmed publisher
Miyazaki T, Miyazaki S, Ashida M, Tanaka T, Tashiro F, Miyazaki J. Functional analysis of Tcl1 using Tcl1-deficient mouse embryonic stem cells. PLoS ONE. 2013;8:e71645 pubmed publisher
Ghazvini M, Sonneveld P, Kremer A, Franken P, Sacchetti A, Atlasi Y, et al. Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis. PLoS ONE. 2013;8:e73872 pubmed publisher
Fong J, Jacobs R, Moravec D, Uppada S, Botting G, Nlend M, et al. Alternative signaling pathways as potential therapeutic targets for overcoming EGFR and c-Met inhibitor resistance in non-small cell lung cancer. PLoS ONE. 2013;8:e78398 pubmed publisher
Chen J, Chan A, To K, Chen W, Zhang Z, Ren J, et al. SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase-3β/β-catenin signaling. Hepatology. 2013;57:2287-98 pubmed publisher
Wang Y, Huang C, Reddy Chintagari N, Bhaskaran M, Weng T, Guo Y, et al. miR-375 regulates rat alveolar epithelial cell trans-differentiation by inhibiting Wnt/β-catenin pathway. Nucleic Acids Res. 2013;41:3833-44 pubmed publisher
Tran T, Shi X, Zaia J, Ai X. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration. J Biol Chem. 2012;287:32651-64 pubmed
Luan L, Ding T, Stinnett A, Reese J, Paria B. Adherens junction proteins in the hamster uterus: their contributions to the success of implantation. Biol Reprod. 2011;85:996-1004 pubmed publisher
Latasa M, Salis F, Urtasun R, Garcia-Irigoyen O, Elizalde M, Uriarte I, et al. Regulation of amphiregulin gene expression by β-catenin signaling in human hepatocellular carcinoma cells: a novel crosstalk between FGF19 and the EGFR system. PLoS ONE. 2012;7:e52711 pubmed publisher
Warr N, Siggers P, Bogani D, Brixey R, Pastorelli L, Yates L, et al. Sfrp1 and Sfrp2 are required for normal male sexual development in mice. Dev Biol. 2009;326:273-84 pubmed publisher
Wei W, Sun H, Ting K, Zhang L, Lee H, Li G, et al. Inhibition of cardiomyocytes differentiation of mouse embryonic stem cells by CD38/cADPR/Ca2+ signaling pathway. J Biol Chem. 2012;287:35599-611 pubmed publisher
Liu J, Wang Z, Tang J, Tang R, Shan X, Zhang W, et al. Hepatitis C virus core protein activates Wnt/β-catenin signaling through multiple regulation of upstream molecules in the SMMC-7721 cell line. Arch Virol. 2011;156:1013-23 pubmed publisher
Ceballos M, Parody J, Alvarez M, Ingaramo P, Carnovale C, Carrillo M. Interferon-α2b and transforming growth factor-β1 treatments on HCC cell lines: Are Wnt/β-catenin pathway and Smads signaling connected in hepatocellular carcinoma?. Biochem Pharmacol. 2011;82:1682-91 pubmed publisher
Son Y, Wang L, Poyil P, Budhraja A, Hitron J, Zhang Z, et al. Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling. Toxicol Appl Pharmacol. 2012;264:153-60 pubmed publisher
Blanchart A, Martín-López E, de Carlos J, Lopez-Mascaraque L. Peripheral contributions to olfactory bulb cell populations (migrations towards the olfactory bulb). Glia. 2011;59:278-92 pubmed publisher
Lussier C, Brial F, Roy S, Langlois M, Verdu E, Rivard N, et al. Loss of hepatocyte-nuclear-factor-1alpha impacts on adult mouse intestinal epithelial cell growth and cell lineages differentiation. PLoS ONE. 2010;5:e12378 pubmed publisher
Kato H, Gruenwald A, Suh J, Miner J, Barisoni-Thomas L, Taketo M, et al. Wnt/β-catenin pathway in podocytes integrates cell adhesion, differentiation, and survival. J Biol Chem. 2011;286:26003-15 pubmed publisher
Wang D, Dai C, Li Y, Liu Y. Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria. Kidney Int. 2011;80:1159-69 pubmed publisher
Lambertini E, Lisignoli G, Torreggiani E, Manferdini C, Gabusi E, Franceschetti T, et al. Slug gene expression supports human osteoblast maturation. Cell Mol Life Sci. 2009;66:3641-53 pubmed publisher
Bosco E, Nakai Y, Hennigan R, Ratner N, Zheng Y. NF2-deficient cells depend on the Rac1-canonical Wnt signaling pathway to promote the loss of contact inhibition of proliferation. Oncogene. 2010;29:2540-9 pubmed publisher
Kodithuwakku S, Pang R, Ng E, Cheung A, Horne A, Ho P, et al. Wnt activation downregulates olfactomedin-1 in Fallopian tubal epithelial cells: a microenvironment predisposed to tubal ectopic pregnancy. Lab Invest. 2012;92:256-64 pubmed publisher
Pourreyron C, Reilly L, Proby C, Panteleyev A, Fleming C, McLean K, et al. Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed. PLoS ONE. 2012;7:e31827 pubmed publisher
