phospho-Ribosomal Protein S6 (Ser235) Antibody, clone MC27, rabbit monoclonal

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

phospho-Ribosomal Protein S6 (Ser235) Antibody, clone MC27, rabbit monoclonal

catalog :

04-795

quantity :

100 µL

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

MC27

reactivity :

human, mouse

application :

western blot

product information

Catalog Number :

04-795

Subcategory :

Cell Signaling

Product Name :

Anti-phospho-Ribosomal Protein S6 (Ser235) Antibody, clone MC27, rabbit monoclonal

Product Type :

Antibodies

Clonality :

Monoclonal Antibody

Gene ID :

P62753

Host Name :

Rabbit

Antigen :

phospho-Ribosomal Protein S6 (Ser235)

Clone :

MC27

Conjugate :

Culture Supernatant

Isotype :

IgG

Product Description :

Anti-phospho-Ribosomal Protein S6 (Ser235) Antibody, clone MC27, rabbit monoclonal

Cross Reactivity :

Human;Mouse;Rat

Background :

S6 (Ribosomal protein S6, RpS6, 40S ribosomal protein S6) is known to play a role in cell growth and proliferation. It lays downstream of both the PI3K/Akt/mTOR pathway as a substrate of p70 S6 kinase and the Ras/Erk pathway as a substrate of RSK. S6 is phosphorylated in response to stimulation by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. There are two major areas of S6 phosphorylation; Ser235/Ser236 that is known to be phosphorylated by both p70S6 Kinase as well as RSK as well as Ser240/244 which is thought to only be phosphorylated by p70S6K.

ALT Names :

40S ribosomal protein S6;Phosphoprotein NP33 ;ribosomal protein S6

Immunogen :

Synthetic peptide containing the sequence …RRL[pS]SL… in which pS corresponds to phospho-serine at residue 235 of human ribosomal protein S6. The immunizing sequence is identical in mouse, rat, chicken and Xenopus.

Specificity :

Recognizes ribosomal protein S6 only when phosphorylated on Ser235.

Package Size :

100 µL

Uses :

Western Blotting

Storage :

Stable for 1 year at -20ºC from date of receipt. Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.