This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Addgene
product type :
cDNA
product name :
pDEST53-LRRK2-WT
catalog :
25044
citations: 7
Reference
Snead D, Matyszewski M, Dickey A, Lin Y, Leschziner A, Reck Peterson S. Structural basis for Parkinson's disease-linked LRRK2's binding to microtubules. Nat Struct Mol Biol. 2022;29:1196-1207 pubmed publisher
Fdez E, Madero Pérez J, Lara Ordóñez A, Naaldijk Y, Fasiczka R, Aiastui A, et al. Pathogenic LRRK2 regulates centrosome cohesion via Rab10/RILPL1-mediated CDK5RAP2 displacement. iScience. 2022;25:104476 pubmed publisher
Lin Y, Lin C, Ho E, Ke Y, Petridi S, Elliott C, et al. Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson's disease. elife. 2021;10: pubmed publisher
Oliveira S, Dionísio P, Gaspar M, Correia Guedes L, Coelho M, Rosa M, et al. miR-335 Targets LRRK2 and Mitigates Inflammation in Parkinson's Disease. Front Cell Dev Biol. 2021;9:661461 pubmed publisher
Myasnikov A, Zhu H, Hixson P, Xie B, Yu K, Pitre A, et al. Structural analysis of the full-length human LRRK2. Cell. 2021;184:3519-3527.e10 pubmed publisher
Neethling A, Engelbrecht L, Loos B, Kinnear C, Theart R, Abrahams S, et al. Wild-type and mutant (G2019S) leucine-rich repeat kinase 2 (LRRK2) associate with subunits of the translocase of outer mitochondrial membrane (TOM) complex. Exp Cell Res. 2019;375:72-79 pubmed publisher
Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, et al. Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiol Dis. 2006;23:329-41 pubmed
product information
Catalog Number :
25044
Product Name :
pDEST53-LRRK2-WT
article :
doi10.1016/j.nbd.2006.04.001
id3418
pubmed_id16750377
bacterial resistance :
Ampicillin
cloning :
backbonepcDNA-DEST53
backbone_mutation
backbone_originInvitrogen
backbone_size7767
promoter
sequencing_primer_3
sequencing_primer_5
vector_types
Mammalian Expression
origin :
37
pi :
alt_names
cloning
clone_methodGateway Cloning
cloning_site_3attR2
cloning_site_5attR1
promoter
sequencing_primer_3BGH-rev
sequencing_primer_5CMV-F, GFP-F
site_3_destroyed
site_5_destroyed
entrez_gene
aliasesAURA17, DARDARIN, PARK8, RIPK7, ROCO2
geneLRRK2
id120892
genbank_ids
mutation
nameLRRK2
shRNA_sequence
size7584
species
9606
Homo sapiens
tags
locationN terminal on insert
tagGFP
resistance markers :
89
tags :
High Copy
company information
Addgene
490 Arsenal Way, Suite 100
Watertown, MA 02472
info@addgene.org
https://www.addgene.org
617.225.9000
headquarters: USA