Jacob F, Ukegjini K, Nixdorf S, Ford C, Olivier J, Caduff R, et al. Loss of secreted frizzled-related protein 4 correlates with an aggressive phenotype and predicts poor outcome in ovarian cancer patients. PLoS ONE. 2012;7:e31885 pubmed publisher
Winslow B, Burke A. Atypical molecular profile for joint development in the avian costal joint. Dev Dyn. 2010;239:2547-57 pubmed publisher
Kohan-Ghadr H, Smith L, Arnold D, Murphy B, Lefebvre R. Aberrant expression of E-cadherin and β-catenin proteins in placenta of bovine embryos derived from somatic cell nuclear transfer. Reprod Fertil Dev. 2012;24:588-98 pubmed publisher
Clinkenbeard E, Butler J, Spear B. Pericentral activity of alpha-fetoprotein enhancer 3 and glutamine synthetase upstream enhancer in the adult liver are regulated by β-catenin in mice. Hepatology. 2012;56:1892-901 pubmed publisher
Welters H, Oknianska A, Erdmann K, Ryffel G, Morgan N. The protein tyrosine phosphatase-BL, modulates pancreatic beta-cell proliferation by interaction with the Wnt signalling pathway. J Endocrinol. 2008;197:543-52 pubmed publisher
Law P, Ching A, Chan A, Wong Q, Wong C, To K, et al. MiR-145 modulates multiple components of the insulin-like growth factor pathway in hepatocellular carcinoma. Carcinogenesis. 2012;33:1134-41 pubmed publisher
Yoshioka S, King M, Ran S, Okuda H, Maclean J, McAsey M, et al. WNT7A regulates tumor growth and progression in ovarian cancer through the WNT/β-catenin pathway. Mol Cancer Res. 2012;10:469-82 pubmed publisher
Jia L, Miao C, Cao Y, Duan E. Effects of Wnt proteins on cell proliferation and apoptosis in HEK293 cells. Cell Biol Int. 2008;32:807-13 pubmed publisher
Vinuesa A, Sancho R, García-Limones C, Behrens A, Ten Dijke P, Calzado M, et al. Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer. Cancer Res. 2012;72:1705-16 pubmed publisher
Liu L, Alonso V, Guo L, Tourkova I, Henderson S, Almarza A, et al. Na+/H+ exchanger regulatory factor 1 (NHERF1) directly regulates osteogenesis. J Biol Chem. 2012;287:43312-21 pubmed publisher
Mödder U, Oursler M, Khosla S, Monroe D. Wnt10b activates the Wnt, notch, and NFκB pathways in U2OS osteosarcoma cells. J Cell Biochem. 2011;112:1392-402 pubmed publisher
Behr B, Longaker M, Quarto N. Differential activation of canonical Wnt signaling determines cranial sutures fate: a novel mechanism for sagittal suture craniosynostosis. Dev Biol. 2010;344:922-40 pubmed publisher
Ng F, Toh T, Ting E, Koh G, Sandanaraj E, Phong M, et al. Progenitor-like traits contribute to patient survival and prognosis in oligodendroglial tumors. Clin Cancer Res. 2012;18:4122-35 pubmed
Ray S, Xu F, Wang H, Das S. Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. Mol Endocrinol. 2008;22:1125-40 pubmed publisher
Griffin C, Curtis C, Davis R, Muthukumar V, Magnuson T. The chromatin-remodeling enzyme BRG1 modulates vascular Wnt signaling at two levels. Proc Natl Acad Sci U S A. 2011;108:2282-7 pubmed publisher
product information
Catalog Number :
05-665
Subcategory :
Epigenetics & Nuclear Function
Product Name :
Anti-Active-β-Catenin (Anti-ABC) Antibody, clone 8E7
Product Type :
Antibodies
Clonality :
Monoclonal Antibody
Gene ID :
P35222
Host Name :
Mouse
Antigen :
Active-β-Catenin (ABC)
Clone :
8E7
Conjugate :
Purified
Isotype :
IgG1κ
Product Description :
Anti-Active-β-Catenin (Anti-ABC) Antibody, clone 8E7
Cross Reactivity :
Human;Mouse;Rat
Background :
Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. When β-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in β-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When β-catenin is not associated with cadherins and α-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that β-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy. HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.
Immunogen :
Fusion protein corresponding to residues 1-100 of human β-catenin with a c-terminal histidine tag
Specificity :
Recognizes active form of β-catenin, dephosphorylated on Ser37 or Thr41.
Package Size :
100 μg
Uses :
Flow Cytometry;Immunocytochemistry;Immunohistochemistry;Immunohistochemistry (Paraffin);Western Blotting
Storage :
Maintain for 1 year at 2-8°C from date of shipment. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
more info or order :
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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