This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-PPAR alpha antibody
catalog :
ab8934
quantity :
100 µg
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
hamsters, human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 35
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:10,000; loading ...; fig 5E
Kodo K, Sugimoto S, Nakajima H, Mori J, Itoh I, Fukuhara S, et al. Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice. PLoS ONE. 2017;12:e0173661 pubmed publisher
  • western blot; mouse; loading ...; fig 5f
Liu Z, Gan L, Wu T, Feng F, Luo D, Gu H, et al. Adiponectin reduces ER stress-induced apoptosis through PPARα transcriptional regulation of ATF2 in mouse adipose. Cell Death Dis. 2016;7:e2487 pubmed publisher
  • western blot; human; 1:400; fig st1
Treindl F, Ruprecht B, Beiter Y, Schultz S, Döttinger A, Staebler A, et al. A bead-based western for high-throughput cellular signal transduction analyses. Nat Commun. 2016;7:12852 pubmed publisher
  • immunocytochemistry; human; 1:50; fig 2
Cizkova K, Steigerova J, Gursky J, Ehrmann J. Stimulating effect of normal-dosing of fibrates on cell proliferation: word of warning. Lipids Health Dis. 2016;15:164 pubmed
  • western blot; hamsters
Samms R, Murphy M, Fowler M, Cooper S, Emmerson P, Coskun T, et al. Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. J Endocrinol. 2015;227:37-47 pubmed publisher
  • western blot; mouse; fig 6b
Petrov D, Pedrós I, Artiach G, Sureda F, Barroso E, Pallas M, et al. High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. Biochim Biophys Acta. 2015;1852:1687-99 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3B
  • western blot; rat; 1:1000; loading ...; fig 3B
Zhang X, Zhang J, Chen X, Hu Q, Wang M, Jin R, et al. Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. Antioxid Redox Signal. 2015;22:848-70 pubmed publisher
  • western blot; human; 1:500
  • western blot; rat; 1:500
Wang W, Wang C, Ding X, Pan Y, Gu T, Wang M, et al. Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. Br J Pharmacol. 2013;169:1352-71 pubmed publisher
Lin C, Wu J, Jian J, Shih C. (-)-Epicatechin-3-O-?-D-allopyranoside from Davallia formosana prevents diabetes and dyslipidemia in streptozotocin-induced diabetic mice. PLoS ONE. 2017;12:e0173984 pubmed publisher
De Jong A, Carreira S, Na N, Carillion A, Jiang C, Beuvin M, et al. Diaphragmatic function is enhanced in fatty and diabetic fatty rats. PLoS ONE. 2017;12:e0174043 pubmed publisher
Hajarnis S, Lakhia R, Yheskel M, Williams D, Sorourian M, Liu X, et al. microRNA-17 family promotes polycystic kidney disease progression through modulation of mitochondrial metabolism. Nat Commun. 2017;8:14395 pubmed publisher
Li X, Deng Y, Li F, Shi J, Gong Q. Neuroprotective effects of sodium hydrosulfide against ?-amyloid-induced neurotoxicity. Int J Mol Med. 2016;38:1152-60 pubmed publisher
Zhang L, Ren F, Zhang X, Wang X, Shi H, Zhou L, et al. Peroxisome proliferator-activated receptor alpha acts as a mediator of endoplasmic reticulum stress-induced hepatocyte apoptosis in acute liver failure. Dis Model Mech. 2016;9:799-809 pubmed publisher
Kuo Y, Lin C, Shih C. Dehydroeburicoic Acid from Antrodia camphorata Prevents the Diabetic and Dyslipidemic State via Modulation of Glucose Transporter 4, Peroxisome Proliferator-Activated Receptor ? Expression and AMP-Activated Protein Kinase Phosphorylation in High-Fat-. Int J Mol Sci. 2016;17: pubmed publisher
Kuo Y, Lin C, Shih C, Yang C. Antcin K, a Triterpenoid Compound from Antrodia camphorata, Displays Antidiabetic and Antihyperlipidemic Effects via Glucose Transporter 4 and AMP-Activated Protein Kinase Phosphorylation in Muscles. Evid Based Complement Alternat Med. 2016;2016:4867092 pubmed publisher
Zhao Y, Chen K, Shen X. Environmental Enrichment Attenuated Sevoflurane-Induced Neurotoxicity through the PPAR-γ Signaling Pathway. Biomed Res Int. 2015;2015:107149 pubmed publisher
Cui X, Luan J, Ye J, Chen S. RGC32 deficiency protects against high-fat diet-induced obesity and insulin resistance in mice. J Endocrinol. 2015;224:127-37 pubmed publisher
Ren T, Huang C, Cheng M. Dietary blueberry and bifidobacteria attenuate nonalcoholic fatty liver disease in rats by affecting SIRT1-mediated signaling pathway. Oxid Med Cell Longev. 2014;2014:469059 pubmed publisher
