VEGF-R3/FLT-4 ELISA | ALPCO 61-FLTHU-E01 product information

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product summary

company name :

ALPCO

product type :

ELISA/assay

product name :

VEGF-R3/FLT-4 ELISA

catalog :

61-FLTHU-E01

quantity :

96 Wells

price :

700.00 USD

product information

Catalog Number :

61-FLTHU-E01

Product Name :

VEGF-R3/FLT-4 ELISA

List Price :

700.00 USD

Description :

The main function of the lymphatic system is to return plasma back to the circulating blood. Plasma fluid, macromolecules and cells, such as leucocytes and activated antigen-presenting cells, enter the blind-ended lymphatic vessels. Lymph is then transported toward collecting lymphatic vessels and is returned to the blood circulation. Scientific studies over the past years have revealed a signal-transduction system for lymphatic endothelial cell growth, migration and survival. This system is formed by VEGF-C and VEGF-D and their shared receptor VEGFR-3/FLT-4. Homozygous deletion of VEGFR-3 in mice leads to defects in blood-vessel remodelling and embryonic death at mid-gestation, indicating an early vascular function for the receptor. Furthermore mouse studies suggest that upregulation and activation of VEGFR-3 have functional roles in sprouting angiogenesis and that VEGFR-3 is an important effector of the vascular phenotype resulting from Notch inhibition. In lymphoma patients, high expression of VEGFR-3 can been found in lymph endothelial cells isolated from the tumour tissue.

Therapeutic Areas :

Immunology

Species :

Human

Sample Types :

Cell Culture, Citrate Plasma, Serum

Size :

96 Wells

Regulatory Status :

Research Use Only. Not for Use in Diagnostic Procedures.

Product Distribution :

Available Worldwide

Applications :

Immunoassays

Sample Size :

50 µL

Range :

0.6 - 40.0 ng/mL

Sensitivity :

0.03 ng/mL

Incubation Time :

3hr 30min