product summary
request information :
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO
product type :
product name :
Anti-Active-beta-Catenin (anti-ABC), clone 8E7
catalog :
quantity :
100 ug
price :
clonality :
host :
reactivity :
zebrafish , human
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry
publications citing this reagent :
  1. WB
    Ray S, Xu F, Wang H, Das S. Cooperative control via lymphoid enhancer factor 1/T cell factor 3 and estrogen receptor-alpha for uterine gene regulation by estrogen. Mol Endocrinol. 2008;22:1125-40 PMID 18202148 CrossRef
more info or order :
product information
Catalog Number :
Category :
Subcategory :
Epigenetics & Nuclear Function
Product Name :
Anti-Active-beta-Catenin (anti-ABC), clone 8E7
Product Type :
Clonality :
Gene ID :
Host Name :
Clone :
Conjugate :
Isotype :
Product Description :
Anti-Active-beta-Catenin (anti-ABC), clone 8E7
Cross Reactivity :
Human, Mouse, Rat
Species Summary :
The antibody eptiope is 100% conserved in zebrafish.
Background :
Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as alpha-catenin and beta-catenin. alpha-catenin can bind to beta-catenin and can also bind actin. beta-catenin binds the cytoplasmic domain of some cadherins. When beta-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in beta-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When beta-catenin is not associated with cadherins and alpha-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC).
Immunogen :
Fusion protein corresponding to residues 1-100 of human beta-catenin with a c-terminal histidine tag
Specificity :
Recognizes active form of beta-catenin, dephosphorylated on Ser37 or Thr41.
Purity :
Protein G purfied
Package Size :
100 ug
Uses :
Storage :
Maintain for 1 year at 2-8°C from date of shipment.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.
more info or order :
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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