Singh A, Joharapurkar A, Khan M, Mishra J, Singh N, Yadav M, et al. Orally active osteoanabolic agent GTDF binds to adiponectin receptors, with a preference for AdipoR1, induces adiponectin-associated signaling, and improves metabolic health in a rodent model of diabetes. Diabetes. 2014;63:3530-44 pubmed publisher
Gori M, Barbaro B, Arciello M, Maggio R, Viscomi C, Longo A, et al. Protective effect of the Y220C mutant p53 against steatosis: good news?. J Cell Physiol. 2014;229:1182-92 pubmed publisher
Gurha P, Wang T, Larimore A, Sassi Y, Abreu Goodger C, Ramirez M, et al. microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PLoS ONE. 2013;8:e75882 pubmed publisher
Shi L, Shi L, Zhang H, Hu Z, Wang C, Zhang D, et al. Oxymatrine ameliorates non-alcoholic fatty liver disease in rats through peroxisome proliferator-activated receptor-? activation. Mol Med Rep. 2013;8:439-45 pubmed publisher
Nakles R, Kallakury B, Furth P. The PPAR? agonist efatutazone increases the spectrum of well-differentiated mammary cancer subtypes initiated by loss of full-length BRCA1 in association with TP53 haploinsufficiency. Am J Pathol. 2013;182:1976-85 pubmed publisher
Botelho P, Mariano K, Rogero M, de Castro I. Effect of Echium oil compared with marine oils on lipid profile and inhibition of hepatic steatosis in LDLr knockout mice. Lipids Health Dis. 2013;12:38 pubmed publisher
Ito M, Yamanashi Y, Toyoda Y, Izumi Nakaseko H, Oda S, Sugiyama A, et al. Disruption of Stard10 gene alters the PPAR?-mediated bile acid homeostasis. Biochim Biophys Acta. 2013;1831:459-68 pubmed publisher
Dong K, Zhang M, Liu Y, Su X, Chen B, Zhang X. Peroxisome proliferator-activated receptor alpha expression changes in human pregnant myometrium. Reprod Sci. 2013;20:654-60 pubmed publisher
Yamada T, Ivarsson N, Hernandez A, Fahlström A, Cheng A, Zhang S, et al. Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice. J Physiol. 2012;590:6187-97 pubmed publisher
Knapp P, Chabowski A, Błachnio Zabielska A, Jarzabek K, Wołczyński S. Altered peroxisome-proliferator activated receptors expression in human endometrial cancer. PPAR Res. 2012;2012:471524 pubmed publisher
Zhao Y, Tan Y, Strynar M, Perez G, Haslam S, Yang C. Perfluorooctanoic acid effects on ovaries mediate its inhibition of peripubertal mammary gland development in Balb/c and C57Bl/6 mice. Reprod Toxicol. 2012;33:563-76 pubmed publisher
Nishimura K, Yamauchi N, Chowdhury V, Torii M, Hattori M, Kaneto M. Expression of peroxisome proliferator-activated receptor isoforms in the rat uterus during early pregnancy. Cell Tissue Res. 2011;345:275-84 pubmed publisher
Ismail I, Andrin C, McDonald D, Hendzel M. BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair. J Cell Biol. 2010;191:45-60 pubmed publisher
Jansen S, Cashman K, Thompson J, Pantaleon M, Kaye P. Glucose deprivation, oxidative stress and peroxisome proliferator-activated receptor-alpha (PPARA) cause peroxisome proliferation in preimplantation mouse embryos. Reproduction. 2009;138:493-505 pubmed publisher
Peng Z, Borea P, Varani K, Wilder T, Yee H, Chiriboga L, et al. Adenosine signaling contributes to ethanol-induced fatty liver in mice. J Clin Invest. 2009;119:582-94 pubmed publisher
Nicolete R, Rius C, Piqueras L, Jose P, Sorgi C, Soares E, et al. Leukotriene B4-loaded microspheres: a new therapeutic strategy to modulate cell activation. BMC Immunol. 2008;9:36 pubmed publisher
Beraza N, Malato Y, Vander Borght S, Liedtke C, Wasmuth H, Dreano M, et al. Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis. Gut. 2008;57:655-63 pubmed publisher
product information
CatalogNumber :
ab8934
ItemName :
Anti-PPAR alpha antibody
Product Type :
Antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugate :
Unconjugated
Size :
100 µg
SpeciesSummary :
Hu, Ms, Rat
Purity :
Immunogen affinity purified
Application Summary :
ELISA, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, WB
company information
Abcam
330 Cambridge Science Park
Cambridge
CB4 0FL UK
orders@abcam.com
44 (0)1223 696000

1 Kendall Square, Ste 341
Cambridge, MA 02139-1517
USA
us.orders@abcam.com
617 225 2272, 888-77-ABCAM (22226)

www.abcam.com
888-7722226
headquarters: UK