product summary
request information :
company name :
Abbiotec
product type :
antibody
product name :
ER-alpha (C-term) Antibody
catalog :
250637
quantity :
0.1 mg
price :
251 USD
clonality :
polyclonal
host :
rabbit
reactivity :
human, rat, mouse
application :
western blot, ELISA, immunoprecipitation, immunohistochemistry
more info or order :
product information
Product Name :
ER-alpha (C-term) Antibody
Product Subcategory :
Rabbit Polyclonal Antibody
Catalog No :
250637
Unit :
0.1 mg
Price :
251 USD
Product Category :
Antibodies
Protein Family :
Receptors and Channels, Transcription Factors
Pathway and Disease :
Cancers, Signaling Molecules and Interaction, Transcription
Description :
Estrogen and progesterone receptors are members of a family transcription factors regulated by the binding of their cognate ligands. The interaction of hormone bound estrogen receptors with estrogen responsive elements (EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrogen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER alpha and ER beta. Both have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B) which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A functions as a transcriptional inhibitor of all steroid hormone receptors.
Format :
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.
Applications :
E, WB, IHC, IP
Alternate Names :
Estrogen receptor; ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1; ESR1; ESR; NR3A1
Accession No :
P03372
Isotype :
Rabbit Ig
Antigen :
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human ER-alpha.
Species Reactivity :
H, M, R
Application Notes :
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:200-1:500
Storage :
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
more info or order :
company information
Abbiotec
7985 Dunbrook Road, Suite A
San Diego, CA 92126
info@abbiotec.com
www.abbiotec.com
1-858-586-0500
headquarters: usa
As researchers are focusing their efforts on determining the biological functions, interactions and regulation of the human proteome, Abbiotec is dedicated to developing cell biology-based research tools that assist scientific discoveries.